计算溶液所需的质量、体积或浓度。
This is a demo store. No orders will be fulfilled.
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P464170-5mg |
5mg |
期货 ![]() |
| |
| P464170-25mg |
25mg |
期货 ![]() |
|
| 别名 | 3,7,11,15-四甲基十六碳酸 | 植烷酸 |
|---|---|
| 英文别名 | NSC 108698 | BDBM119875 | UNII-8OYE5TF5VL | HY-113067 | 3,7,11,15-tetramethyl-1-hexadecanoic acid | NSC 108698 | AS-82571 | J-008329 | SCHEMBL7888 | C01607 | 8OYE5TF5VL | 3,7,11,15-tetramethylhexadecoanoate | Phytanate | DTXSID80864526 | Phytanoic acid | |
| 规格或纯度 | Moligand™, ≥96%, mixture of isomers |
| 英文名称 | Phytanic acid |
| 储存温度 | 2-8°C储存 |
| 运输条件 | 冰袋运输 |
| 纯度 | ≥96% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 未知 |
|---|---|
| IIUPAC Name | 3,7,11,15-tetramethylhexadecanoic acid |
| INCHI | 1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22) |
| InChi Key | RLCKHJSFHOZMDR-UHFFFAOYSA-N |
| Smiles | CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)O |
| Isomeric SMILES | CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)O |
| PubChem CID | 26840 |
| 分子量 | 312.53 |
| Beilstein号 | 1789963 |
| 溶解性 | 0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid),DMF: >100 mg/ml (from Oleic Acid),DMSO: >100 mg/ml (from Oleic Acid),Ethanol: >100 mg/ml (from Oleic Acid),PBS pH 7.2: <100 µ g/ml (from Oleic Acid) |
|---|---|
| 折光率 | n20D1.45 (Predicted) |
| 沸点 | 78° C |
| 分子量 | 312.500 g/mol |
| XLogP3 | 8.300 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 14 |
| 精确质量Exact Mass | 312.303 Da |
| 单同位素质量Monoisotopic Mass | 312.303 Da |
| 拓扑极表面积Topological Polar Surface Area | 37.300 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 273.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 3 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理(请参阅此标签上的...)。 P302+P352: 如皮肤沾染:用水充分清洗。 P304+P340: 如误吸入:将人转移到空气新鲜处,保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续:寻求医疗帮助。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 P319: 如果你感到不适,请寻求医疗帮助。 |
| WGK Germany | 3 |
| 1. B Molzer,M Kainz-Korschinsky,R Sundt-Heller,H Bernheimer. (1989-05-01) Phytanic acid and very long chain fatty acids in genetic peroxisomal disorders.. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 27 ((5)): (309-314). [PMID:2474624] |
| 2. E L Berson. (1982-01-01) Nutrition and retinal degenerations. Vitamin A, taurine, ornithine, and phytanic acid.. Retina (Philadelphia, Pa.), 2 ((4)): (236-255). [PMID:6101131] |
| 3. K Pahan,I Singh. (1993-10-25) Intraorganellar localization of CoASH-independent phytanic acid oxidation in human liver peroxisomes.. FEBS letters, 333 ((1-2)): (154-158). [PMID:8224157] |
| 4. P A Watkins,W W Chen,C J Harris,G Hoefler,S Hoefler,D C Blake,A Balfe,R I Kelley,A B Moser,M E Beard. (1989-03-01) Peroxisomal bifunctional enzyme deficiency.. The Journal of clinical investigation, 83 ((3)): (771-777). [PMID:2921319] |
| 5. P Schönfeld,H Struy. (1999-09-03) Refsum disease diagnostic marker phytanic acid alters the physical state of membrane proteins of liver mitochondria.. FEBS letters, 457 ((2)): (179-183). [PMID:10471774] |
| 6. G Bernscherer,E Berényi,C Karabélyos,A László,Z Dávid,K Hollódy,E Z Tóth. (2000-02-16) [Refsum disease].. Orvosi hetilap, 141 ((1)): (31-34). [PMID:10673856] |
