| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Q421202-1ml |
1ml |
现货  |
|
| 英文别名 | Quinine | 130-95-0 | Chinin | Chinine | (-)-Quinine | 6'-Methoxycinchonidine | (8S,9R)-Quinine | Qualaquin | Quinine anhydrous | (R)-(-)-quinine | chininum | quinina | Quinine, Anhydrous | 6-Methoxycinchonine | Rezquin | Chininum purum | quinine bisulphate | Quinoline alkaloid | quinine sul |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Quinine |
| 生化机理 | 钾通道阻断剂。 |
| 储存温度 | 避光,-80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | TAS2R14 激动剂;TAS2R40 激动剂;K 2P18.1 通道阻断剂;K v2.2 通道阻断剂;质膜单胺转运体抑制剂 |
| 产品介绍 |
Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant. Quinine is a primary alkaloid of various species of Cinchona, optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 205-003-2 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol |
| INCHI | 1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1 |
| InChi Key | LOUPRKONTZGTKE-WZBLMQSHSA-N |
| Smiles | COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O |
| Isomeric SMILES | COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O |
| 分子量 | 324.42 |
| Beilstein号 | 91867 |
| Reaxy-Rn | 91864 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=91864&ln= |
| 敏感性 | 对光线、湿度敏感 |
|---|---|
| 熔点 | 173-177°C |
| 分子量 | 324.400 g/mol |
| XLogP3 | 2.900 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 324.184 Da |
| 单同位素质量Monoisotopic Mass | 324.184 Da |
| 拓扑极表面积Topological Polar Surface Area | 45.600 Ų |
| 重原子数Heavy Atom Count | 24 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 457.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H302: 吞食有害 H315: 引起皮肤刺激 H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P272: 被污染的工作服不允许离开工作场所 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P284: 如果通风不良，请佩戴呼吸防护装置。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P342+P316: 如果出现呼吸道症状：立即寻求急救。 |
| WGK Germany | 3 |
| RTECS | VA6020000 |
| Merck Index | 8061 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| 1. Qing Li, Yu-Meng Guo, Xiang-Yi He, Guang-Li Li. (2023) Bifunctional Cu(II)-containing PDA-PEI copolymer dots: Demonstration of a dual-mode platform for colorimetric-fluorescent detection of glyphosate in the environment. TALANTA, 265 (124865). [PMID:37418960] [10.1016/j.talanta.2023.124865] |
| 2. Wu Xiao-yan, Lv Jin-yan, Zhang Shi-qing, Yi Xin, Xu Zi-wei, Zhi Yuan-xing, Zhao Bo-xin, Pang Jian-xin, Yung Ken Kin Lam, Liu Shu-wen, Zhou Ping-zheng. (2021) ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. ACTA PHARMACOLOGICA SINICA, 43 (4): (992-1000). [PMID:34341510] [10.1038/s41401-021-00739-9] |
| 3. Jun Yang, Hao Guo, Nan-Ji Jiang, Rui Tang, Guo-Cheng Li, Ling-Qiao Huang, Joop J. A. van Loon, Chen-Zhu Wang. (2021) Identification of a gustatory receptor tuned to sinigrin in the cabbage butterfly Pieris rapae. PLoS Genetics, 17 (7): (e1009527). [PMID:34264948] [10.1371/journal.pgen.1009527] |
| 4. Lin Yali, Liu Yu, Li Siqi, Rui Lili, Ou Jiming, Wu Quanzhou, He Jianfeng. (2021) Template-directed preparation of three-dimensionally ordered macroporous molecularly imprinted microspheres for selective recognition and separation of quinine from cinchona extract. JOURNAL OF POLYMER RESEARCH, 28 (5): (1-10). [10.1007/s10965-021-02533-x] |
| 5. Huan-Huan Ding, Mu-Han Zhao, Le Zhai, Jian-Bin Zhen, Le-Yun Sun, Jia-Zhu Chigan, Cheng Chen, Jia-Qi Li, Han Gao, Ke-Wu Yang. (2021) A quinine-based quaternized polymer: a potent scaffold with bactericidal properties without resistance. Polymer Chemistry, 12 (16): (2397-2403). [10.1039/D0PY01751E] |
| 6. Zhi-Yuan Zhang, Li-Li Rui, Ya-Li Lin, Hui-Dan Zhang, Ji-Ming Ou, Jian-Feng He, Quan-Zhou Wu. (2021) Preparation of ordered macroporous molecularly imprinted polymers and their applications in purifying cinchona alkaloids from cinchona extract. POLYMER INTERNATIONAL, 70 (9): (1344-1355). [10.1002/pi.6205] |
