PF-03463275

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货号 (SKU)	包装规格	是否现货
P649439-5mg	5mg	期货
P649439-10mg	10mg	期货
P649439-50mg	50mg	期货

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GlyT (21) 神经元信号传导 (3320) 膜转运体 (1142) 膜转运器/离子通道 (1829)

基本描述

英文别名	1-Methyl-1H-imidazole-4-carboxylic acid(3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide \| N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide \| 117323
规格或纯度	≥99%
英文名称	PF-03463275
生化机理	PF-03463275 是一种中枢渗透性、口服型、选择性和竞争性 GlyT1（甘氨酸转运体-1）可逆抑制剂，其 K i 为 11.6 nM。PF-03463275 具有研究精神分裂症的潜力。
储存温度	-20°C储存
运输条件	超低温冰袋运输
作用类型	抑制剂
产品介绍	PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a K i of 11.6 nM. PF-03463275 has the potential for Schizophrenia research. In Vivo PF-03463275 (1-10 mg/kg; s.c.) attenuates oscillatory potentials (OPs). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley ratsDosage: 1, 3 and 10 mg/kg Administration: S.c. Result: A dose-dependent reduction in the amplitude of oscillatory potentials (OPs) elicited from the dark-adapted rats. Form:Solid
纯度	≥99%

SLC6A9 Tchem 钠和氯依赖性甘氨酸转运蛋白 1(Sodium- and chloride-dependent glycine transporter 1) (1 活性数据)

点击查看靶蛋白信息： SLC6A9

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

KCNH2 Tclin HERG (29587 活性数据)

点击查看靶蛋白信息： KCNH2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC6A5 Tchem Glycine transporter 2 (697 活性数据)

点击查看靶蛋白信息： SLC6A5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Slc6a9 Glycine transporter 1 (255 活性数据)

点击查看靶蛋白信息： Slc6a9

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MDCK (10148 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

分子类型	小分子
IIUPAC Name	N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]imidazole-4-carboxamide
INCHI	1S/C19H22ClFN4O/c1-23-7-13-14(8-23)15(13)9-25(19(26)18-10-24(2)11-22-18)6-12-3-4-17(21)16(20)5-12/h3-5,10-11,13-15H,6-9H2,1-2H3/t13-,14+,15?
InChi Key	KYLOBHXXQOZRKK-YIONKMFJSA-N
Smiles	CN1CC2C(C1)C2CN(CC3=CC(=C(C=C3)F)Cl)C(=O)C4=CN(C=N4)C
Isomeric SMILES	CN1C[C@@H]2[C@H](C1)C2CN(CC3=CC(=C(C=C3)F)Cl)C(=O)C4=CN(C=N4)C
关联CAS	1173239-39-8
PubChem CID	44156901
MeSH Entry Terms	1-methyl-1H-imidazole-4-carboxylic acid (3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo(3.1.0) hex-6-ylmethyl)amide;PF-03463275;PF-3463275
分子量	376.86

溶解性	DMSO : 33.33 mg/mL (88.44 mM; Need ultrasonic)
分子量	376.900 g/mol
XLogP3	2.400
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	5
精确质量Exact Mass	376.147 Da
单同位素质量Monoisotopic Mass	376.147 Da
拓扑极表面积Topological Polar Surface Area	41.400 Å²
重原子数Heavy Atom Count	26
形式电荷Formal Charge	0
复杂度Complexity	526.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	2
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1