| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P421104-1ml |
1ml |
现货  |
|
| 别名 | 硫酸巴龙霉素 |
|---|---|
| 英文别名 | SCHEMBL3355 | EN300-245883 | PAROMOMYCIN SULFATE [USP MONOGRAPH] | A883521 | PAROMOMYCIN SULFATE (USP-RS) | Paromomycin sulfate [USP:JAN] | (1,1'-BIPHENYL-2-YL)BORONIC ACID | Humagel | Q27269495 | Aminosidine sulphate | CHEBI:7935 | NSC227228 | D-Streptam |
| 规格或纯度 | 10mM in Water |
| 英文名称 | Paromomycin Sulfate |
| 生化机理 | 广谱氨基糖苷类抗生素。蛋白质合成抑制剂。与16S核糖体RNA结合。口服具有活性 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Paromomycin (Aminosidine) sulfate 是一种的广谱氨基糖苷类抗生素 (antibiotic)，具有杀螨杀菌作用，是新霉素 (HY-B0470) 衍生物。Paromomycin sulfate 通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。Paromomycin sulfate 可用于细菌和寄生虫感染的研究。 Product Application： Paromomycin sulfate salt has been used as a reference compound in antileishmanial activity, RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex. It has also been used in cell culture applications at 100mg/L. Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric acid |
| INCHI | 1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 |
| InChi Key | LJRDOKAZOAKLDU-UDXJMMFXSA-N |
| Smiles | C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O |
| Isomeric SMILES | C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N.OS(=O)(=O)O |
| 关联CAS | 7542-37-2；84420-34-8 |
| 分子量 | 615.63 (free base basis) |
| 敏感性 | 对湿度敏感 |
|---|---|
| 比旋光度 | 48° (C=1,H2O) |
| 分子量 | 713.700 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 15 |
| 氢键受体数Hydrogen Bond Acceptor Count | 23 |
| 可旋转键计数Rotatable Bond Count | 9 |
| 精确质量Exact Mass | 713.264 Da |
| 单同位素质量Monoisotopic Mass | 713.264 Da |
| 拓扑极表面积Topological Polar Surface Area | 430.000 Ų |
| 重原子数Heavy Atom Count | 47 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 952.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 19 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| RTECS | WK2320000 |
|---|---|
| Merck Index | 7041 |
| 1. Lu Qi, Shanshan Liu, Zhen Yan, Min Qiao, Haonan Peng, Liping Ding. (2024) A cross-reactive fluorescent ensemble based on perylene derivative/surfactant assemblies for discrimination of multiple aminoglycoside antibiotics in aqueous solution. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 446 (115128). [10.1016/j.jphotochem.2023.115128] |
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