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11篇引用文献 
G23121139
计算溶液所需的质量、体积或浓度。
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基本描述
| 英文别名 | L-glutamic acid | GLUTAMIC ACID | 56-86-0 | L-glutamate | (2S)-2-Aminopentanedioic acid | (S)-2-Aminopentanedioic acid | Glutamidex | Glutaminol | H-Glu-OH | glutacid | Aciglut | Glutamicol | Glutaton | L-Glutaminic acid | (S)-Glutamic acid | glutaminic acid | Glusate | L-glu | Acidum gluta | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 稳定性与储存 | 产品充氩储存、避光、-20℃以下保存。 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 英文名称 | Poly(L-glutamic acid) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 储存温度 | 避光,-20°C储存,充氩 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 运输条件 | 超低温冰袋运输 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 产品介绍 |
聚-L-谷氨酸是一种合成聚氨基酸。每个谷氨酸单元具有一个 COOH 官能团。 聚-L-谷氨酸的应用包括与活性分子结合以提高活性，以及用于表面涂层的逐层沉积技术。 产品规格参数表:
Poly-L-glutamic acid is a synthetic polyamino acid having one COOH function per glutamic acid unit.Applications for poly-L-glutamic acid include the conjugation to active molecules for improved activities and the layer-by-layer deposition techniques for surface coating. Product Specification Reference Number：
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产品属性
| ALogP | -3.7 |
|---|
关联靶点（人）
SLC1A1
Tchem
兴奋性氨基酸转运体3(Excitatory amino acid transporter 3)
(1 活性数据)
GRIA4
Tclin
谷氨酸受体 4(Glutamate receptor 4)
(5 活性数据)
GRIK5
Tclin
谷氨酸受体离子型，海人酸 5(Glutamate receptor ionotropic, kainate 5)
(3 活性数据)
GRIK1
Tclin
谷氨酸受体离子型，海人酸 1(Glutamate receptor ionotropic, kainate 1)
(2 活性数据)
GRIA2
Tclin
谷氨酸受体 2(Glutamate receptor 2)
(5 活性数据)
GRIA3
Tclin
谷氨酸受体 3(Glutamate receptor 3)
(1 活性数据)
GRIK2
Tclin
谷氨酸受体离子型，海人酸 2(Glutamate receptor ionotropic, kainate 2)
(2 活性数据)
GRIK3
Tclin
谷氨酸受体离子型，海人酸 3(Glutamate receptor ionotropic, kainate 3)
(2 活性数据)
GRM2
Tchem
代谢型谷氨酸受体 2(Metabotropic glutamate receptor 2)
(0 活性数据)
GRM5
Tchem
代谢型谷氨酸受体 5(Metabotropic glutamate receptor 5)
(0 活性数据)
GRM7
Tchem
代谢型谷氨酸受体 7(Metabotropic glutamate receptor 7)
(0 活性数据)
GRM8
Tchem
代谢型谷氨酸受体 8(Metabotropic glutamate receptor 8)
(1 活性数据)
GRIA1
Tclin
谷氨酸受体 1(Glutamate receptor 1)
(4 活性数据)
GRM3
Tchem
代谢型谷氨酸受体 3(Metabotropic glutamate receptor 3)
(2 活性数据)
GRM6
Tchem
代谢型谷氨酸受体 6(Metabotropic glutamate receptor 6)
(0 活性数据)
F2
Tclin
Thrombin
(11687 活性数据)
CA2
Tclin
Carbonic anhydrase II
(17698 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
ADRB2
Tclin
Beta-2 adrenergic receptor
(11824 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
HTR2C
Tclin
Serotonin 2c (5-HT2c) receptor
(11471 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
PDE3A
Tclin
Phosphodiesterase 3A
(3309 活性数据)
FOLH1
Tclin
Glutamate carboxypeptidase II
(711 活性数据)
HTR2B
Tclin
Serotonin 2b (5-HT2b) receptor
(10323 活性数据)
TBXA2R
Tclin
Thromboxane A2 receptor
(5717 活性数据)
PDE4A
Tclin
Phosphodiesterase 4A
(1943 活性数据)
ADORA3
Tchem
Adenosine A3 receptor
(15931 活性数据)
GRM3
Tchem
Metabotropic glutamate receptor 3
(732 活性数据)
CA1
Tclin
Carbonic anhydrase I
(13240 活性数据)
CHAT
Tchem
Choline acetylase
(63 活性数据)
HRH3
Tclin
Histamine H3 receptor
(10389 活性数据)
GRIA3
Tclin
Glutamate receptor ionotropic, AMPA 3
(127 活性数据)
KDR
Tclin
Vascular endothelial growth factor receptor 2
(20924 活性数据)
GRM4
Tchem
Metabotropic glutamate receptor 4
(2320 活性数据)
GRM6
Tchem
Metabotropic glutamate receptor 6