| 7. Pengli Zuo, Zhongguang Chen, Fengling Yu, Jinyu Zhang, Wei Zuo, Yanli Gao, Qingyou Liu. (2020) An easy synthesis of nitrogen and phosphorus co-doped carbon dots as a probe for chloramphenicol. RSC Advances, 10 (54): (32919-32926). [PMID:35516483] [10.1039/D0RA04228E] |
| 8. Hang Zhou, Jia Chen, Hui Li, Kaijun Quan, Yingshan Zhang, Hongdeng Qiu. (2020) Imidazolium ionic liquid-enhanced poly(quinine)-modified silica as a new multi-mode chromatographic stationary phase for separation of achiral and chiral compounds. TALANTA, 211 (120743). [PMID:32070598] [10.1016/j.talanta.2020.120743] |
| 9. Yin Yu, Yongxin Tao, Baozhu Yang, Datong Wu, Yong Qin, Yong Kong. (2017) Smart Chiral Sensing Platform with Alterable Enantioselectivity. ANALYTICAL CHEMISTRY, 89 (23): (12930–12937). [PMID:29125282] [10.1021/acs.analchem.7b03783] |
| 10. Yue Wang, Wen-ting Wu, Ming-bo Wu, Hong-di Sun, Hui Xie, Chao Hu, Xue-yan Wu, Jie-shan Qiu. (2015) Yellow-visual fluorescent carbon quantum dots from petroleum coke for the efficient detection of Cu2+ ions. NEW CARBON MATERIALS, 30 (550). [10.1016/S1872-5805(15)60204-9] |
| 11. Mingbo Wu, Yue Wang, Wenting Wu, Chao Hu, Xiuna Wang, Jingtang Zheng, Zhongtao Li, Bo Jiang, Jieshan Qiu. (2014) Preparation of functionalized water-soluble photoluminescent carbon quantum dots from petroleum coke. CARBON, 78 (480). [10.1016/j.carbon.2014.07.029] |
| 12. Qing Zhang, Yihan Huang, Liju Guo, Cui Chen, Dongmei Guo, Ya Chen, Yingzi Fu. (2014) DNA-based nanocomposite as electrochemical chiral sensing platform for the enantioselective interaction with quinine and quinidine. NEW JOURNAL OF CHEMISTRY, 38 (9): (4600-4606). [10.1039/C3NJ01559A] |
| 13. Li Liu, Xuecai Tan, Xiaoxue Fang, Yuexin Sun, Fuhou Lei, Zaiyin Huang. (2012) Electrochemical Sensor Based on Molecularly Imprinted Polymer Film Prepared with Functional Abietic-Type Acids as Cross-Linker for the Determination of Quinine. ELECTROANALYSIS, 24 (7): (1647-1654). [10.1002/elan.201200085] |
| 14. Qing Wang,Jing Li,Xin Yang,Li Xu,Zhi-guo Shi,Lan-Ying Xu. (2014-08-17) Investigation on performance of zirconia and magnesia-zirconia stationary phases in hydrophilic interaction chromatography.. Talanta, 129 (438-447). [PMID:25127617] |
| 15. Liyun Ma,Simin Liu,Qing Wang,Lin Yao,Li Xu. (2015-02-03) Cucurbit(6)uril immobilized on silica: a novel high-performance liquid chromatographic stationary phase.. Journal of separation science, 38 ((7)): (1082-1089). [PMID:25641573] |
| 16. Xuyuan Sun, Hao Liu, Zhengyuan Dai, Ying Wang, Li Li, Yaping Ding. (2024) A dual-functional monomer-based molecularly imprinted fluorescent aptasensor employing near-infrared carbon dots for selective detection of quinine in food. FOOD CHEMISTRY, (142317). [PMID:39718314] [10.1016/j.foodchem.2024.142317] |
| 17. Kai Ni, Bo Che, Rong Gu, Chunhong Wang, Hongyang Xu, Huiduo Li, Shiyan Cen, Mingzhi Luo, Linhong Deng. (2024) BitterDB database analysis plus cell stiffness screening identify flufenamic acid as the most potent TAS2R14-based relaxant of airway smooth muscle cells for therapeutic bronchodilation. Theranostics, 14 (4): (1744-1763). [PMID:38389834] [10.7150/thno.92492] |
| 18. Yiqun Jiang, Zhen Luo, Fenglan Xiang, Yubin Liu, Jin Yan, Jinmei Wang. (2024) Fabrication and Encapsulation of Soy Peptide Nanoparticles Using Ultrasound Followed by Spray Drying. Foods, 13 (23): (3967). [PMID:39683039] [10.3390/foods13233967] |
| 19. Hanlin Gong, Chenglong Bao, Xuan Luo, Yongsheng Yu, Weiwei Yang. (2024) Reusable electrochemical sensor for quinine detection via β-cyclodextrin-based indicator displacement assay. MICROCHEMICAL JOURNAL, 198 (110109). [10.1016/j.microc.2024.110109] |
| 20. Chen Yang, Kaikai Wei, Minghui Xu, Zhaojun Wang, Chuanjian Cui, Qianying Dai, Guijie Chen, Ruyan Hou. (2025) Sensory wheel construction and key flavor compounds characterization of black tea milk tea beverages. FOOD CHEMISTRY, 481 (143931). [PMID:40147384] [10.1016/j.foodchem.2025.143931] |
首页
400-620-6333
20篇引用文献 
