Recombinant Human Fc epsilon RI alpha Protein

COA

级别和纯度:

≥95%(SDS-PAGE)

表达系统: HEK293
Accession #: P12319
蛋白标签: C-His
生物活性: Immobilized FITC anti-human FcεRIα Antibody at 1μg/mL (25 μL/well) can bind Human Fc epsilon RI alpha with a linear range of 0.46-3.15 ng/mL.
内毒素水平: <0.1 EU/μg

有货

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货号 (SKU)	包装规格	是否现货
rp145872-10μg	10μg	现货
rp145872-50μg	50μg	现货
rp145872-100μg	100μg	现货
rp145872-1mg	1mg	期货

查看相关系列

点击查看蛋白信息: FCER1A

Accession#: P12319 (1) Fc epsilon RI (1) Fc epsilon RI alpha (1) FCER1A (1) Gene ID: 2205 (1)

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基本描述

产品名称	Recombinant Human Fc epsilon RI alpha Protein
别名	重组人Fc epsilon RI/FCER1A蛋白 \| 重组人 Fc epsilon RI alpha 蛋白
英文别名	Fc-epsilon RI-alpha \| FcERI \| IgE Fc receptor subunit alpha \| Fc epsilon RI alpha \| Fc epsilon RI alpha chain \| Fc epsilon RI alpha-chain \| Fc fragment of IgE high affinity I receptor for alpha polypeptide \| Fc fragment of IgE, high affinity I, receptor f
规格或纯度	ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
产品介绍	Purity ≥95% (SDS-PAGE) Endotoxin level ＜0.1 EU/μg Function Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
生物活性	Immobilized FITC anti-human FcεRIα Antibody at 1μg/mL (25 μL/well) can bind Human Fc epsilon RI alpha with a linear range of 0.46-3.15 ng/mL.
内毒素水平	<0.1 EU/μg
表达系统	HEK293
种属	人(Human)
氨基酸	26-205 aa
序列	VPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQHHHHHH
纯度	≥95% (SDS-PAGE)
蛋白标签	C-His
无载体	Yes
无动物源	Yes
Accession #	P12319
预测分子量	22 kDa
SDS-PAGE	38 - 50 kDa, under reducing conditions; 38 - 50 kDa, under non-reducing conditions.

储存与运输

物理形态	冻干(Lyophilized)
储存缓冲液	Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶	Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度	-20°C储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
分子类型	蛋白质

图片

SDS-PAGE: Recombinant Human Fc epsilon RI alpha Protein (rp145872)

Recombinant Human Fc epsilon RI alpha Protein (rp145872) - SDS-PAGE
3 μg/lane of Recombinant Human Fc epsilon RI alpha Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 38 - 50 kDa.

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找到3个结果

批号(Lot Number)	证书类型	货号
ZJ24F0607369	分析证书	rp145872
ZJ24F0607367	分析证书	rp145872
ZJ24F0607368	分析证书	rp145872

技术文档和文章

引用文献

1. Gounni AS, Lamkhioued B, Ochiai K, Tanaka Y, Delaporte E, Capron A, Kinet JP, Capron M. (1994) High-affinity IgE receptor on eosinophils is involved in defence against parasites.. Nature, 367 (6459): (183-6). [PMID:8114916]
2. Padlan, E A EA and Helm, B A BA.. (1992) A modeling study of the alpha-subunit of human high-affinity receptor for immunoglobulin-E.. Receptor, [PMID:1472946]
3. Shimizu, A A and 5 more authors.. (1988) Human and rat mast cell high-affinity immunoglobulin E receptors: characterization of putative alpha-chain gene products.. Proceedings of the National Academy of Sciences of the United States of America, [PMID:2964640]
4. Kochan, J J, Pettine, L F LF, Hakimi, J J, Kishi, K K and Kinet, J P JP.. (1988) Isolation of the gene coding for the alpha subunit of the human high affinity IgE receptor.. Nucleic acids research, (25): [PMID:2967464]
5. Yagi, S S and 5 more authors.. (1994) High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product.. European journal of biochemistry, (1): [PMID:8125119]
6. Garman, S C SC, Wurzburg, B A BA, Tarchevskaya, S S SS, Kinet, J P JP and Jardetzky, T S TS.. (2000) Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.. Nature, (20): [PMID:10917520]
7. Garman, S C SC, Sechi, S S, Kinet, J P JP and Jardetzky, T S TS.. (2001) The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms.. Journal of molecular biology, (31): [PMID:11531339]
8. Beck, Lisa A LA, Marcotte, Gregory V GV, MacGlashan, Donald D, Togias, Alkis A and Saini, Sarbjit S.. (2004) Omalizumab-induced reductions in mast cell Fce psilon RI expression and function.. The Journal of allergy and clinical immunology, [PMID:15356552]
9. Mirkina, Irina I, Schweighoffer, Tamás T and Kricek, Franz F.. (2007) Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab.. Immunology letters, (15): [PMID:17368811]
10. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352]

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