(361 活性数据)
GRIA1
Tclin
Glutamate receptor ionotropic, AMPA 1
(277 活性数据)
GRIA2
Tclin
Glutamate receptor ionotropic, AMPA 2
(847 活性数据)
GRIK3
Tclin
Glutamate receptor ionotropic kainate 3
(50 活性数据)
GRM1
Tchem
Metabotropic glutamate receptor 1
(2309 活性数据)
GRM5
Tchem
Metabotropic glutamate receptor 5
(5733 活性数据)
CYP2D6
Tclin
Cytochrome P450 2D6
(33882 活性数据)
SLC1A1
Tchem
Excitatory amino acid transporter 3
(527 活性数据)
SLC1A3
Tchem
Excitatory amino acid transporter 1
(586 活性数据)
GRIK5
Tclin
Glutamate receptor ionotropic kainate 5
(45 活性数据)
ACLY
Tclin
ATP-citrate synthase
(168 活性数据)
GRIK1
Tclin
Glutamate receptor ionotropic kainate 1
(340 活性数据)
CYP1A2
Tchem
Cytochrome P450 1A2
(26471 活性数据)
GSR
Tclin
Glutathione reductase
(335 活性数据)
PIN1
Tchem
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(36611 活性数据)
关联靶点（其它种属）
tetX
Tetanus toxin (50 活性数据)
Slc17a1
Renal sodium-dependent phosphate transport protein 1 (33 活性数据)
Grm2
Metabotropic glutamate receptor 2 (1326 活性数据)
Grm8
Metabotropic glutamate receptor 8 (169 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
Gria4
Glutamate receptor ionotropic, AMPA 4 (112 活性数据)
Grik2
Glutamate receptor ionotropic kainate 2 (298 活性数据)
Slc1a2
Excitatory amino acid transporter 2 (39 活性数据)
Grm7
Metabotropic glutamate receptor 7 (580 活性数据)
murI
Glutamate racemase (2 活性数据)
dapA
Dihydrodipicolinate synthase (65 活性数据)
Canis familiaris (36305 活性数据)
Rattus norvegicus (775804 活性数据)
CHO (4503 活性数据)
Slc1a6
Excitatory amino acid transporter 4 (71 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Txnrd1
Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
Plasma (328 活性数据)
ffp
4'-phosphopantetheinyl transferase ffp (24982 活性数据)
Grin1
Glutamate NMDA receptor (6467 活性数据)
Slc16a10
Monocarboxylate transporter 10 (73 活性数据)
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
Gria2
Glutamate receptor ionotropic, AMPA (2103 活性数据)
Grik1
Glutamate receptor ionotropic, kainate (722 活性数据)
Grin1
Glutamate NMDA receptor; Grin1/Grin2b (1028 活性数据)
Grin1
Glutamate receptors; NMDA/AMPA (104 活性数据)
Grin1
Glutamate NMDA receptor; Grin1/Grin2a (798 活性数据)
Grin1
Glutamate NMDA receptor; Grin1/Grin2c (1127 活性数据)
Vicia faba (57 活性数据)
GAP1
General amino-acid permease GAP1 (481 活性数据)
Gria2
Glutamate receptor AMPA 1/2 (4 活性数据)
Carbonic anhydrase-like protein, putative (25 活性数据)
SARS-CoV-2 (38078 活性数据)
A085R
Prolyl 4-hydroxylase (72 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (2S)-2-aminopentanedioic acid |
| INCHI | 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1 |
| InChi Key | WHUUTDBJXJRKMK-VKHMYHEASA-N |
| Smiles | C(CC(=O)O)C(C(=O)O)N |
| Isomeric SMILES | C(CC(=O)O)[C@@H](C(=O)O)N |
| Reaxy-Rn | 1723799 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1723799&ln= |
化学和物理性质
| 敏感性 | 对光线敏感 |
|---|---|
| 分子量 | 147.130 g/mol |
| XLogP3 | -3.700 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 4 |
| 精确质量Exact Mass | 147.053 Da |
| 单同位素质量Monoisotopic Mass | 147.053 Da |
| 拓扑极表面积Topological Polar Surface Area | 101.000 Ų |
| 重原子数Heavy Atom Count | 10 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 145.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS05 |
|---|---|
