9-菲酚, TRPM4 通道阻断剂

选择性TRPM4阻滞剂

10篇引用文献

COA

级别和纯度:

Moligand™

工业级

CAS编号: 484-17-3
分子式: C₁₄H₁₀O
分子量: 194.23
EC号: 207-602-4
MDL号: MFCD00082298
PubChem编号: 10229
PubChem SID: 504751916

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货号 (SKU)	包装规格	是否现货
P136335-250mg	250mg	现货
P136335-1g	1g	现货
P136335-5g	5g	现货

查看相关系列

TRP Channel (182) TRPM4 Channel blocker (8) 神经元信号传导 (3320) 离子通道 (4087) 膜转运器/离子通道 (1829)

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基本描述

英文别名	HY-108457 \| NSC50554 \| NSC-50554 \| UNII-9FYU45OV9H \| DTXCID7027592 \| DZKIUEHLEXLYKM-UHFFFAOYSA- \| 4-06-00-04937 (Beilstein Handbook Reference) \| Tox21_300618 \| BRN 2047057 \| GTPL4114 \| SY113803 \| Phenanthren-9-ol \| SCHEMBL508755 \| BDBM50526033 \| CCRIS 184
规格或纯度	Moligand™, 工业级
英文名称	9-Phenanthrol
生化机理	选择性TRPM4阻滞剂（IC 50 = 20μM）。调节平滑肌收缩。减少LPS诱导的细胞死亡。促进血管生成。在体内显示出心脏保护和抗缺血作用。
运输条件	常规运输
作用类型	通道阻滞剂
作用机制	TRPM4 通道阻断剂
备注	需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

关联靶点（人）

TRPM4 Tchem 瞬时受体电位阳离子通道亚家族M成员4(Transient receptor potential cation channel subfamily M member 4) (0 活性数据)

点击查看靶蛋白信息： TRPM4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

HL-60 (67320 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504751916
EC号	207-602-4
分子类型	小分子
IIUPAC Name	phenanthren-9-ol
INCHI	1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H
InChi Key	DZKIUEHLEXLYKM-UHFFFAOYSA-N
Smiles	C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O
Isomeric SMILES	C1=CC=C2C(=C1)C=C(C3=CC=CC=C23)O
PubChem CID	10229
分子量	194.23

化学和物理性质

分子量	194.230 g/mol
XLogP3	3.600
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	1
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	194.073 Da
单同位素质量Monoisotopic Mass	194.073 Da
拓扑极表面积Topological Polar Surface Area	20.200 Å²
重原子数Heavy Atom Count	15
形式电荷Formal Charge	0
复杂度Complexity	225.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
WGK Germany	3
RTECS	SF8288000
个人防护装备	dust mask type N95 (US), Eyeshields, Gloves

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批号(Lot Number)	证书类型	货号
A2226113	分析证书	P136335
L2405186	分析证书	P136335
D1903146	分析证书	P136335

此产品的引用文献

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引用文献

1. Guinamard R, Hof T, Del Negro CA. (2014) The TRPM4 channel inhibitor 9-phenanthrol.. Br J Pharmacol, 171 (7): (1600-13). [PMID:24433510]
2. Chun-Ying Xu, Yuan-Yuan Cui, Cheng-Xiong Yang. (2024) Fabrication of magnetic Fe3O4 doped β-cyclodextrin microporous organic network for the efficient extraction of endocrine disrupting chemicals from food takeaway boxes. JOURNAL OF CHROMATOGRAPHY A, 1715 (464625). [PMID:38171066] [10.1016/j.chroma.2023.464625]
3. Kai Hu, Tiantian Pang, Cheng Yang, Pengzhao Han, Lixin Li, Pan Wang, Zhenqiang Zhang, Wenjie Zhao, Shusheng Zhang. (2023) Simultaneous extraction of hydroxylated polycyclic aromatic hydrocarbons and catecholamines with magnetic boronic acid hypercrosslinked polymers. JOURNAL OF CHROMATOGRAPHY A, 1712 (464491). [PMID:37931428] [10.1016/j.chroma.2023.464491]
4. Zhengwen Wei, Yifan Du, Xiang-fei Lü, Wei Wang, Roberta Del Sole, Giuseppe Mele, Zhen-Yi Jiang. (2023) High-performance Fe3O4-terephthalaldehyde magnetic-nanocomposite for removal phenanthrene and 9-phenanthrol: A comprehensive experimental and theoretical analysis. SEPARATION AND PURIFICATION TECHNOLOGY, 306 (122610). [10.1016/j.seppur.2022.122610]
5. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2023) Excellent removal performance of 4,4'-biphenyldicarboxaldehyde m-phenylenediamine Schiff base magnetic polymer towards phenanthrene and 9-phenanthrol: Experimental, modeling and DFT calculations studies. JOURNAL OF HAZARDOUS MATERIALS, 441 (129920). [PMID:36099739] [10.1016/j.jhazmat.2022.129920]
6. Zhengwen Wei, Xiang-fei Lü, Wei Wang, Giuseppe Mele, Zhen-Yi Jiang. (2022) Fe3O4-4,4′-biphenyldicarboxaldehyde superparamagnetic-nanomaterial for the high-efficiency removal of 9-phenanthrol: experimental combined with DFT investigations. Environmental Science-Nano, 9 (9): (3562-3580). [10.1039/D2EN00543C]
7. Sun Fei, Feng Chao, Wang Yang, Yang Xue, Zhao Hong. (2022) Preparation of fluorescent polystyrene microspheres by improving swelling performance based on molecular weight and surface carboxyl group content. QUIMICA NOVA, 45 (2): (145-151). [10.21577/0100-4042.20170808]
8. Xin-Qiao He, Yuan-Yuan Cui, Cheng-Xiong Yang. (2021) Thiol–Yne Click Postsynthesis of a Sulfonate Group-Enriched Magnetic Microporous Organic Network for Efficient Extraction of Benzimidazole Fungicides. ACS Applied Materials & Interfaces, 13 (33): (39905–39914). [PMID:34374514] [10.1021/acsami.1c11148]
9. Xin-Qiao He, Yuan-Yuan Cui, Xiao-Hui Lin, Cheng-Xiong Yang. (2021) Fabrication of polyethyleneimine modified magnetic microporous organic network nanosphere for efficient enrichment of non-steroidal anti-inflammatory drugs from wastewater samples prior to HPLC-UV analysis. TALANTA, 233 (122471). [PMID:34215105] [10.1016/j.talanta.2021.122471]
10. Fan Libing, Ma Qianli, Tian Jiao, Li Dan, Xi Xue, Dong Xiangting, Yu Wensheng, Wang Jinxian, Liu Guixia. (2019) Conjugate Electrospinning Construction of Microyarns with Synchronous Color-Tuned Photoluminescence and Tunable Electrical Conductivity. JOURNAL OF ELECTRONIC MATERIALS, 48 (3): (1511-1521). [10.1007/s11664-018-06914-9]
11. Cholho Choe, Ling Yang, Zhanao Lv, Wanling Mo, Zhuqi Chen, Guangxin Li, Guochuan Yin,. (2015-04-24) Redox-inactive metal ions promoted the catalytic reactivity of non-heme manganese complexes towards oxygen atom transfer.. Dalton transactions (Cambridge, England : 2003), 44 ((19)): ( 9182-9192 ). [PMID:25904197]

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