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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| R101673-1g |
1g |
现货 ![]() |
| |
| R101673-5g |
5g |
现货 ![]() |
| |
| R101673-25g |
25g |
现货 ![]() |
|
| 别名 | 利血平 | 蛇根碱 | 血安平 | 蛇根草素 |
|---|---|
| 英文别名 | Carditivo | Eberpine | Rautrin | Reserp | Reserpil | Benazyl | Diurese-R | Eskaserp | Gilucard | Hydroserp | Reserpamed | Reserpin | Mephaserpin | Rausedyl | Riserpa | Serpate | Rausan | Reserpex | Reserpidefe | Rauserpine | Rausingle | Rauwoleaf | Reserp |
| 规格或纯度 | Moligand™, ≥98%(HPLC) |
| 英文名称 | Reserpine |
| 生化机理 | 不可逆水泡单胺转运蛋白(VMAT2)拮抗剂。持久的生物胺耗竭。防止生物胺转运到突触小泡和嗜铬颗粒中。耗尽生物胺储备。降压和抗精神病药。 |
| 应用 | 抑制儿茶酚胺(catecholamines)和5-羟色胺(serotonin)的吸收。 |
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 囊泡单胺转运体 1 抑制剂;囊泡单胺转运体 2 抑制剂 |
| 备注 | 如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| 产品介绍 |
Reserpine has displayed a capacity to inhibit the transport of biogenic amines into synaptic vesicles and adrenal chromaffin granules. The mechanism behind this inhibition has been illuminated as an irreversible binding to the vesicular amine transporter. Furthermore, Reserpine has been reported to interfere with dopamine transporter activity and potently inhibit synaptosomal dopamine uptake. Reserpine is an inhibitor of VMAT 2.抑制儿茶酚胺(catecholamines)和5-羟色胺(serotonin)的吸收。 Reserpine has displayed a capacity to inhibit the transport of biogenic amines into synaptic vesicles and adrenal chromaffin granules. The mechanism behind this inhibition has been illuminated as an irreversible binding to the vesicular amine transporter. Furthermore, Reserpine has been reported to interfere with dopamine transporter activity and potently inhibit synaptosomal dopamine uptake. Reserpine is an inhibitor of VMAT 2. |
| 纯度 | ≥98%(HPLC) |
| ALogP | 4 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504750936 |
|---|---|
| EC号 | 200-047-9 |
| 分子类型 | 小分子 |
| IIUPAC Name | methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate |
| INCHI | 1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1 |
| InChi Key | QEVHRUUCFGRFIF-MDEJGZGSSA-N |
| Smiles | COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC |
| Isomeric SMILES | CO[C@H]1[C@@H](C[C@@H]2CN3CCC4=C([C@H]3C[C@@H]2[C@@H]1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC |
| PubChem CID | 5770 |
| UN Number | 3077 |
| Packing Group | III |
| 分子量 | 608.68 |
| Beilstein号 | 102014 |
| 溶解性 | Soluble in DMSO (100 mM), chloroform (10 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C). |
|---|---|
| 密度 | 1.32 |
| 敏感性 | 对空气敏感 |
| 比旋光度 | 177° (C=1,DMF) |
| 闪点(℉) | 22 °C |
| 闪点(℃) | 22°C |
| 分子量 | 608.700 g/mol |
| XLogP3 | 4.000 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 10 |
| 可旋转键计数Rotatable Bond Count | 10 |
| 精确质量Exact Mass | 608.273 Da |
| 单同位素质量Monoisotopic Mass | 608.273 Da |
| 拓扑极表面积Topological Polar Surface Area | 118.000 Ų |
| 重原子数Heavy Atom Count | 44 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1000.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 6 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时,请勿进食、饮水或吸烟。 P330: 漱口 P301+P312: 如误吞咽:如感觉不适,呼叫急救中心/医生。 P405: 密闭存放 P411: 储存温度不超过...°C / ...°F P501: 将内容物/容器处理到。。。 |
| WGK Germany | 3 |
| Class | 9 |
| Merck Index | 8145 |
| 个人防护装备 | Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter |
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