| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R422467-1ml |
1ml |
现货  |
|
| 英文别名 | rosmarinic acid | 20283-92-5 | Rosemary acid | Labiatenic acid | Rosmarinicacid | Labiatic acid | (R)-rosmarinic acid | trans-Rosmarinic acid | Rosemaric acid | Rosmarinic acid racemate | Rosmarinate | Rosmarinic-acid | UNII-MQE6XG29YI | MQE6XG29YI | CCRIS 9361 | RM 21A | 537-15-5 | ORIST |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Rosmarinic acid |
| 生化机理 | 迷迭香酸是从唇形科草本植物中分离出来的一种苯丙氨酸。该化合物具有抗炎活性，并能抑制小鼠间质细胞的增殖。研究表明，迷迭香酸对 Ls174-T 人类结肠癌细胞的迁移、粘附和侵袭具有剂量依赖性抑制作用。在同一项研究中，迷迭香酸诱导了 CRE 结合蛋白（CREB）的磷酸化，并激活了 cAMP 反应元件（CRE）。在经典补体途径中，迷迭香酸可抑制 C3 转化酶。它还是 GPR35 的激活剂。具有抗氧化、抗炎和抗微生物活性。还能抑制细胞凋亡。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
An activator of GPR35. An activator of GPR35. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid |
| INCHI | 1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1 |
| InChi Key | DOUMFZQKYFQNTF-WUTVXBCWSA-N |
| Smiles | OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2 |
| Isomeric SMILES | C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O |
| PubChem CID | 5281792 |
| 分子量 | 360.31 |
| Beilstein号 | 2227587 |
| 熔点 | 171-175°C |
|---|---|
| 分子量 | 360.300 g/mol |
| XLogP3 | 2.400 |
| 氢键供体数Hydrogen Bond Donor Count | 5 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 7 |
| 精确质量Exact Mass | 360.085 Da |
| 单同位素质量Monoisotopic Mass | 360.085 Da |
| 拓扑极表面积Topological Polar Surface Area | 145.000 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 519.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06, GHS09 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 H400: 对水生生物有剧毒 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P273: 避免释放到环境中。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P391: 收集溢出物 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 |
| WGK Germany | 3 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
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