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6篇引用文献 
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库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P426110-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | 红紫素 | 1,2,4-三羟基蒽醌 | 羟基氮杂酸 |
|---|---|
| 英文别名 | 4,9,10-trihydroxy-1,2-anthraquinone | 1,2,4-Trihydroxyanthra-9,10-quinone | Hydroxylizaric acid | KBio3_002835 | P0605 | 1,2,4-trihydroxyanthracene-9,10-dione | 9TF | Oxylizarinic acid | HY-N0571 | Spectrum2_000037 | STK396669 | L1GT81LS6N | AKOS001482720 |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Purpurin |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Purpurin is a xanthine oxidase inhibitor that reduces the formation of azoxymethane-induced aberrant crypt foci in rat colon studies. Purpurin is a xanthine oxidase inhibitor that reduces the formation of azoxymethane-induced aberrant crypt foci in rat colon studies. |
关联靶点（人）
CYP1B1
Tchem
细胞色素 P450 1B1(Cytochrome P450 1B1)
(1 活性数据)
MAOA
Tclin
胺氧化酶[含黄素]A(Amine oxidase [flavin-containing] A)
(1 活性数据)
VDR
Tclin
Vitamin D receptor
(26531 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
MAOB
Tclin
Monoamine oxidase B
(8835 活性数据)
CYP1B1
Tchem
Cytochrome P450 1B1
(1148 活性数据)
PLK1
Tchem
Serine/threonine-protein kinase PLK1
(28605 活性数据)
CYP1A1
Tchem
Cytochrome P450 1A1
(1169 活性数据)
ALDH1A1
Tchem
Aldehyde dehydrogenase 1A1
(77053 活性数据)
ALOX12
Tchem
Arachidonate 12-lipoxygenase
(3262 活性数据)
MMP14
Tchem
Matrix metalloproteinase 14
(1592 活性数据)
ALOX15
Tchem
Arachidonate 15-lipoxygenase
(7108 活性数据)
PIN1
Tchem
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
(36611 活性数据)
CYP3A4
Tclin
Cytochrome P450 3A4
(53859 活性数据)
A498
(42825 活性数据)
ACHN
(49357 活性数据)
CAKI-1
(44928 活性数据)
CCRF-CEM
(65223 活性数据)
COLO 205
(50209 活性数据)
DLD-1
(17511 活性数据)
DMS-273
(14108 活性数据)
HL-60
(67320 活性数据)
K562
(73714 活性数据)
KM12
(47707 活性数据)
M14
(47487 活性数据)
MOLT-4
(49676 活性数据)
OVCAR-3
(48710 活性数据)
OVCAR-4
(44535 活性数据)
OVCAR-5
(45555 活性数据)
OVCAR-8
(47708 活性数据)
Raji
(5516 活性数据)
RPMI-8226
(44974 活性数据)
RXF 393
(41971 活性数据)
RXF 631
(11415 活性数据)
SF-295
(48000 活性数据)
SK-MEL-2
(46422 活性数据)
SK-MEL-28
(48833 活性数据)
SK-MEL-5
(47095 活性数据)
SK-OV-3
(52876 活性数据)
SN12C
(47755 活性数据)
SNB-19
(46794 活性数据)
SNB-78
(14240 活性数据)
TK-10
(45540 活性数据)
U-251
(51189 活性数据)
UACC-257
(46019 活性数据)
UACC-62
(47335 活性数据)
UO-31
(46270 活性数据)
XF498
(12972 活性数据)
786-0
(47912 活性数据)
A549
(127892 活性数据)
EKVX
(44102 活性数据)
NCI-H322M
(45589 活性数据)
关联靶点（其它种属）
Ttr
Transthyretin (14 活性数据)
Cruzipain (33337 活性数据)
Mapk1
MAP kinase ERK2 (650 活性数据)
ftsZ
Cell division protein ftsZ (97 活性数据)
Escherichia coli (133304 活性数据)
Bacillus subtilis (32866 活性数据)
Plasmodium falciparum (966862 活性数据)
GCN5
Histone acetyltransferase GCN5 (89 活性数据)
fadD28
Acyl-CoA synthase (418 活性数据)
Mapt
Microtubule-associated protein tau (6 活性数据)
fba
Putative fructose-1,6-bisphosphate aldolase (15559 活性数据)
Impa1
Inositol monophosphatase 1 (16203 活性数据)
rev
Protein Rev (94 活性数据)
gld-1
Female germline-specific tumor suppressor gld-1 (77 活性数据)
