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聚N-异丙基丙烯酰胺

10篇引用文献 COA COA
    级别和纯度:
  • Mw(Viscosity-average) 300000
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货号 (SKU) 包装规格 是否现货 价格 数量
P432408-100mg
 100mg 现货 Stock Image
P432408-250mg
 250mg 现货 Stock Image
P432408-1g
 1g 现货 Stock Image
P432408-5g
 5g 现货 Stock Image
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聚合物 (130)
main product photo

基本描述

别名 聚丙烯酰胺, 聚(N-异丙基丙烯酰胺), PNIPAM, NIPAM 聚合物
英文别名 AS-18956 | Isopropyl acrylamide | 2-Propenamide, N-(1-methylethyl)- | N-ISOPROPYLACRYLAMIDE [HSDB] | n-isopropylpropenamide | NSC11448 | NSC-11448 | ISOPROPYLACRYLAMIDE [INCI] | N-Isopropylacrylamide, >=99% | D70366 | FT-0700646 | N-Isopropylacrylamide, 9
规格或纯度 Mw(Viscosity-average) 300000
英文名称 Poly(N-isopropylacrylamide)
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍


General Description

Poly( N -isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer used in biomedical research applications. PNIPAM undergoes a reversible, lower critical solution temperature (LCST) phase transition when heated above 32 °C, transitioning from a soluble to an insoluble material. PNIPAM is also frequently crosslinked to yield hydrogels with reversible, thermal shrinking and swelling. Poly( N -isopropylacrylamide) is also readily functionalized and has been used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. Due to the similarity in temperature between the LCST of PNIPAM and the temperature of the human body, PNIPAM materials have been frequently utilized in tissue engineering and controlled drug delivery research applications. Poly( N -isopropylacrylamide) (PNIPAM) is a thermo-sensitive polymer with a low critical solution temperature (LCST). It exhibits both hydrophobic and hydrophilic characteristics below and above the LCST. It forms microgels, typically by free-radical precipitation polymerization.


Application

PNIPAM can be used in the formation of a smart hydrogel, which finds potential usage in sensors, fuel cells, supercapacitors, and lithium-ion batteries. It can also be used in the fabrication of molecular nanothermometer. PNIPAM is coated with gold nanoparticles (AuNPs) to form microgels that facilitate highly reproducible signals for surface-enhanced Raman scattering (SERS). Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.

关联靶点（人）

TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 未知
IIUPAC Name N-propan-2-ylprop-2-enamide
INCHI 1S/C6H11NO/c1-4-6(8)7-5(2)3/h4-5H,1H2,2-3H3,(H,7,8)
InChi Key QNILTEGFHQSKFF-UHFFFAOYSA-N
Smiles CC(C)NC(=O)C=C
Isomeric SMILES CC(C)NC(=O)C=C
Reaxy-Rn 1744926
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1744926&ln=

化学和物理性质

溶解性 Soluble in Acetone, THF, water (cold)
密度 1.10
分子量 113.160 g/mol
XLogP3 0.900
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 1
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 113.084 Da
单同位素质量Monoisotopic Mass 113.084 Da
拓扑极表面积Topological Polar Surface Area 29.100 Ų
重原子数Heavy Atom Count 8
形式电荷Formal Charge 0
复杂度Complexity 96.700
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H302: 吞食有害

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P330: 漱口

P337: 如果眼睛刺激持续存在：求医/就诊。

P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。

P302+P352: 如皮肤沾染：用水充分清洗。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P501: 将内容物/容器处理到。。。

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批号(Lot Number) 证书类型 货号
E2515583 分析证书 P432408
E2515608 分析证书 P432408
E2520701 分析证书 P432408
H2321146 分析证书 P432408
H2321147 分析证书 P432408
H2321148 分析证书 P432408
H2321183 分析证书 P432408
H2321184 分析证书 P432408
H2321185 分析证书 P432408
H2321422 分析证书 P432408
H2321423 分析证书 P432408

