PBOX 6

COA

级别和纯度:

≥99%

CAS编号: 290814-68-5
分子式: C₂₅H₂₀N₂O₃
分子量: 396.44
PubChem编号: 9865511

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货号 (SKU)	包装规格	是否现货
P648174-5mg	5mg	期货
P648174-10mg	10mg	期货
P648174-25mg	25mg	期货
P648174-50mg	50mg	期货
P648174-100mg	100mg	期货

查看相关系列

Apoptosis (7108) Cell Cycle (7376) Cell Cycle/DNA Damage (2603) Cytoskeleton (497) Microtubule/Tubulin (197)

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基本描述

英文别名	PBOX-6 \| 7-[(N,N-dimethylcarbamoyl)oxy]-6-(naphth-1-yl)pyrrolo[2,1-d][1,5]benzoxazepine \| MS-26682 \| HY-U00446 \| Carbamic acid, N,N-dimethyl-, 6-(1-naphthalenyl)pyrrolo(2,1-d)(1,5)benzoxazepin-7-yl ester \| AKOS040742367 \| PBOX 6 \| pyrrolo-1,5-benzoxazepin
规格或纯度	≥99%
英文名称	PBOX 6
生化机理	PBOX 6 是一种吡咯-1,5-苯并氧氮杂卓（PBOX）化合物，具有微管解聚剂和细胞凋亡剂的作用。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule -depolymerizing agent and an apoptotic agent. In Vitro PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line. PBOX 6 (0-25 μM, 16 h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10 μM in HL-60 cells. PBOX 6 (10 μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10 μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Apoptosis, Microtubule
纯度	≥99%

关联靶点（人）

Ca9-22 (362 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

IIUPAC Name	(6-naphthalen-1-ylpyrrolo[2,1-d][1,5]benzoxazepin-7-yl) N,N-dimethylcarbamate
INCHI	1S/C25H20N2O3/c1-26(2)25(28)30-24-21-14-8-16-27(21)20-13-5-6-15-22(20)29-23(24)19-12-7-10-17-9-3-4-11-18(17)19/h3-16H,1-2H3
InChi Key	SOIZAFVNIXAZFQ-UHFFFAOYSA-N
Smiles	CN(C)C(=O)OC1=C(OC2=CC=CC=C2N3C1=CC=C3)C4=CC=CC5=CC=CC=C54
Isomeric SMILES	CN(C)C(=O)OC1=C(OC2=CC=CC=C2N3C1=CC=C3)C4=CC=CC5=CC=CC=C54
PubChem CID	9865511
分子量	396.44

化学和物理性质

溶解性	DMSO : 33.33 mg/mL (84.07 mM; Need ultrasonic)
分子量	396.400 g/mol
XLogP3	4.800
氢键供体数Hydrogen Bond Donor Count	0
氢键受体数Hydrogen Bond Acceptor Count	3
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	396.147 Da
单同位素质量Monoisotopic Mass	396.147 Da
拓扑极表面积Topological Polar Surface Area	43.700 Å²
重原子数Heavy Atom Count	30
形式电荷Formal Charge	0
复杂度Complexity	675.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

RIDADR	NONHforallmodesoftransport

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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