| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P408466-1ml |
1ml |
现货  |
|
| 英文别名 | Kakonein | 4H-1-Benzopyran-4-one, 8-β-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)- |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Puerarin |
| 生化机理 | 葛根素（Kakonein）是一种存在于葛根中的异黄酮，是一种 5-HT2C 受体和苯并二氮杂卓部位拮抗剂。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激活剂 |
| 作用机制 | TRPV4 激活剂 |
| 产品介绍 |
Information Puerarin Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. Puerarin (Kakonein), an isoflavones found in the root of Radix puerariae, is a 5-HT2C receptor and benzodiazepine site antagonist. Pueraria is employed clinically to treat cardiovascular diseases in China. Another study showed that puerarin also possessed anti-cancer properties. Puerarin at 25 μM dose-dependently reduces HT-29 cellular growth with an increase of bax and decreases of c-myc and bcl-2. In vivo In hypercholesterolmic diet plus administration of puerarin (300 mg/kg/day, p.o.) rats, Puerarin markedly attenuated the increased total cholesterol induced by hypercholesterolmic diet in both serum and liver. LD50: Mice 738mg/kg (i.v.) cell lines：OV2008 and SK-OV-3 cells Concentrations： Incubation Time： Powder Purity:≥99% |
| EC号 | 609-296-1 |
|---|---|
| 分子类型 | 小分子 |
| Isomeric SMILES | C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O |
| 关联CAS | 3681-99-0 |
| MeSH Entry Terms | 7,4'-dihydroxyisoflavone-8beta-glucopyranoside;kakonein;puerarin |
| 分子量 | 416.38 |
| Beilstein号 | 64198 |
| Reaxy-Rn | 1359060 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1359060&ln= |
| 熔点 | 187-189°C |
|---|
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | UO5216000 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
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| 2. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. (2024) Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 238 (106450). [PMID:38143010] [10.1016/j.jsbmb.2023.106450] |
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| 7. Jingtong Xia, Jiahao Zhou, Yanlong Liu, Na Yan, Xiaowen Hu, Lei Zhou, Qiaosheng Pu. (2023) Non-destructive distinction of single seed for Medicago sativa and Melilotus officinalis by capillary electrophoresis with laser-induced fluorescence detection. JOURNAL OF CHROMATOGRAPHY A, 1704 (464116). [PMID:37290349] [10.1016/j.chroma.2023.464116] |
| 8. Ping Huang, Shi-Xia Du. (2023) Puerarin Enhances the Anti-Tumor Effect of Cisplatin on Drug-Resistant A549 Cancer in vivo and in vitro Through Activation of the Wnt Signaling Pathway. Cancer Management and Research, [PMID:32801873] [10.2147/CMAR.S253327] |
| 9. Ruiyi Fan, Congyi Zhu, Diyang Qiu, Genlin Mao, Bernd Mueller-Roeber, Jiwu Zeng. (2023) Integrated transcriptomic and metabolomic analyses reveal key genes controlling flavonoid biosynthesis in Citrus grandis ‘Tomentosa’ fruits. PLANT PHYSIOLOGY AND BIOCHEMISTRY, 196 (210). [PMID:36724705] [10.1016/j.plaphy.2023.01.050] |
| 10. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100] [10.1016/j.crfs.2022.100424] |
| 11. Zafarullah Muhammad, Rabia Ramzan, Ruifen Zhang, Dong Zhao, Nazia Khalid, Mei Deng, Lihong Dong, Mahwash Aziz, Rizwana Batool, Mingwei Zhang. (2022) Enhanced Bioaccessibility of Microencapsulated Puerarin Delivered by Pickering Emulsions Stabilized with OSA-Modified Hydrolyzed Pueraria montana Starch: In Vitro Release, Storage Stability, and Physicochemical Properties. Foods, 11 (22): (3591). [PMID:36429183] [10.3390/foods11223591] |
