| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P129662-10mg |
10mg |
现货  |
| |
| P129662-50mg |
50mg |
现货 |
|
| 英文别名 | DTXSID5057670 | PRUCALOPRIDE (MART.) | GTPL243 | L000891 | MFCD09837787 | HY-14151 | PRUCALOPRIDE [USAN] | PRUCALOPRIDE [MART.] | 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide | A06AX05 | BCPP000099 | NCGC00253 |
|---|---|
| 规格或纯度 | Moligand™, ≥99% |
| 英文名称 | Prucalopride |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 激动剂 |
| 作用机制 | 羟色胺 4 (5-HT4) 受体激动剂 |
| 产品介绍 |
Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes. Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes. |
| 纯度 | ≥99% |
| ALogP | 2 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide |
| INCHI | 1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23) |
| InChi Key | ZPMNHBXQOOVQJL-UHFFFAOYSA-N |
| Smiles | COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl |
| Isomeric SMILES | COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl |
| 分子量 | 367.87 |
| Reaxy-Rn | 8357099 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8357099&ln= |
| 溶解性 | DMSO 60 mg/mL Water <1 mg/mL Ethanol 38 mg/mL |
|---|---|
| 敏感性 | 对空气敏感，对热敏感 |
| 熔点 | 92 °C |
| 分子量 | 367.900 g/mol |
| XLogP3 | 2.000 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 367.166 Da |
| 单同位素质量Monoisotopic Mass | 367.166 Da |
| 拓扑极表面积Topological Polar Surface Area | 76.800 Ų |
| 重原子数Heavy Atom Count | 25 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 445.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Kim DY, Camilleri M. (2000) Serotonin: a mediator of the brain-gut connection.. Am J Gastroenterol, 95 (10): (2698-709). [PMID:11051338] |
| 2. Baker DE. (2005) Rationale for using serotonergic agents to treat irritable bowel syndrome.. Am J Health Syst Pharm, 62 (7): (700-11; quiz 712-3). [PMID:15790796] |
| 3. Gershon MD, Tack J. (2007) The serotonin signaling system: from basic understanding to drug development for functional GI disorders.. Gastroenterology, 132 (1): (397-414). [PMID:17241888] |
| 4. Kadowaki M, Wade PR, Gershon MD. (1996) Participation of 5-HT3, 5-HT4, and nicotinic receptors in the peristaltic reflex of guinea pig distal colon.. Am J Physiol, 271 (5 Pt 1): (G849-57). [PMID:8944700] |
| 5. Hansen MB, Skadhauge E. (1997) Signal transduction pathways for serotonin as an intestinal secretagogue.. Comp Biochem Physiol A Physiol, 118 (2): (283-90). [PMID:9366057] |
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