| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R609492-5mg |
5mg |
期货  |
| |
| R609492-25mg |
25mg |
期货 |
|
| 别名 | 精氨酸酶抑制剂1 |
|---|---|
| 英文别名 | arginase inhibitor 1 | compound 9 |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Arginase inhibitor 1 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 精氨酸酶 I 抑制剂；精氨酸酶 II 抑制剂 |
| 产品介绍 |
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (2R)-2-amino-6-borono-2-(2-piperidin-1-ylethyl)hexanoic acid |
| INCHI | 1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m1/s1 |
| InChi Key | CHPILBYRQPOXMV-CYBMUJFWSA-N |
| Smiles | OB(CCCC[C@](C(=O)O)(CCN1CCCCC1)N)O |
| Isomeric SMILES | B(CCCC[C@@](CCN1CCCCC1)(C(=O)O)N)(O)O |
| PubChem CID | 66833213 |
| 分子量 | 286.18 |
| 分子量 | 286.180 g/mol |
|---|---|
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 6 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 286.206 Da |
| 单同位素质量Monoisotopic Mass | 286.206 Da |
| 拓扑极表面积Topological Polar Surface Area | 107.000 Ų |
| 重原子数Heavy Atom Count | 20 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 298.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
¥610.90
¥479.90
¥1,800.90
| 1. Van Zandt MC, Whitehouse DL, Golebiowski A, Ji MK, Zhang M, Beckett RP, Jagdmann GE, Ryder TR, Sheeler R, Andreoli M et al.. (2013) Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.. J Med Chem, 56 (6): (2568-80). [PMID:23472952] |
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