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此产品的引用文献

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引用文献

1. Antti Rahikkala,Vladimir Aseyev,Heikki Tenhu,Esko I Kauppinen,Janne Raula.  (2015-07-25)  Thermoresponsive Nanoparticles of Self-Assembled Block Copolymers as Potential Carriers for Drug Delivery and Diagnostics..  Biomacromolecules,  16  ((9)): (2750-2756).  [PMID:26207325]
2. Min Seon Heo,Eun Jin Seo,Johnson V John,Il Ho Jang,Jae Ho Kim,Il Kim.  (2016-03-24)  Synthesis of hyperbranched polyglycidol-b-poly(N-isopropylacrylamide) using nitroxide-mediated polymerization for thermo-sensitive drug delivery system..  Journal of controlled release : official journal of the Controlled Release Society,  213  (e80-e80).  [PMID:27005234]
3. S Panja,G Dey,R Bharti,K Kumari,T K Maiti,M Mandal,S Chattopadhyay.  (2016-04-30)  Tailor-Made Temperature-Sensitive Micelle for Targeted and On-Demand Release of Anticancer Drugs..  ACS applied materials & interfaces,  8  ((19)): (12063-12074).  [PMID:27128684]
4. Muhammad Abdul Haq,Yunlan Su,Dujin Wang.  (2016-10-25)  Mechanical properties of PNIPAM based hydrogels: A review..  Materials science & engineering. C, Materials for biological applications,  70  ((Pt 1)): (842-855).  [PMID:27770962]
5. Qian Pang, Kaihao Wu, Zilian Jiang, Fang Yang, Zewen Shi, Hanlin Gao, Cuicui Zhang, Ruixia Hou, Yabin Zhu.  (2023)  Nanostructured ionic hydrogel with integrated conductivity, stretchability and thermal responsiveness for a high-performance strain and temperature sensor.  Biomaterials Science,  11  (10): (3603-3615).  [PMID:37009640] [10.1039/D3BM00074E]
6. Yingying Cao, Yaofeng Wang, Bingtong Chen, Yiwei Zhu, Hui Wang.  (2023)  Design of Dual Stimuli-Responsive Copolymerized Ionic Liquid with Flexible Phase Transition Temperature and Its Application in Selective Separation of Artemisitene/Artemisinin.  ACS Sustainable Chemistry & Engineering,  11  (11): (4463–4472).  [10.1021/acssuschemeng.2c07648]
7. Yang Han, Yangsai Lyu, Ningning Xing, Xiaolei Zhang, Kaiyuan Hu, Hui Luo, Dickon H. L. Ng, Jia Li.  (2022)  Ion-imprinted MnO2/CoFe2O4 Janus magnetic micromotors synthesized by a lotus pollen template for highly selective recognition and capture of Pb(II) ions.  Journal of Materials Chemistry C,  10  (41): (15524-15531).  [10.1039/D2TC02458F]
8. Jian Li, Jinsheng Sun, Kaihe Lv, Yuxi Ji, Jintao Ji, Jingping Liu.  (2022)  Nano-Modified Polymer Gels as Temperature- and Salt-Resistant Fluid-Loss Additive for Water-Based Drilling Fluids.  Gels,  8  (9): (547).  [PMID:36135259] [10.3390/gels8090547]
9. Qian Pang, Hongtao Hu, Haiqi Zhang, Bianbian Qiao, Lie Ma.  (2022)  Temperature-Responsive Ionic Conductive Hydrogel for Strain and Temperature Sensors.  ACS Applied Materials & Interfaces,  14  (23): (26536–26547).  [PMID:35657037] [10.1021/acsami.2c06952]
10. Shaoping Ma, Fenfang Li, Zhijian Tan.  (2022)  Recyclable aqueous two-phase system formed by two temperature-responsive polymers for the chiral resolution of mandelic acid enantiomers.  JOURNAL OF MOLECULAR LIQUIDS,  352  (118738).  [10.1016/j.molliq.2022.118738]
11. Ying Xiao, Zhao-Yang Wang, Shi-He Luo, Jian-Yun Lin, Xi-Ying Cao, Yong-Gan Fang.  (2021)  One-pot preparation of thermosensitive polylactic acid materials by modifying with N-Isopropyl acrylamide.  POLYMER,  231  (124126).  [10.1016/j.polymer.2021.124126]
12. Zheng Hang, Li Jin, Song Weizheng, He Guangyao, Wang Yifeng, Chen Yanjun.  (2021)  Thermal-responsive Photonic Crystals based on Physically Cross-linked Inverse Opal Nanocomposite Hydrogels.  JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION,  36  (2): (289-296).  [10.1007/s11595-021-2408-8]
13. Ge Wang, Peiyi Wu.  (2016)  Unusual Phase Transition Behavior of Poly(N-isopropylacrylamide)-co-Poly(tetrabutylphosphonium styrenesulfonate) in Water: Mild and Linear Changes in the Poly(N-isopropylacrylamide) Part.  LANGMUIR,  32  (15): (3728–3736).  [PMID:27022971] [10.1021/acs.langmuir.6b00392]
14. Song Zhang, Mengjia Fang, Junjun He, Lina Ma, Xiaohe Miao, Peichuang Li, Shirui Yu, Wanhao Cai.  (2024)  How specific ion effects influence the mechanical behaviors of amide macromolecules? A cross-scale study.  RSC Advances,  14  (35): (25507-25515).  [PMID:39139238] [10.1039/D4RA04360J]

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