基本描述

别名	苯并嘧啶
英文别名	FT-0631892 \| QUZ \| InChI=1/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6 \| MFCD00006712 \| J-524172 \| Benzo(a)pyrimidine \| 1,3-Diazanaphthalene \| NCIOpen2_000549 \| 1,3-Benzodiazine \| Quinazolines \| UNII-UB9QUR18NL \| Z1251332997 \| A817834 \| NSC72372 \| NSC-72372 \| S
规格或纯度	≥98%
英文名称	Quinazoline
生化机理	通过细菌 SOS 染色试验（大肠杆菌）确定了喹唑啉的遗传毒性。
应用	Usually used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.
储存温度	2-8°C储存
运输条件	冰袋运输
产品介绍	Usually used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods. Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs. Usually used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.
纯度	≥98%

关联靶点（人）

EGFR Tclin 表皮生长因子受体(Epidermal growth factor receptor) (1 活性数据)

点击查看靶蛋白信息： EGFR

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

DHFR Tclin Dihydrofolate reductase (3072 活性数据)

点击查看靶蛋白信息： DHFR

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)

点击查看靶蛋白信息： EGFR

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504751797
EC号	205-965-3
分子类型	小分子
IIUPAC Name	quinazoline
INCHI	1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H
InChi Key	JWVCLYRUEFBMGU-UHFFFAOYSA-N
Smiles	C1=CC=C2C(=C1)C=NC=N2
Isomeric SMILES	C1=CC=C2C(=C1)C=NC=N2
PubChem CID	9210
分子量	130.15
Beilstein号	109370
Reaxy-Rn	109370

化学和物理性质

溶解性	Soluble in water.
密度	1.183
敏感性	对光线敏感 ;对湿度敏感
闪点(℉)	222.8 °F
闪点(℃)	106 °C
沸点	243°C
熔点	48°C
分子量	130.150 g/mol
XLogP3	1.000
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	130.053 Da
单同位素质量Monoisotopic Mass	130.053 Da
拓扑极表面积Topological Polar Surface Area	25.800 Å²
重原子数Heavy Atom Count	10
形式电荷Formal Charge	0
复杂度Complexity	114.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
Merck Index	8053
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	货号
K2110719	分析证书	Q107983
E2014054	分析证书	Q107983
G2508109	分析证书	Q107983
H2206537	分析证书	Q107983
H2206538	分析证书	Q107983

