| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P424639-1ml |
1ml |
现货  |
|
| 英文别名 | HMS1791I16 | HMS2234L19 | LMFA08040013 | Monoethanolamine palmitic acid amide | Bio1_001307 | PALMITAMIDE MEA [INCI] | Bio2_000174 | N-(2-Hydroxyethyl)hexadecanamide | s4708 | Impulsin | Palmitamide MEA | hexadecanoyl ethanolamide | Levagen | N-(2-hydroxy |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Palmitoylethanolamide |
| 生化机理 | 内源性 CB2 大麻受体激动剂。内源性脂质是一种强效、选择性 GPR55 激动剂（EC 50 = 4 nM）。对 CB 2 和 CB 1 受体具有高度选择性（EC 50 值分别为 19.8 和 >30 μM）。脂肪酸酰胺水解酶 (FAAH) 和 PEA 首选酸酰胺酶 (PAA) 亚基 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | GPR119 激动剂;GPR55 激动剂 |
| 产品介绍 |
Palmitoylethanolamide is an endogenous cannabinoid. It is a weak ligand of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors. It has been found to inhibit FAAH (fatty acid amide hydrolase). Palmitoylethanolamide exhibits anti-nociceptive, anti-inflammatory, anti-convulsant and immunosuppresant activity. Palmitoylethanolamide acts by binding to an unidentified cannabinoid receptor that is similar to CB2. It also acts as a selective activator of the GPR55 receptor. In addition, this compound directly activates PPARα, producing an anti-inflammatory response. Palmitoylethanolamide is an endogenous cannabinoid. It is a weak ligand of the cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptors. It has been found to inhibit FAAH (fatty acid amide hydrolase). Palmitoylethanolamide exhibits anti-nociceptive, anti-inflammatory, anti-convulsant and immunosuppresant activity. Palmitoylethanolamide acts by binding to an unidentified cannabinoid receptor that is similar to CB2. It also acts as a selective activator of the GPR55 receptor. In addition, this compound directly activates PPARα, producing an anti-inflammatory response. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | N-(2-hydroxyethyl)hexadecanamide |
| INCHI | 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)19-16-17-20/h20H,2-17H2,1H3,(H,19,21) |
| InChi Key | HXYVTAGFYLMHSO-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCCCCCC(=O)NCCO |
| Isomeric SMILES | CCCCCCCCCCCCCCCC(=O)NCCO |
| 分子量 | 299.492 |
| Reaxy-Rn | 1789716 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1789716&ln= |
| 敏感性 | 对热敏感 |
|---|---|
| 熔点 | 99 °C |
| 分子量 | 299.500 g/mol |
| XLogP3 | 6.200 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 16 |
| 精确质量Exact Mass | 299.282 Da |
| 单同位素质量Monoisotopic Mass | 299.282 Da |
| 拓扑极表面积Topological Polar Surface Area | 49.300 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 219.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS05, GHS07, GHS09 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H315: 引起皮肤刺激 H318: 造成严重的眼睛损伤 H411: 对水生生物有毒并具有长期持续影响 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P391: 收集溢出物 P302+P352: 如皮肤沾染：用水充分清洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 |
| WGK Germany | 3 |
| Merck Index | 6995 |
| 个人防护装备 | Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter |
| 1. Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu, Canzhong Lu. (2022) N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation. PHARMACOLOGICAL RESEARCH, 185 (106491). [PMID:36244543] [10.1016/j.phrs.2022.106491] |
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