QC6352

COA

级别和纯度:

≥99%

CAS编号: 1851373-36-8
分子式: C₂₄H₂₅N₃O₂
分子量: 387.47
PubChem编号: 118598059

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货号 (SKU)	包装规格	是否现货
Q649776-5mg	5mg	期货
Q649776-10mg	10mg	期货
Q649776-25mg	25mg	期货
Q649776-50mg	50mg	期货
Q649776-100mg	100mg	期货

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Histone Demethylase (97) Histone Modification (3105) 表观遗传学 (1497)

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基本描述

规格或纯度	≥99%
英文名称	QC6352
生化机理	QC6352 是一种可口服的选择性强效 KDM4C 抑制剂，其 IC 50 为 35 nM。
储存温度	避光,-80℃储存
运输条件	超低温冰袋运输
产品介绍	QC6352 is an orally available, selective and potent KDM4C inhibitor with an IC 50 of 35 nM In Vitro QC6352 is a potent KDM4C inhibitor with an IC 50 of 35±8 nM. In a concentration-dependent manner QC6352 dramatically reduces the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. QC6352 blocks proliferation and self-renewal of BCSCs. As shown by western blot analysis the protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo QC6352 strongly affects tumor growth and final tumor weight of both BCSC1 and BCSC2 xenografts. Treatment with QC6352 is well tolerated and does not affect body weight of the mice. Results demonstrate that treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Assay Cells are detached by Accutase and counted. 1×10 3 single BCSC1 and BCSC2 cells are seeded as triplicates in 50% Matrigel into individual wells of 24-well ultra-low attachment plates in serum-free MSC medium. After 7 days, spheres over 50 μm diameter are counted for QC6352- and QC6688-treated and control cells and spheres over 20 μm diameter are counted for paclitaxel-treated and control cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal administration Mice: When tumors reach a palpable size of 3 mm 3 , mice are treated with vehicle (control) or QC6352. The inhibitor is administered daily to mice via oral gavage at 10 mg/kg. Control animals receive vehicle only. Animals are monitored twice weekly for weight and tumor growth . aladdin has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:KDM4
纯度	≥99%

关联靶点（人）

KDM4B Tchem 赖氨酸特异性去甲基化酶4B(Lysine-specific demethylase 4B) (1 活性数据)

点击查看靶蛋白信息： KDM4B

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

KDM4C Tchem 赖氨酸特异性去甲基化酶4C(Lysine-specific demethylase 4C) (3 活性数据)

点击查看靶蛋白信息： KDM4C

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

KDM4A Tchem 赖氨酸特异性去甲基化酶4A(Lysine-specific demethylase 4A) (1 活性数据)

点击查看靶蛋白信息： KDM4A

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

KDM4D Tchem 赖氨酸特异性去甲基化酶4D(Lysine-specific demethylase 4D) (1 活性数据)

点击查看靶蛋白信息： KDM4D

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

KDM5B Tchem 赖氨酸特异性去甲基化酶5B(Lysine-specific demethylase 5B) (1 活性数据)

点击查看靶蛋白信息： KDM5B

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

Breast carcinoma cell (217 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Colon carcinoma cell (76 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KYSE-150 cell line (174 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

IMR-90 (216 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)

点击查看靶蛋白信息： KDM4A

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM4D Tchem Lysine-specific demethylase 4D (224 活性数据)

点击查看靶蛋白信息： KDM4D

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM4C Tchem Lysine-specific demethylase 4C (1129 活性数据)

点击查看靶蛋白信息： KDM4C

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM3A Tchem Lysine-specific demethylase 3A (116 活性数据)

点击查看靶蛋白信息： KDM3A

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM6B Tchem Lysine-specific demethylase 6B (280 活性数据)

点击查看靶蛋白信息： KDM6B

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PHF8 Tchem Histone lysine demethylase PHF8 (151 活性数据)

点击查看靶蛋白信息： PHF8

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM4B Tchem Lysine-specific demethylase 4B (165 活性数据)

点击查看靶蛋白信息： KDM4B

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM5B Tchem Lysine-specific demethylase 5B (814 活性数据)

点击查看靶蛋白信息： KDM5B

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

KDM2B Tchem Lysine-specific demethylase 2B (347 活性数据)

点击查看靶蛋白信息： KDM2B

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Mus musculus (284745 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	3-[[(1R)-6-(N-methylanilino)-1,2,3,4-tetrahydronaphthalen-1-yl]methylamino]pyridine-4-carboxylic acid
INCHI	1S/C24H25N3O2/c1-27(19-8-3-2-4-9-19)20-10-11-21-17(14-20)6-5-7-18(21)15-26-23-16-25-13-12-22(23)24(28)29/h2-4,8-14,16,18,26H,5-7,15H2,1H3,(H,28,29)/t18-/m0/s1
InChi Key	XSMABFRQESMONQ-SFHVURJKSA-N
Smiles	CN(C1=CC=CC=C1)C2=CC3=C(C=C2)C(CCC3)CNC4=C(C=CN=C4)C(=O)O
Isomeric SMILES	CN(C1=CC=CC=C1)C2=CC3=C(C=C2)[C@@H](CCC3)CNC4=C(C=CN=C4)C(=O)O
PubChem CID	118598059
MeSH Entry Terms	QC6352
分子量	387.47

化学和物理性质

溶解性	DMSO : 16.67 mg/mL (43.02 mM; Need ultrasonic)
分子量	387.500 g/mol
XLogP3	5.300
氢键供体数Hydrogen Bond Donor Count	2
氢键受体数Hydrogen Bond Acceptor Count	5
可旋转键计数Rotatable Bond Count	6
精确质量Exact Mass	387.195 Da
单同位素质量Monoisotopic Mass	387.195 Da
拓扑极表面积Topological Polar Surface Area	65.500 Å²
重原子数Heavy Atom Count	29
形式电荷Formal Charge	0
复杂度Complexity	536.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	1
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

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C of A & Other Certificates(BSE/TSE, COO):

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