引用文献

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3. Tarek Mohamed,Praveen P N Rao. (2016-12-13) 2,4-Disubstituted quinazolines as amyloid-β aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies.. European journal of medicinal chemistry, 126 (823-843). [PMID:27951490]
4. Bruna Possato,Victor M Deflon,Zeki Naal,André L B Formiga,Sofia Nikolaou. (2017-06-13) An extended π-system and enhanced electronic delocalization on symmetric [Ru. Dalton transactions (Cambridge, England : 2003), 46 ((24)): (7926-7938). [PMID:28604871]
5. Aylin Uslu,Süreyya Oğuz Tümay,Ahmet Şenocak,Fatma Yuksel,Elif Özcan,Serkan Yeşilot. (2017-07-04) Imidazole/benzimidazole-modified cyclotriphosphazenes as highly selective fluorescent probes for Cu. Dalton transactions (Cambridge, England : 2003), 46 ((28)): (9140-9156). [PMID:28671228]
6. Xing-Chen Chen,Xiang-Tai Wei,Jun-Hong Guan,Hong Shu,Duo Chen. (2017-10-17) EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism.. Oncotarget, 8 ((39)): (65969-65982). [PMID:29029486]
7. Snežana Rajković,Beata Warżajtis,Marija D Živković,Biljana Đ Glišić,Urszula Rychlewska,Miloš I Djuran. (2018-06-02) Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes.. Bioinorganic chemistry and applications, 2018 (3294948-3294948). [PMID:29853829]
8. Wang Liao,Xiaojie He,Zhuwen Yi,Wei Xiang,Yan Ding. (2018-09-28) Chelidonine suppresses LPS-Induced production of inflammatory mediators through the inhibitory of the TLR4/NF-κB signaling pathway in RAW264.7 macrophages.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 107 (1151-1159). [PMID:30257328]
9. Sheng-Jun Liao,Jing Luo,Dong Li,Yuan-Hong Zhou,Bin Yan,Jing-Jing Wei,Jian-Cheng Tu,Yi-Rong Li,Gui-Mei Zhang,Zuo-Hua Feng. (2019-02-11) TGF-β1 and TNF-α synergistically induce epithelial to mesenchymal transition of breast cancer cells by enhancing TAK1 activation.. Journal of cell communication and signaling, 13 ((3)): (369-380). [PMID:30739244]
10. P Saravana Kumar,P Raja Lakshmi,Kuppanagounder P Elango. (2019-06-08) Rational design and application of a fluorogenic chemodosimeter for selective detection of cyanide in an aqueous solution via excimer formation.. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 221 (117172-117172). [PMID:31174138]
11. Angela L McCleary-Wheeler,Ryan M Carr,Shanique R Palmer,Thomas C Smyrk,Jacob B Allred,Luciana L Almada,Ezequiel J Tolosa,Maria J Lamberti,David L Marks,Mitesh J Borad,Julian R Molina,Yingwei Qi,Wilma L Lingle,Axel Grothey,Henry C Pitot,Aminah Jatoi,Donald W Northfelt,Alan H Bryce,Robert R McWilliams,Scott H Okuno,Paul Haluska,George P Kim,Gerardo Colon-Otero,Val J Lowe,Matthew R Callstrom,Wen We Ma,Tanios Bekaii-Saab,Mien-Chie Hung,Charles Erlichman,Martin E Fernandez-Zapico. (2019-12-04) Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer.. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 20 ((1)): (101-109). [PMID:31787526]
12. Mohammed, et al.. (2020) The Valuable Impacts of Halophytic Genus Suaeda; Nutritional, Chemical, and Biological Values.. Medicinal Chemistry, 16 (1044-1057). [PMID:32091344]
13. Midori Takeda,Tohru Tezuka,Minsoo Kim,Jungmi Choi,Yuki Oichi,Hatasu Kobayashi,Kouji H Harada,Tsunehiro Mizushima,Shigeru Taketani,Akio Koizumi,Shohab Youssefian. (2020-03-07) Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner.. Biochemical and biophysical research communications, 525 ((3)): (668-674). [PMID:32139119]
14. Hamed W El-Shafey,Rania M Gomaa,Shahenda M El-Messery,Fatma E Goda. (2020-06-17) Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent.. Bioorganic chemistry, 101 (103987-103987). [PMID:32540783]
15. Kyle G Koch,Nathan A Palmer,Teresa Donze-Reiner,Erin D Scully,Javier Seravalli,Keenan Amundsen,Paul Twigg,Joe Louis,Jeffrey D Bradshaw,Tiffany Marie Heng-Moss,Gautam Sarath. (2020-08-28) Aphid-Responsive Defense Networks in Hybrid Switchgrass.. Frontiers in plant science, 11 (1145-1145). [PMID:32849703]
16. Ryo Hatano,Kei Ohnuma,Haruna Otsuka,Eriko Komiya,Izumi Taki,Satoshi Iwata,Nam H Dang,Ko Okumura,Chikao Morimoto. (2014-12-31) CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway.. Journal of immunology (Baltimore, Md. : 1950), 194 ((3)): (960-972). [PMID:25548232]
17. Pei-Pei Guan,Xin Yu,Jian-Jun Guo,Yue Wang,Tao Wang,Jia-Yi Li,Konstantinos Konstantopoulos,Zhan-You Wang,Pu Wang. (2015-04-01) By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.. Oncotarget, 6 ((11)): (9140-9159). [PMID:25823818]
18. Xia Hua,Xiaoyong Yuan,Zhijie Li,Terry G Coursey,Stephen C Pflugfelder,De-Quan Li. (2015-06-04) A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.. PloS one, 10 ((6)): (e0128039-e0128039). [PMID:26039076]
19. Zixing Liu,Kelly R Smith,Hung T Khong,Jingshan Huang,Eun-Young Erin Ahn,Ming Zhou,Ming Tan. (2016-09-17) miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20.. Oncotarget, 7 ((48)): (78667-78679). [PMID:27637078]
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21. Elham Bagheri,Kamelia Saremi,Fatemeh Hajiaghaalipour,Fadhil Lafta Faraj,Hapipah Mohd Ali,Mahmood Ameen Abdulla,Si Lay Khaing,Nur Ain Salehen. (2018-02-01) Synthesis of Novel Derivatives of Quinazoline Schiff base Compound Promotes Epithelial Wound Healing.. Current pharmaceutical design, 24 ((13)): (1395-1404). [PMID:29384057]
22. Zhijiang Fan,Jun Shi,Xiaoping Bao. (2018-03-27) Synthesis and antimicrobial evaluation of novel 1,2,4-triazole thioether derivatives bearing a quinazoline moiety.. Molecular diversity, 22 ((3)): (657-667). [PMID:29574502]
23. Siva Jyothi Buggana,Mani Chandrika Paturi,Harathi Perka,Deepak Reddy Gade,Rajendra Prasad Vvs. (2019-02-21) Novel 2,4-disubstituted quinazolines as cytotoxic agents and JAK2 inhibitors: Synthesis, in vitro evaluation and molecular dynamics studies.. Computational biology and chemistry, 79 (110-118). [PMID:30785020]
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溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

=

浓度

x

体积

x

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

x

体积 1 (V1)

=

浓度 2 (C2)

x

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

=

质量（小瓶）

÷

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
Q107983-1g	1g	现货
Q107983-5g	5g	现货
Q107983-25g	25g	现货

喹唑啉

库存信息

库存信息

库存信息

基本描述

关联靶点（人）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器