| 信号词 | 危险 |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Jierui Yang, Huiting Qiu, Shuang Meng, Yunhui Yang. (2024) A sensing platform for ascorbic acid based on the spatial confinement of covalent organic frameworks. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 308 (123687). [PMID:38042123] [10.1016/j.saa.2023.123687] |
| 2. Zhihui Wang, Yilin Liang, Chenxi Gao, Weiwei Wu, Jiumei Kong, Zhe Zhou, Zhihua Wang, Yan Huang, Weijiang Sun. (2024) The flavor characteristics and antioxidant capability of aged Jinhua white tea and the mechanisms of its dynamic evolution during long-term aging. FOOD CHEMISTRY, 436 (137705). [PMID:37839126] [10.1016/j.foodchem.2023.137705] |
| 3. Wenjing Wang, Yumin He, Lei Deng, Hui Wang, Xiaoying Liu, Qing-wen Gui, Zhong Cao, Zemeng Feng, Benhai Xiong, Yulong Yin. (2023) Peptide aptamer-based polyaniline-modified amperometric biosensor for L-lysine detection in real serum samples. MEASUREMENT, 221 (113468). [10.1016/j.measurement.2023.113468] |
| 4. Linjie Guan, Meiyu Liu, Honghai Liu, Li Zhang, Yiming Zhang, Yucai Qin, Binbin He, Yi Mei, Yun Zu. (2023) Regionally spatial framework Al distribution in MFI channels and its impact on the n-butane cracking reaction pathways. FUEL, 353 (129230). [10.1016/j.fuel.2023.129230] |
| 5. Xiaoyao Wei, Tao Lin, Le Wang, Jiacheng Lin, Xuefeng Yin. (2023) Research on deep eutectic solvents for the construction of humidity-responsive cellulose nanocrystal composite films. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 235 (123805). [PMID:36863669] [10.1016/j.ijbiomac.2023.123805] |
| 6. Lijun Kuang, Jinghuan Huang, Yutong Liu, Xiaolin Li, Yuan Yuan, Changsheng Liu. (2021) Injectable Hydrogel with NIR Light-Responsive, Dual-Mode PTH Release for Osteoregeneration in Osteoporosis. ADVANCED FUNCTIONAL MATERIALS, 31 (47): (2105383). [10.1002/adfm.202105383] |
| 7. Chu Youqun, Huang Zhangkao, Wang Xinhang, Zhou Menglei, Zhao Fengming. (2020) Highly dispersed silver imbedded into TiN submicrospheres for electrochemical detecting of hydrogen peroxide. Scientific Reports, 10 (1): (1-12). [PMID:33335264] [10.1038/s41598-020-79286-y] |
| 8. Guihua Zhang, Ying Yu, Manli Guo, Bixia Lin, Li Zhang. (2019) A sensitive determination of albumin in urine by molecularly imprinted electrochemical biosensor based on dual-signal strategy. SENSORS AND ACTUATORS B-CHEMICAL, 288 (564). [10.1016/j.snb.2019.03.042] |
| 9. Fengna Xi, Lingli Xuan, Lili Lu, Jie Huang, Fei Yan, Jiyang Liu, Xiaoping Dong, Peng Chen. (2019) Improved adhesion and performance of vertically-aligned mesoporous silica-nanochannel film on reduced graphene oxide for direct electrochemical analysis of human serum. SENSORS AND ACTUATORS B-CHEMICAL, 288 (133). [10.1016/j.snb.2019.02.115] |
| 10. Lijun Kuang,Xiaoyu Ma,Yifan Ma,Yuan Yao,Muhammad Tariq,Yuan Yuan,Changsheng Liu. (2019-04-23) Self-Assembled Injectable Nanocomposite Hydrogels Coordinated by in Situ Generated CaP Nanoparticles for Bone Regeneration.. ACS applied materials & interfaces, 11 ((19)): (17234-17246). [PMID:31008576] |
| 11. Wei Liu, Kangcheng Zhao, Feng Chen, Chenkai Cai, Tianyuan Jiang, Liying Zhu, Chunyang Yu, Fang Liu, Muyu Yu. (2025) Supermolecular poly-N-acryloyl glycinamide/polyglutamic acid/Fe3+ hydrogel incorporated with bioactive small extracellular vesicles promote diabetic wound healing by suppressing ferroptosis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, (142313). [PMID:40147651] [10.1016/j.ijbiomac.2025.142313] |