| 12. Zeng Wanying, Liu Xiaojing, Wu Yangyang, Cai Yuting, Li Zhennan, Ye Fei, Sun Yuanhong, Li Feng, Xing Huijie, Wang Shuai. (2022) Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis. Frontiers in Pharmacology, 13 [PMID:36408246] [10.3389/fphar.2022.1053610] |
| 13. Yumin Liu, Ziqi Hu, Jing Wang, Yanjun Liao, Luan Shu. (2022) Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling. NUTRITIONAL NEUROSCIENCE, [PMID:36039913] [10.1080/1028415X.2022.2112439] |
| 14. Jingyi Hu, Yiheng Tong, Zhaofeng Shen, Yanan Li, Cheng Cheng, Ryan Au, Feng Xu, Yajun Liu, Lei Zhu, Hong Shen. (2022) Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-γ signaling. BIOMEDICINE & PHARMACOTHERAPY, 154 (113571). [PMID:36007273] [10.1016/j.biopha.2022.113571] |
| 15. Xiaoling Zeng, Baohui Chen, Luping Wang, Yingxiao Sun, Zhao Jin, Xuanyong Liu, Liping Ouyang, Yun Liao. (2023) Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression. Bioactive Materials, 19 (653). [PMID:35600974] [10.1016/j.bioactmat.2022.04.032] |
| 16. Yejun Zhong, Lei Yang, Taotao Dai, Ziyi Zhu, Hongyu Chen, Jianyong Wu, Er Sheng Gong. (2022) Flavonoids enhance gel strength of ovalbumin: Properties, structures, and interactions. FOOD CHEMISTRY, 387 (132892). [PMID:35405558] [10.1016/j.foodchem.2022.132892] |
| 17. Yejun Zhong, Lei Yang, Ziyi Zhu, Hongyu Chen, Chengmei Liu, Taotao Dai, Er Sheng Gong. (2022) Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase. FOOD RESEARCH INTERNATIONAL, 156 (111188). [PMID:35651046] [10.1016/j.foodres.2022.111188] |
| 18. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
| 19. Yameng Zhu, Mengmeng Zhang, Shujie Wei, Boyao Wang, Jun He, Xilong Qiu. (2022) Temperature-responsive P(NIPAM-co-NHMA)-grafted organic-inorganic hybrid hollow mesoporous silica nanoparticles for controlled drug delivery. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 70 (103197). [10.1016/j.jddst.2022.103197] |
| 20. Hao Yuan, Wan Li, Chengwu Song, Rongzeng Huang. (2022) An injectable supramolecular nanofiber-reinforced chitosan hydrogel with antibacterial and anti-inflammatory properties as potential carriers for drug delivery. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 205 (563). [PMID:35149101] [10.1016/j.ijbiomac.2022.02.015] |
| 21. Zhu Tiantian, Zhu Moli, Qiu Yue, Wu Zeqing, Huang Ning, Wan Guangrui, Xu Jian, Song Ping, Wang Shuangxi, Yin Yaling, Li Peng. (2021) Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats. Frontiers in Behavioral Neuroscience, 15 [PMID:34720898] [10.3389/fnbeh.2021.717008] |
| 22. Yang Liu, Xiaoping Zhang, Tengling Wu, Bo Liu, Jianhai Yang, Wenguang Liu. (2021) Chinese herb-crosslinked hydrogel bearing rBMSCs-laden polyzwitterion microgels: Self-adaptive manipulation of micromilieu and stemness maintenance for restoring infarcted myocardium. Nano Today, 41 (101306). [10.1016/j.nantod.2021.101306] |
| 23. Yufen Han, Yarong Lv, Jia Chen, Ming Yao, Ce Wang, Ping Hu, Yong Liu. (2021) Electrospun Core–Shell Structure Fibers for Puerarin-Loaded Vascular Grafts. ACS Applied Polymer Materials, 3 (8): (4195–4202). [10.1021/acsapm.1c00633] |
| 24. Xiangrong Li, Ruonan Xu, Zeqing Cheng, Zhizhi Song, Ziyang Wang, Hanxiao Duan, Xinzhe Wu, Tianjun Ni. (2021) Comparative study on the interaction between flavonoids with different core structures and hyaluronidase. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120079). [PMID:34175762] [10.1016/j.saa.2021.120079] |
| 25. Lan Mo, Guang-lei Zhao, Xiao-feng Li, Xing-long Xiao, Ning He, Juan-juan Ma, Yi-gang Yu. (2021) Evaluation of the digestion and transport profiles and potential immunocompetence of puerarin and its acylated derivatives. Food & Function, 12 (13): (5949-5958). [PMID:34031685] [10.1039/D1FO00555C] |
