| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P407870-1ml |
1ml |
现货  |
|
| 别名 | 吡格列酮 (AD-4833) |
|---|---|
| 英文别名 | U 72107 | 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Pioglitazone (AD-4833) |
| 生化机理 | 吡格列酮（AD-4833，U 72107）是一种选择性过氧化物酶体增殖激活受体-γ（PPARγ）激动剂，用于治疗糖尿病；是全长 hPPARα 的弱激活剂，但不是全长 hPPARδ。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 过氧化物酶体增殖激活受体-γ 的激动剂；TRPM3 的通道阻断剂 |
| 产品介绍 |
Pioglitazone 是一种选择性过氧化物酶体增殖物激活受体γ激动剂。A PPAR agonist with potential antidiabetic characteristics. Information Pioglitazone (AD-4833, U 72107) is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes; A weak activator for full-length hPPARα, but not full-length hPPARδ. Pioglitazone\xa0is\xa0metabolised\xa0mainly by\xa0CYP2C8\xa0and to a lesser extent by\xa0CYP3A4\xa0in\xa0vitro.\xa0 In vivo Pioglitazone\xa0significantly attenuates left\xa0ventricular\xa0(LV) cavity dilatation and dysfunction by echocardiography as well as LV end-diastolic pressure\xa0in mice with extensive anterior myocardial\xa0infarction.\xa0Pioglitazone partially normalizes LV dP/dt(max) and dP/dt(min), indices of LV contractile function, which are significantly reduced in MI mice. Pioglitazone\xa0results in a reduced activation\xa0of microglia, reduced\xa0induction\xa0of\xa0iNOS-positive cells and less glial fibrillary acidic protein positive cells in both striatum and substantia nigra pars compacta of MPTP mouse\xa0model\xa0of\xa0Parkinson\'s\xa0disease. Pioglitazone\xa0almost completely blocks staining of TH-positive neurons for nitrotyrosine, a marker of NO-mediated cell damage.\xa0 Pioglitazone\xa0(approximately 20 mg/kg/day) attenuates the MPTP-induced glial activation and prevents the dopaminergic cell loss in the substantia nigra pars compacta (SNpc) in MPTP mouse\xa0model\xa0of\xa0Parkinson\'s\xa0disease. Pioglitazone results in a reduction in the number of activated microglia and reactive astrocytes in the hippocampus and cortex of 10-month-old\xa0APPV717I\xa0transgenic mice.\xa0Pioglitazone treatment\xa0reduces the expression of the proinflammatory enzymes cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS).\xa0Pioglitazone decreases beta-secretase-1 (BACE1) mRNA and protein\xa0levels, and also a 27% reduction in the\xa0levels\xa0of soluble\xa0Abeta1-42\xa0peptide.\xa0 cell lines： Concentrations： Incubation Time： Powder Purity:≥98% |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3 |
| 关联CAS | 112529-15-4 |
| 分子量 | 356.44 |
| Reaxy-Rn | 3595485 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3595485&ln= |
| 溶解性 | Solubility (25°C) In vitro DMSO: 29 mg/mL (198.43 mM); Water: 29 mg/mL (198.43 mM); Ethanol: 29 mg/mL (198.43 mM); |
|---|
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害 H302+H312+H332: 吞咽，皮肤接触或吸入有害。 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
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