Phosphoglycerate kinase, glycosomal (2184 活性数据)
TUBB2B
Tubulin (2175 活性数据)
vpr
Aberrant vpr protein (14595 活性数据)
groL
GroEL/GroES (1042 活性数据)
groEL
60 kDa chaperonin (64 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 1,2,4-trihydroxyanthracene-9,10-dione |
| INCHI | 1S/C14H8O5/c15-8-5-9(16)14(19)11-10(8)12(17)6-3-1-2-4-7(6)13(11)18/h1-5,15-16,19H |
| InChi Key | BBNQQADTFFCFGB-UHFFFAOYSA-N |
| Smiles | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3O)O)O |
| Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C(=C(C=C3O)O)O |
| PubChem CID | 6683 |
| 分子量 | 256.21 |
| Beilstein号 | 8509 |
| Reaxy-Rn | 1887127 |
化学和物理性质
| 熔点 | 253-256 °C |
|---|---|
| 分子量 | 256.209 g/mol |
| XLogP3 | 2.900 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 256.037 Da |
| 单同位素质量Monoisotopic Mass | 256.037 Da |
| 拓扑极表面积Topological Polar Surface Area | 94.800 Ų |
| 重原子数Heavy Atom Count | 19 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 407.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| RTECS | CB8200000 |
| Merck Index | 7945 |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Xu Liu, Xiao Han, Yushuang Shang, Lijuan Wang, Jian Shen, Jiang Yuan. (2023) Hydrogen sulfide releasing poly(γ-glutamic acid) biocomposite hydrogel with monitoring, antioxidant, and antibacterial properties for diabetic wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 253 (127053). [PMID:37774813] [10.1016/j.ijbiomac.2023.127053] |
| 2. Ming Guan, Xiaojing Kang, Le Wei, Xingjun Hu, Chao Han, Xing Li, Hanwen Liu, Liang Qu, Zhenwen Zhao. (2022) A dual-mode strategy combining SERS with MALDI FTICR MS based on core-shell silver nanoparticles for dye identification and semi-quantification in unearthed silks from Tang Dynasty. TALANTA, 241 (123277). [PMID:35121543] [10.1016/j.talanta.2022.123277] |
| 3. Wen Wang, Jiaxing Zhang, Wei Qi, Rongxin Su, Zhimin He, Xin Peng. (2021) Alizarin and Purpurin from Rubia tinctorum L. Suppress Insulin Fibrillation and Reduce the Amyloid-Induced Cytotoxicity. ACS Chemical Neuroscience, 12 (12): (2182–2193). [PMID:34033711] [10.1021/acschemneuro.1c00177] |
| 4. Wei Ji, Wenmei Ao, Mengqiu Sun, Chunlai Feng, Yun Wang. (2021) Separation and purification of horseradish peroxidase from horseradish roots using a novel integrated method. NEW JOURNAL OF CHEMISTRY, 45 (4): (1959-1966). [10.1039/D0NJ04614K] |
| 5. Wei Zhang, Peipei Zhou, Wei Liu, Huili Wang, Xuedong Wang. (2020) Enhanced adsorption/extraction of five typical polycyclic aromatic hydrocarbons from meat samples using magnetic effervescent tablets composed of dicationic ionic liquids and NiFe2O4 nanoparticles. JOURNAL OF MOLECULAR LIQUIDS, 315 (113682). [10.1016/j.molliq.2020.113682] |
| 6. Jing Li, Qingxiang Zhou, Yongli Liu, Man Lei. (2017) Recyclable nanoscale zero-valent iron-based magnetic polydopamine coated nanomaterials for the adsorption and removal of phenanthrene and anthracene. SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, [PMID:28179954] [10.1080/14686996.2016.1246941] |