| 26. Zhou Yufeng, Duan Liguang, Huang Yixin, Liu Yaqi, Wang Lijuan, Qiao Xiaoqiang. (2021) Ionic Liquid 1-Vinyl-3-dodecylimidazole Bromide Embedded Hybrid Monolithic Column and Its Versatile Post-modification with Amino Acids. Journal of Analysis and Testing, 5 (4): (387-395). [10.1007/s41664-021-00171-2] |
| 27. Yejun Zhong, Jincheng Zhao, Taotao Dai, Jiangping Ye, Jianyong Wu, Tingting Chen, Chengmei Liu. (2021) Fabrication of Oil-in-Water Emulsions with Whey Protein Isolate–Puerarin Composites: Environmental Stability and Interfacial Behavior. Foods, 10 (4): (705). [PMID:33810424] [10.3390/foods10040705] |
| 28. Yejun Zhong, Jincheng Zhao, Taotao Dai, David Julian McClements, Chengmei Liu. (2021) The effect of whey protein-puerarin interactions on the formation and performance of protein hydrogels. FOOD HYDROCOLLOIDS, 113 (106444). [10.1016/j.foodhyd.2020.106444] |
| 29. Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen. (2021) Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling. Annals of Hepatology, 20 (100259). [PMID:32980439] [10.1016/j.aohep.2020.07.013] |
| 30. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519] |
| 31. Chunjun Wang, Jihong Yao, Linjie Ju, Xiaohua Wen, Luan Shu. (2020) Puerarin ameliorates hyperglycemia in HFD diabetic mice by promoting β-cell neogenesis via GLP-1R signaling activation. PHYTOMEDICINE, 70 (153222). [PMID:32361558] [10.1016/j.phymed.2020.153222] |
| 32. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
| 33. Haifeng Li, Shuang Wang, Fan Cui, Beibei Zhuo, Shuang Wang, Chenrui Zhao, Weilu Liu. (2020) Sensitive and selective detection of puerarin based on the hybrid of reduced graphene oxide and molecularly imprinted polymer. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 185 (113221). [PMID:32145538] [10.1016/j.jpba.2020.113221] |
| 34. Lei Li, Yan Li, Cheng Miao, Rui Liu. (2020) Improved Therapeutic Effect of Puerarin-Encapsulated PEG-PLGA Nanoparticle on an In Vitro Cerebral Infarction Model. ADVANCES IN POLYMER TECHNOLOGY, 2020 (7145738). [10.1155/2020/7145738] |
| 35. Xue Jintao, Zhou Nanqian, Yang Yuping, Jing Yun, Qiu Yue, Liu Yanhua, Lu Junxiu, Tian Xinqiao, Yin Yaling, Li Peng. (2020) Puerarin-loaded ultrasound microbubble contrast agent used as sonodynamic therapy for diabetic cardiomyopathy rats. COLLOIDS AND SURFACES B-BIOINTERFACES, 190 (110887). [PMID:32113166] [10.1016/j.colsurfb.2020.110887] |
| 36. Lili Guo, Huijun Zheng, Cuijie Zhang, Lingbo Qu, Lanlan Yu. (2020) A novel molecularly imprinted sensor based on PtCu bimetallic nanoparticle deposited on PSS functionalized graphene with peroxidase-like activity for selective determination of puerarin. TALANTA, 210 (120621). [PMID:31987162] [10.1016/j.talanta.2019.120621] |
| 37. Duzhen Zhang, Man Li. (2019) Puerarin prevents cataract development and progression in diabetic rats through Nrf2/HO‑1 signaling. Molecular Medicine Reports, 20 (2): (1017-1024). [PMID:31173182] [10.3892/mmr.2019.10320] |
| 38. Qingqing Hao, Lilin Lu, Xianwen Kan. (2019) Probe and analogue: Double roles of thionine for aloe-emodin selective and sensitive ratiometric detection. SENSORS AND ACTUATORS B-CHEMICAL, 292 (247). [10.1016/j.snb.2019.04.129] |
| 39. Yunbing Shen, Shengnan Yang, Xueyan Hu, Man Zhang, Xiaoyao Ma, Zhihua Wang, Yuanyuan Hou, Gang Bai. (2019) Natural product puerarin activates Akt and ameliorates glucose and lipid metabolism dysfunction in hepatic cells. Journal of Functional Foods, 55 (296). [10.1016/j.jff.2019.02.035] |
