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丙酰-L-肉碱

COA COA
    级别和纯度:
  • ≥94%(HPLC)
有货

库存信息

关闭

库存信息

关闭

库存信息

关闭

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
P463318-5mg
 5mg 现货 Stock Image
P463318-10mg
 10mg 现货 Stock Image
P463318-25mg
 25mg 现货 Stock Image
P463318-50mg
 50mg 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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代谢物 (8911)
main product photo

基本描述

别名 (2 R )-3-羧基- N 、 N 、 N -三甲基-2-(1-氧代丙氧基)-1-丙胺 内盐 | L -肉碱丙酰基酯 | C3-肉碱
英文别名 (S)-Ethyl2-azido-2-phenylethanoate | Q27104808 | DTXSID40173883 | Levocarnitine propil | Propionitrile, 3-((.alpha.-methylphenethyl)amino)-, (.+/-.)- | AKOS015961524 | (3R)-3-(propionyloxy)-4-(trimethylammonio)butanoate | LEVOCARNITINE PROPIONATE [MART.]
规格或纯度 ≥94%(HPLC)
英文名称 Propionyl-L-carnitine
生化机理 L-丙酰肉碱(PLC)在脂质和糖类代谢中起重要作用。它为缺血性肌肉提供能量生产和ATP合成底物。丙酰肉碱可用于治疗严重的外周动脉疾病和慢性心力衰竭。丙酰肉碱与甲基丙二酸在甲基丙二酸单酰辅酶A变位酶(MUT)缺乏患者的尿中均以高丰度存在。MUT是一种线粒体酶，催化甲基丙二酰辅酶A异构化为琥珀酰辅酶A。
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

L-丙酰肉碱(PLC)是肉碱的短链脂肪酸酯衍生物。


用途
L-丙酰肉碱已用作液相色谱串联质谱(LC-MS/MS)的标准品。
纯度 ≥94%(HPLC)

关联靶点（人）

CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

lef Anthrax lethal factor (7585 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504757748
分子类型 小分子
IIUPAC Name (3R)-3-propanoyloxy-4-(trimethylazaniumyl)butanoate
INCHI InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1
InChi Key UFAHZIUFPNSHSL-MRVPVSSYSA-N
Smiles CCC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
Isomeric SMILES CCC(=O)O[C@H](CC(=O)[O-])C[N+](C)(C)C
PubChem CID 188824
分子量 217.26

化学和物理性质

比旋光度 -23±3°
闪点(℉) Not applicable
闪点(℃) Not applicable
分子量 217.260 g/mol
XLogP3 0.900
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 4
可旋转键计数Rotatable Bond Count 6
精确质量Exact Mass 217.131 Da
单同位素质量Monoisotopic Mass 217.131 Da
拓扑极表面积Topological Polar Surface Area 66.400 Ų
重原子数Heavy Atom Count 15
形式电荷Formal Charge 0
复杂度Complexity 227.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 1
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

RIDADR NONH for all modes of transport

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到11个结果

批号(Lot Number) 证书类型 货号
I2528418 分析证书 P463318
I2528419 分析证书 P463318
I2528420 分析证书 P463318
G2301132 分析证书 P463318
G2301134 分析证书 P463318
G2301136 分析证书 P463318
G2301137 分析证书 P463318
G2301138 分析证书 P463318
G2301140 分析证书 P463318
G2301141 分析证书 P463318
G2301145 分析证书 P463318

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引用文献

1. M J Cipolla,A Nicoloff,T Rebello,A Amato,J M Porter.  (1999-06-09)  Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism..  Journal of vascular surgery,  29  ((6)): (1097-1103).  [PMID:10359944]
2. Judit Bene,Katalin Komlósi,Beáta Gasztonyi,Márk Juhász,Zsolt Tulassay,Béla Melegh.  (2006-01-21)  Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet..  World journal of gastroenterology,  11  ((42)): (6671-6675).  [PMID:16425363]
3. William R Hiatt,Mark A Creager,Antonino Amato,Eric P Brass.  (2010-09-24)  Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease..  Journal of cardiopulmonary rehabilitation and prevention,  31  ((2)): (125-132).  [PMID:20861750]
4. Carmen Mingorance,Rosalia Rodriguez-Rodriguez,Maria Luisa Justo,Maria Dolores Herrera,Maria Alvarez de Sotomayor.  (2011-04-28)  Pharmacological effects and clinical applications of propionyl-L-carnitine..  Nutrition reviews,  69  ((5)): (279-290).  [PMID:21521230]
5. Robert A Koeth,Zeneng Wang,Bruce S Levison,Jennifer A Buffa,Elin Org,Brendan T Sheehy,Earl B Britt,Xiaoming Fu,Yuping Wu,Lin Li,Jonathan D Smith,Joseph A DiDonato,Jun Chen,Hongzhe Li,Gary D Wu,James D Lewis,Manya Warrier,J Mark Brown,Ronald M Krauss,W H Wilson Tang,Frederic D Bushman,Aldons J Lusis,Stanley L Hazen.  (2013-04-09)  Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis..  Nature medicine,  19  ((5)): (576-585).  [PMID:23563705]
6. Minzhi Peng,Xiefan Fang,Yonglan Huang,Yanna Cai,Cuili Liang,Ruizhu Lin,Li Liu.  (2013-10-31)  Separation and identification of underivatized plasma acylcarnitine isomers using liquid chromatography-tandem mass spectrometry for the differential diagnosis of organic acidemias and fatty acid oxidation defects..  Journal of chromatography. A,  1319  (97-106).  [PMID:24169039]
7. Josiane Joseph,Dong Seong Cho,Jason D Doles.  (2018-10-05)  Metabolomic Analyses Reveal Extensive Progenitor Cell Deficiencies in a Mouse Model of Duchenne Muscular Dystrophy..  Metabolites,  8  ((4)): [PMID:30282911]
8. Evan L Pannkuk,Evagelia C Laiakis,Kirandeep Gill,Shreyans K Jain,Khyati Y Mehta,Denise Nishita,Kim Bujold,James Bakke,Janet Gahagen,Simon Authier,Polly Chang,Albert J Fornace.  (2019-03-08)  Liquid Chromatography-Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels..  Journal of proteome research,  18  ((5)): (2260-2269).  [PMID:30843397]
9. Ralph Fingerhut,Regina Ensenauer,Wulf Röschinger,Ralf Arnecke,Bernhard Olgemöller,Adelbert A Roscher.  (2009-03-28)  Stability of acylcarnitines and free carnitine in dried blood samples: implications for retrospective diagnosis of inborn errors of metabolism and neonatal screening for carnitine transporter deficiency..  Analytical chemistry,  81  ((9)): (3571-3575).  [PMID:19323528]
10. Santica M Marcovina,Cesare Sirtori,Andrea Peracino,Mihai Gheorghiade,Peggy Borum,Giuseppe Remuzzi,Hossein Ardehali.  (2012-11-10)  Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine..  Translational research : the journal of laboratory and clinical medicine,  161  ((2)): (73-84).  [PMID:23138103]
11. Qixiao Jiang,Chunbo Wang,Chan Xue,Lingfang Xue,Meiting Wang,Changhao Li,Ziwen Deng,Qian Wang.  (2016-10-25)  Changes in the levels of l-carnitine, acetyl-l-carnitine and propionyl-l-carnitine are involved in perfluorooctanoic acid induced developmental cardiotoxicity in chicken embryo..  Environmental toxicology and pharmacology,  48  (116-124).  [PMID:27771504]

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