| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R654811-1ml |
1ml |
期货  |
|
| 别名 | Raf 抑制剂 1 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Raf inhibitor 1 |
| 生化机理 | Raf 抑制剂 1 是一种强效 Raf 激酶抑制剂，对 B-Raf WT、B-Raf V600E 和 C-Raf 的 K i s 分别为 1 nM、1 nM 和 0.3 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Raf inhibitor 1 is a potent Raf kinase inhibitor with K i s of 1 nM, 1 nM, and 0.3 nM for B-Raf WT , B-Raf V600E , and C-Raf , respectively. In Vitro Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:B-Raf 1 nM (Ki) B-Raf V600E 1 nM (Ki) c-Raf 0.3 nM (Ki) |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6 |
| PubChem CID | 44223999 |
| 分子量 | 478.9 |
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