| 40. Hucheng Zhang, Yingying Shang, Ting Zhang, Kelei Zhuo, Jianji Wang. (2017) Engineering graphene/quantum dot interfaces for high performance electrochemical nanocomposites in detecting puerarin. SENSORS AND ACTUATORS B-CHEMICAL, 242 (492). [10.1016/j.snb.2016.11.082] |
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| 43. Guiju Xu, Shengju Liu, Jiaxi Peng, Wenping Lv, Ren’an Wu. (2015) Facile Synthesis of Gold@Graphitized Mesoporous Silica Nanocomposite and Its Surface-Assisted Laser Desorption/Ionization for Time-of-Flight Mass Spectroscopy. ACS Applied Materials & Interfaces, 7 (3): (2032–2038). [PMID:25552293] [10.1021/am507894y] |
| 44. Gan Maozhou, Yin Xiaodong. (2015) Puerarin Induced in Mantle Cell Lymphoma Apoptosis and its Possible Mechanisms Involving Multi-signaling Pathway. CELL BIOCHEMISTRY AND BIOPHYSICS, 71 (1): (367-373). [PMID:25173778] [10.1007/s12013-014-0207-y] |
| 45. Xiao-Feng Li, Tingting Yuan, Haixia Xu, Xuan Xin, Guanglei Zhao, Hui Wu, Xinglong Xiao,. (2018-12-19) Whole-Cell Catalytic Synthesis of Puerarin Monoesters and Analysis of Their Antioxidant Activities.. Journal of agricultural and food chemistry, 67 ((1)): ( 299-307 ). [PMID:30558414] |
| 46. Sisi Ke, Ningrui Wang, Xingyu Chen, Jiangwei Tian, Jiwei Li, Boyang Yu. (2025) A Label-Free Colorimetric Aptasensor for Flavokavain B Detection. SENSORS, 25 (2): (569). [PMID:39860936] [10.3390/s25020569] |
| 47. Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou. (2025) Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury. Advanced Science, (2407802). [PMID:40091443] [10.1002/advs.202407802] |
| 48. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang. (2025) An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds. FOOD CHEMISTRY, (143873). [PMID:40120314] [10.1016/j.foodchem.2025.143873] |
| 49. Chenran Xin, Pinhui Jia, Yan Zhao, Zhiqiang Cheng, Wencong Liu, Peng Di, Wei Li, Hongyan Zhu. (2025) Antioxidant effects of Gastrodia elata polysaccharide-based hydrogels loaded with puerarin/gelatin microspheres for D-galactose-induced aging-skin wound healing. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 296 (139809). [PMID:39805458] [10.1016/j.ijbiomac.2025.139809] |
| 50. Wanbing Pan, Rong Sun, Yaoyuan Yu, Yuxin Liu, Yinling Mu, Hanyan Gong, Hongxia Fan, Yingchao Zhang, Lutong He, Haibing He, Jingxin Gou, Xing Tang, Tian Yin, Yu Zhang. (2025) Baicalein nanoemulsion in situ GEL for dry age-related macular degeneration. INTERNATIONAL JOURNAL OF PHARMACEUTICS, (125494). [PMID:40107466] [10.1016/j.ijpharm.2025.125494] |
| 51. Xiaoqiang Wang, Chao Song, Daqian Zhou, Yongliang Mei, Weiye Cai, Rui Chen, Jiale Lv, Houyin Shi, Zongchao Liu. (2024) Exploring the therapeutic potential of puerarin on intervertebral disc degeneration by regulating apoptosis of nucleus pulposus cells. JOR Spine, 7 (4): (e70020). [PMID:39664589] [10.1002/jsp2.70020] |
| 52. Shuyun Zhu, Kunming Sun, Shuyi Liu, Qian Wang, Jiatong Fan, Xian-En Zhao, Guobao Xu. (2025) Fluorescent distinguishing flavonoid glycosides against aglycones based on the selective recognization of boric acid-functional Eu(III)-organic framework. TALANTA, 286 (127559). [PMID:39798417] [10.1016/j.talanta.2025.127559] |
| 53. Ting Li, Wenzhu Wang, Weijin Liu, Mingming Sun, Qiuying Wang, Zihan Li, Jie Hao, Yan Yu. (2025) Macrophage membrane coated functionalized nanoparticles for targeted drug delivery and neural function repair in cerebral ischemia–reperfusion injury. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 672 (125329). [PMID:39923885] [10.1016/j.ijpharm.2025.125329] |
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