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| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P167764-1mg |
1mg |
现货 ![]() |
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| P167764-5mg |
5mg |
现货 ![]() |
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| P167764-10mg |
10mg |
现货 ![]() |
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| P167764-25mg |
25mg |
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| P167764-50mg |
50mg |
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| 别名 | 12-O-十四烷酰佛波醋酸酯-13 | 4β,9α,12β,13α,20-五羟基噻吩-1,6-二烯-3-酮12-十四烷酸酯13-乙酸酯 | 12-O-十四烷酰基佛波醇13-乙酸酯 |
|---|---|
| 英文别名 | Phorbol 13 Acetate 12 Myristate | (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate | Bio1_001278 | Bio2_0003 |
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Phorbol 12-myristate 13-acetate(PMA) |
| 生化机理 | 佛波醇12-十四酸酯13-乙酸酯是一种有效的肿瘤启动子,在 体内 和 体外都能激活蛋白激酶C。这是一种佛波酯,与许多细胞反应有关,包括基因转录、细胞分裂和分化、凋亡和免疫反应。它还参与蛋白激酶C (PKC)介导的受体脱敏。佛波醇12-十四酸酯13-乙酸酯诱导PKC在细胞质中定位, 使酶与细胞膜结合。 |
| 储存温度 | 避光,-20°C储存,充氩 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激活剂 |
| 作用机制 | K ir3.4的门控抑制剂;K Na1.1的激活剂;K Na1.2的门控抑制剂;TRPV4的激活剂 |
| 备注 | 本产品以一种(或多种)包装尺寸提供,并进行冷冻干燥。因此,内含物可能会覆盖小瓶的底部或壁,因此可能不容易看到。请参阅我们的常见问题解答和信息页面以获取有关处理的更多详细信息。如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 |
| 产品介绍 |
佛波醇12-十四酸酯13-乙酸酯 (PMA) 是一种佛波酯,是蛋白激酶 C (PKC) 和 SphK 的激活剂。Phorbol 12-myristate 13-acetate 是 NF-κB 激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP-1 细胞分化;
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | [(1S,2S,6R,10S,11R,13S,14R,15R)-13-acetyloxy-1,6-dihydroxy-8-(hydroxymethyl)-4,12,12,15-tetramethyl-5-oxo-14-tetracyclo[8.5.0.02,6.011,13]pentadeca-3,8-dienyl] tetradecanoate |
| INCHI | 1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1 |
| InChi Key | PHEDXBVPIONUQT-RGYGYFBISA-N |
| Smiles | CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C |
| Isomeric SMILES | CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C |
| PubChem CID | 27924 |
| UN Number | 2811 |
| Packing Group | I |
| 分子量 | 616.83 |
| 敏感性 | 对光线和空气敏感 |
|---|---|
| 分子量 | 616.800 g/mol |
| XLogP3 | 6.500 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 17 |
| 精确质量Exact Mass | 616.398 Da |
| 单同位素质量Monoisotopic Mass | 616.398 Da |
| 拓扑极表面积Topological Polar Surface Area | 130.000 Ų |
| 重原子数Heavy Atom Count | 44 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 1150.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 8 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理(请参阅此标签上的...)。 P302+P352: 如皮肤沾染:用水充分清洗。 P362+P364: 脱掉沾污的衣服,清洗后方可重新使用。 P332+P317: 如果出现皮肤刺激:请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | QH4377000 |
| Class | 6.1 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 | |
| 分析证书 | P167764 |
¥1,435.90
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