| 7. S P Young,A W Johnson,D P Muller. (2001-11-29) Effects of phytanic acid on the vitamin E status, lipid composition and physical properties of retinal cell membranes: implications for adult Refsum disease.. Clinical science (London, England : 1979), 101 ((6)): (697-705). [PMID:11724659] |
| 8. Manuel Heim,James Johnson,Franziska Boess,Igor Bendik,Peter Weber,Willi Hunziker,Beat Fluhmann. (2002-03-30) Phytanic acid, a natural peroxisome proliferator-activated receptor (PPAR) agonist, regulates glucose metabolism in rat primary hepatocytes.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 ((7)): (718-720). [PMID:11923221] |
| 9. Ronald J A Wanders,Gerbert A Jansen,Matthew D Lloyd. (2003-03-14) Phytanic acid alpha-oxidation, new insights into an old problem: a review.. Biochimica et biophysica acta, 1631 ((2)): (119-135). [PMID:12633678] |
| 10. J C Komen,M Duran,R J A Wanders. (2005-06-28) Characterization of phytanic acid omega-hydroxylation in human liver microsomes.. Molecular genetics and metabolism, 85 ((3)): (190-195). [PMID:15979030] |
| 11. Todd Thornburg,Aubrey R Turner,Yong Q Chen,Mara Vitolins,Baoli Chang,Jianfeng Xu. (2006-03-28) Phytanic acid, AMACR and prostate cancer risk.. Future oncology (London, England), 2 ((2)): (213-223). [PMID:16563090] |
| 12. A S Wierzbicki. (2007-10-25) Peroxisomal disorders affecting phytanic acid alpha-oxidation: a review.. Biochemical Society transactions, 35 ((Pt 5)): (881-886). [PMID:17956237] |
| 13. Paul P Van Veldhoven. (2010-06-19) Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism.. Journal of lipid research, 51 ((10)): (2863-2895). [PMID:20558530] |
| 14. Guilhian Leipnitz,Alexandre U Amaral,Angela Zanatta,Bianca Seminotti,Carolina G Fernandes,Lisiane A Knebel,Carmen R Vargas,Moacir Wajner. (2010-07-14) Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats.. Life sciences, 87 ((9-10)): (275-280). [PMID:20619275] |
| 15. Estela Natacha Brandt Busanello,Carolina Maso Viegas,Alana Pimentel Moura,Anelise Miotti Tonin,Mateus Grings,Carmen R Vargas,Moacir Wajner. (2010-07-14) In vitro evidence that phytanic acid compromises Na(+),K(+)-ATPase activity and the electron flow through the respiratory chain in brain cortex from young rats.. Brain research, 1352 (231-238). [PMID:20624373] |
| 16. Louise B Werner,Lars I Hellgren,Marianne Raff,Søren K Jensen,Rikke A Petersen,Tue Drachmann,Tine Tholstrup. (2011-06-15) Effect of dairy fat on plasma phytanic acid in healthy volunteers - a randomized controlled study.. Lipids in health and disease, 10 (95-95). [PMID:21663648] |
| 17. Wagner L Araújo,Kimitsune Ishizaki,Adriano Nunes-Nesi,Takayuki Tohge,Tony R Larson,Ina Krahnert,Ilse Balbo,Sandra Witt,Peter Dörmann,Ian A Graham,Christopher J Leaver,Alisdair R Fernie. (2011-07-27) Analysis of a range of catabolic mutants provides evidence that phytanoyl-coenzyme A does not act as a substrate of the electron-transfer flavoprotein/electron-transfer flavoprotein:ubiquinone oxidoreductase complex in Arabidopsis during dark-induced senescence.. Plant physiology, 157 ((1)): (55-69). [PMID:21788362] |
| 18. Alfried Kohlschütter,René Santer,Zoltan Lukacs,Christiane Altenburg,Markus J Kemper,Klaus Rüther. (2011-12-14) A child with night blindness: preventing serious symptoms of Refsum disease.. Journal of child neurology, 27 ((5)): (654-656). [PMID:22156782] |
