乙氧基试卤灵

荧光微粒体脱烷基酶和CYP450底物

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COA

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≥95%(UV)

CAS编号: 5725-91-7
分子式: C₁₄H₁₁NO₃
分子量: 241.24
Beilstein号: 225973
MDL号: MFCD00037661
PubChem编号: 3294

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货号 (SKU)	包装规格	是否现货
R131523-1mg	1mg	期货
R131523-5mg	5mg	现货
R131523-25mg	25mg	期货

查看相关系列

Cytochrome P450 (243) Immunology/Inflammation (1938) Metabolic Enzyme/Protease (4889) NO Synthase (134) 脂质代谢 (4331)

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基本描述

别名	7-乙氧基resorufin
英文别名	7-ER \| 7-Ethoxy-3H-phenoxazin-3-one \| SCHEMBL104497 \| FT-0668125 \| UNII-59AF853SW7 \| BDBM21360 \| J-100239 \| 59AF853SW7 \| HY-D0145 \| AS-59402 \| CHEBI:34480 \| RESORUFINETHYLETHER \| Q27116097 \| Resorufinethyl ether \| 7-Ethoxyresorufin \| 3H-Phenoxazin-3-one,
规格或纯度	≥95%(UV)
英文名称	Resorufin ethyl ether
生化机理	荧光微粒体脱烷基酶和CYP450底物。产生红色荧光染料试卤灵（Ex / Em 571/585 nm）。适用于xA0区分CYP同工酶1A1和1A2。
应用	7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.
储存温度	-20°C储存
运输条件	超低温冰袋运输
备注	有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thoμght to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1.7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals. 7-Ethoxyresorufin is a fluorimetric substrate and suicide inhibitor of CYP (cytochrome P450). Also shown to inhibit several reductase enzymes, specifically CYPOR (NADPH-P450 reductase). The binding to CYP (cytochrome P450) is thought to inhibit the vasorelaxant response to acetylcholine. 7-Ethoxyresorufin has also demonstrated inhibition of NO synthesis by uncoupling neuronal NOS1 (nitric oxide synthase); it is a noncompetitive inhibitor of neuronal NOS1 with respect to L-arginine with a Ki value of 0.76 +/- 0.06 μM. 7-Ethoxyresorufin is a substate of CYP1A1. 7-Ethoxyresorufin (7-ER) is a substrate used in environmental toxicology studies to monitor ethoxyresorufin-O-deethylase catalytic activity in the EROD assay. The EROD assay monitors the induction of the xenobiotic-metabolizing enzyme cytochrome P-450 (CYP) 1A1 and is a widely used biomarker for exposure of wildlife to substances that bind the aryl hydrocarbon (Ah) receptor. It provides evidence of receptor-mediated induction of cytochrome P450-dependant monooxygenases (the CYP1A subfamily specifically) by xenobiotic chemicals.
纯度	≥95%(UV)

关联靶点（人）

CYP1A2 Tchem 细胞色素 P450 1A2(Cytochrome P450 1A2) (2 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

APP Tclin 淀粉样β蛋白A4(Amyloid-beta A4 protein) (1 活性数据)

点击查看靶蛋白信息： APP

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

APP Tclin Amyloid-beta A4 protein (8510 活性数据)

点击查看靶蛋白信息： APP

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)

点击查看靶蛋白信息： CYP1A2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	7-ethoxyphenoxazin-3-one
INCHI	1S/C14H11NO3/c1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h3-8H,2H2,1H3
InChi Key	CRCWUBLTFGOMDD-UHFFFAOYSA-N
Smiles	CCOC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2
Isomeric SMILES	CCOC1=CC2=C(C=C1)N=C3C=CC(=O)C=C3O2
PubChem CID	3294
分子量	241.24
Beilstein号	225973

化学和物理性质

溶解性	Soluble in DMSO (5 mg/mL), ethanol (5 mg/mL), chloroform, dichloromethane, DMF (5 mg/mL), alcohols, and methanol. Insoluble in water.
分子量	241.240 g/mol
XLogP3	1.800
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	2
精确质量Exact Mass	241.074 Da
单同位素质量Monoisotopic Mass	241.074 Da
拓扑极表面积Topological Polar Surface Area	47.900 Å²
重原子数Heavy Atom Count	18
形式电荷Formal Charge	0
复杂度Complexity	450.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

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批号(Lot Number)	证书类型	货号
L2418688	分析证书	R131523
F1501130	分析证书	R131523
L1811136	分析证书	R131523

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引用文献

1. Wei Liu, Mi Zhang, Yan Xiao, Zhaoyang Ye, Yan Zhou, Meidong Lang, Wen-Song Tan. (2020) Fabrication and in vitro evaluation of a packed-bed bioreactor based on galactosylated poly(ethylene terephthalate) microfibrous scaffolds. BIOCHEMICAL ENGINEERING JOURNAL, 160 (107565). [10.1016/j.bej.2020.107565]
2. Tongtong Shen, Yufan Miao, Chenchen Ding, Wentao Fan, Shuhui Liu, Yanan Lv, Xiaona Gao, Marthe De Boevre, Liping Yan, Sheila Okoth, Sarah De Saeger, Suquan Song. (2019) Activation of the p38/MAPK pathway regulates autophagy in response to the CYPOR-dependent oxidative stress induced by zearalenone in porcine intestinal epithelial cells. FOOD AND CHEMICAL TOXICOLOGY, 131 (110527). [PMID:31173817] [10.1016/j.fct.2019.05.035]
3. Yingchang Song, Jiayu Zeng, Jianglan Long, Aiting Wang, Kuan Chen, Jia'an Qin, Dan Yan. (2024) Rapid multichannel fluorescent probe assay for CYP450 inhibition screening and drug interaction monitoring. MICROCHEMICAL JOURNAL, 198 (110185). [10.1016/j.microc.2024.110185]

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