| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P649475-10mg |
10mg |
期货  |
| |
| P649475-5mg |
5mg |
期货 |
|
| 别名 | PROTAC Sirt2降解剂-1 |
|---|---|
| 规格或纯度 | ≥98% |
| 英文名称 | PROTAC Sirt2 Degrader-1 |
| 生化机理 | PROTAC Sirt2 降解剂-1 是一种基于 SirReal 的 PROTAC ，可作为 Sirt2 降解剂，由一种高效的同种型选择性 Sirt2 抑制剂、连接体和一种真正的 E3 泛素连接酶 Cereblon 配体组成。PROTAC Sirt2 降解剂-1 的 IC 50 为 0.5 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC , acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC 50 of 0.25 μM for Sirt2 , with no effect on Sirt1/Sirt3 (IC 50 s>100 μM) In Vitro PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: HeLa cells Concentration: 10 µM Incubation Time: 1-6 hours Result: Caused Sirt2 degradation, but showed no effect on Sirt1 levels. Form:Solid IC50& Target:SIRT2 0.25 μM (IC 50 ) |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | N-[4-[4-[[3-[[2-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]-1,3-thiazol-5-yl]methyl]phenoxy]methyl]triazol-1-yl]butyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide |
| INCHI | 1S/C40H40N10O8S2/c1-23-15-24(2)44-40(43-23)59-22-34(53)46-39-42-18-28(60-39)17-25-7-5-8-27(16-25)57-20-26-19-49(48-47-26)14-4-3-13-41-33(52)21-58-31-10-6-9-29-35(31)38(56)50(37(29)55)30-11-12-32(51)45-36(30)54/h5-10,15-16,18-19,30H,3-4,11-14,17,20-22H2,1-2H3,(H,41,52)(H,42,46,53)(H,45,51,54) |
| InChi Key | GRYRXFYWVDWPQY-UHFFFAOYSA-N |
| Smiles | CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C |
| Isomeric SMILES | CC1=CC(=NC(=N1)SCC(=O)NC2=NC=C(S2)CC3=CC(=CC=C3)OCC4=CN(N=N4)CCCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C |
| PubChem CID | 135397670 |
| 分子量 | 852.94 |
| 溶解性 | DMSO : ≥ 100 mg/mL (117.24 mM) |
|---|---|
| 分子量 | 852.900 g/mol |
| XLogP3 | 3.200 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 15 |
| 可旋转键计数Rotatable Bond Count | 18 |
| 精确质量Exact Mass | 852.247 Da |
| 单同位素质量Monoisotopic Mass | 852.247 Da |
| 拓扑极表面积Topological Polar Surface Area | 283.000 Ų |
| 重原子数Heavy Atom Count | 60 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1540.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
首页
400-620-6333