| 19. J Liska,D Macejova,S Ondkova,J Brtko. (2012-02-15) Morphology of 1-methyl-1-nitrosourea induced rat mammary tumours after treatment with precursor of phytanic acid or its combination with vitamin D analogue.. Endocrine regulations, 46 ((1)): (21-26). [PMID:22329818] |
| 20. Nicholas J Ollberding,Briseis Aschebrook-Kilfoy,Donne Bennett D Caces,Margaret E Wright,Dennis D Weisenburger,Sonali M Smith,Brian C-H Chiu. (2012-10-09) Phytanic acid and the risk of non-Hodgkin lymphoma.. Carcinogenesis, 34 ((1)): (170-175). [PMID:23042099] |
| 21. Hugh J McMillan,Thea Worthylake,Jeremy Schwartzentruber,Chloe C Gottlieb,Sarah E Lawrence,Alex Mackenzie,Chandree L Beaulieu,Petra A W Mooyer,Ronald J A Wanders,Jacek Majewski,Dennis E Bulman,Michael T Geraghty,Sacha Ferdinandusse,Kym M Boycott. (2012-11-28) Specific combination of compound heterozygous mutations in 17β-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency.. Orphanet journal of rare diseases, 7 (90-90). [PMID:23181892] |
| 22. Mohamed M Elmazar,Hanan S El-Abhar,Mona F Schaalan,Nahla A Farag. (2013-01-10) Phytol/Phytanic acid and insulin resistance: potential role of phytanic acid proven by docking simulation and modulation of biochemical alterations.. PloS one, 8 ((1)): (e45638-e45638). [PMID:23300941] |
| 23. Ann B Moser,Jody Hey,Patricia K Dranchak,Mazen W Karaman,Junsong Zhao,Laura A Cox,Oliver A Ryder,Joseph G Hacia. (2013-02-06) Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells.. Lipids in health and disease, 12 (10-10). [PMID:23379307] |
| 24. Tõnu Püssa. (2013-05-11) Toxicological issues associated with production and processing of meat.. Meat science, 95 ((4)): (844-853). [PMID:23660174] |
| 25. Gregory G Martin,Avery L McIntosh,Huan Huang,Shipra Gupta,Barbara P Atshaves,Kerstin K Landrock,Danilo Landrock,Ann B Kier,Friedhelm Schroeder. (2013-12-05) The human liver fatty acid binding protein T94A variant alters the structure, stability, and interaction with fibrates.. Biochemistry, 52 ((51)): (9347-9357). [PMID:24299557] |
| 26. Kaoru Nagai. (2015-01-27) Phytanic acid induces Neuro2a cell death via histone deacetylase activation and mitochondrial dysfunction.. Neurotoxicology and teratology, 48 (33-39). [PMID:25619426] |
| 27. Chieko Iwao,Yoshihiro Shidoji. (2015-07-18) Polyunsaturated Branched-Chain Fatty Acid Geranylgeranoic Acid Induces Unfolded Protein Response in Human Hepatoma Cells.. PloS one, 10 ((7)): (e0132761-e0132761). [PMID:26186544] |
| 28. Hazel M Girvan,Harshwardhan Poddar,Kirsty J McLean,David R Nelson,Katherine A Hollywood,Colin W Levy,David Leys,Andrew W Munro. (2018-08-18) Structural and catalytic properties of the peroxygenase P450 enzyme CYP152K6 from Bacillus methanolicus.. Journal of inorganic biochemistry, 188 (18-28). [PMID:30119014] |
| 29. Leonard Blum,Nadja Tafferner,Ilknur Spring,Jennifer Kurz,Natasja deBruin,Gerd Geisslinger,Michael J Parnham,Susanne Schiffmann. (2018-08-29) Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression.. Journal of molecular medicine (Berlin, Germany), 96 ((10)): (1131-1144). [PMID:30151738] |
| 30. Hanning Wang,Xueying Mao,Min Du. (2019-04-06) Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes.. The Journal of nutritional biochemistry, 67 (201-211). [PMID:30951974] |
| 31. Wojciech Krężel,Ralph Rühl,Angel R de Lera. (2019-04-27) Alternative retinoid X receptor (RXR) ligands.. Molecular and cellular endocrinology, 491 (110436-110436). [PMID:31026478] |
| 32. Dong-Hee Kang,Fiona Louis,Hao Liu,Hiroshi Shimoda,Yasutaka Nishiyama,Hajime Nozawa,Makoto Kakitani,Daisuke Takagi,Daijiro Kasa,Eiji Nagamori,Shinji Irie,Shiro Kitano,Michiya Matsusaki. (2021-08-26) Engineered whole cut meat-like tissue by the assembly of cell fibers using tendon-gel integrated bioprinting.. Nature communications, 12 ((1)): (5059-5059). [PMID:34429413] |
| 33. P P Van Veldhoven,G P Mannaerts,M Casteels,K Croes. (2000-03-10) Hepatic alpha-oxidation of phytanic acid. A revised pathway.. Advances in experimental medicine and biology, 466 (273-281). [PMID:10709654] |
| 34. Sinan Cakirer,Mahmut R Savas. (2004-10-14) Infantile Refsum disease: serial evaluation with MRI.. Pediatric radiology, 35 ((2)): (212-215). [PMID:15480616] |
| 35. Jianfeng Xu,Todd Thornburg,Aubrey R Turner,Mara Vitolins,Doug Case,John Shadle,Lisa Hinson,Jielin Sun,Wennuan Liu,Baoli Chang,Tamara S Adams,S Lilly Zheng,Frank M Torti. (2005-02-16) Serum levels of phytanic acid are associated with prostate cancer risk.. The Prostate, 63 ((3)): (209-214). [PMID:15712232] |
| 36. D M van den Brink,R J A Wanders. (2006-06-27) Phytanic acid: production from phytol, its breakdown and role in human disease.. Cellular and molecular life sciences : CMLS, 63 ((15)): (1752-1765). [PMID:16799769] |
| 37. Eleanor J Baldwin,F Brian Gibberd,Claire Harley,Margaret C Sidey,Michael D Feher,Anthony S Wierzbicki. (2010-06-16) The effectiveness of long-term dietary therapy in the treatment of adult Refsum disease.. Journal of neurology, neurosurgery, and psychiatry, 81 ((9)): (954-957). [PMID:20547622] |
| 38. Nicol Kruska,Georg Reiser. (2011-05-17) Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40.. Neurobiology of disease, 43 ((2)): (465-472). [PMID:21570468] |
| 39. Wafaa Ghoneim,Hala T El-Bassyouni,Soheir A Abdel Maksoud. (2011-09-06) Peroxisomal biogenesis disorder biomarkers.. Clinical laboratory, 57 ((7-8)): (469-480). [PMID:21888010] |
| 40. Emily Waltz. (2012-03-09) Tiptoeing around transgenics.. Nature biotechnology, 30 ((3)): (215-217). [PMID:22398610] |
| 41. Shigeo Takashima,Kayoko Toyoshi,Takahiro Itoh,Naomi Kajiwara,Ayako Honda,Akiko Ohba,Shoko Takemoto,Satoshi Yoshida,Nobuyuki Shimozawa. (2017-01-17) Detection of unusual very-long-chain fatty acid and ether lipid derivatives in the fibroblasts and plasma of patients with peroxisomal diseases using liquid chromatography-mass spectrometry.. Molecular genetics and metabolism, 120 ((3)): (255-268). [PMID:28089346] |
| 42. Jiyan Li, Guoyu Xing, Min Qiao, Silu Du, Tao Zhou, Shuo Gao, Hanxue Sun, Rui Jiao, An Li. (2024) Composite porous 3D foam for solar-driven atmospheric water harvesting in low humidity natural environment. CHEMICAL ENGINEERING JOURNAL, 490 (151543). [10.1016/j.cej.2024.151543] |
| 43. Yingting Yin, Wei Li, Mao Feng, Xiaodong Hu, Jiarong Niu, Jinbo Yao. (2025) Fabrication of Flame-Retardant and Anti-dripping Waterborne Polyurethane Containing Phosphorus/Silicon via a Green and Feasible Strategy. ACS Sustainable Chemistry & Engineering, 13 (9): (3522-3533). [10.1021/acssuschemeng.4c09232] |