基本描述

别名	苯并氨酰丙氨酸
英文别名	MFCD00037229 \| HY-W009602 \| L-Phe-L-Ala \| Phenylalanine Alanine dipeptide \| SCHEMBL1711543 \| (S)-2-((S)-2-Amino-3-phenyl-propionylamino)-propionic acid \| CHEBI:73630 \| AKOS010420277 \| F-A \| (S)-2-((S)-2-Amino-3-phenylpropanamido)propanoic acid \| Phenylala
规格或纯度	≥98%
英文名称	Phe-Ala
储存温度	避光,-20°C储存,充氩
运输条件	超低温冰袋运输
纯度	≥98%

关联靶点（人）

ACE Tclin Angiotensin-converting enzyme (1423 活性数据)

点击查看靶蛋白信息： ACE

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MME Tclin Neprilysin (838 活性数据)

点击查看靶蛋白信息： MME

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLC15A1 Tchem Oligopeptide transporter small intestine isoform (922 活性数据)

点击查看靶蛋白信息： SLC15A1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

分子类型	小分子
IIUPAC Name	(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]propanoic acid
INCHI	1S/C12H16N2O3/c1-8(12(16)17)14-11(15)10(13)7-9-5-3-2-4-6-9/h2-6,8,10H,7,13H2,1H3,(H,14,15)(H,16,17)/t8-,10-/m0/s1
InChi Key	MIDZLCFIAINOQN-WPRPVWTQSA-N
Smiles	CC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)N
Isomeric SMILES	C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)N
分子量	236.27
Reaxy-Rn	2220412
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2220412&ln=

化学和物理性质

敏感性	对空气敏感；对湿度敏感；对热敏感；对光线敏感
分子量	236.270 g/mol
XLogP3	-2.900
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	4
可旋转键计数Rotatable Bond Count	5
精确质量Exact Mass	236.116 Da
单同位素质量Monoisotopic Mass	236.116 Da
拓扑极表面积Topological Polar Surface Area	92.400 Å²
重原子数Heavy Atom Count	17
形式电荷Formal Charge	0
复杂度Complexity	275.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	2
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

WGK Germany	3

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到10个结果

批号(Lot Number)	证书类型	货号
H2520502	分析证书	P121447
H2520643	分析证书	P121447
H2528730	分析证书	P121447
H2520628	分析证书	P121447
H2520675	分析证书	P121447
H2520623	分析证书	P121447
H2408663	分析证书	P121447
H2408664	分析证书	P121447
H2408665	分析证书	P121447
B1412073	分析证书	P121447

引用文献

1. Wenzel U, Diehl D, Herget M, Daniel H. (1998) Endogenous expression of the renal high-affinity H+-peptide cotransporter in LLC-PK1 cells.. Am J Physiol, 275 (6 Pt 1): (C1573-9). [PMID:9843719]
2. Rühl A, Hoppe S, Frey I, Daniel H, Schemann M. (2005) Functional expression of the peptide transporter PEPT2 in the mammalian enteric nervous system.. J Comp Neurol, 490 (1): (1-11). [PMID:16041713]
3. Rohm F, Skurk T, Daniel H, Spanier B. (2019) Appearance of Di- and Tripeptides in Human Plasma after a Protein Meal Does Not Correlate with PEPT1 Substrate Selectivity.. Mol Nutr Food Res, 63 (5): (e1801094). [PMID:30521147]
4. D Meredith,C A Boyd. (1995-08-01) Dipeptide transport characteristics of the apical membrane of rat lung type II pneumocytes.. The American journal of physiology, 269 ((2 Pt 1)): (L137-L143). [PMID:7653574]
5. F Döring,S Theis,H Daniel. (1997-03-27) Expression and functional characterization of the mammalian intestinal peptide transporter PepT1 in the methylotropic yeast Pichia pastoris.. Biochemical and biophysical research communications, 232 ((3)): (656-662). [PMID:9126331]
6. Knütter I, Theis S, Hartrodt B, Born I, Brandsch M, Daniel H, Neubert K. (2001) A novel inhibitor of the mammalian peptide transporter PEPT1.. Biochemistry, 40 (14): (4454-8). [PMID:11284702]
7. Arakawa H, Yamada H, Arai K, Kawanishi T, Nitta N, Shibata S, Matsumoto E, Yano K, Kato Y, Kumamoto T et al.. (2020) Possible utility of peptide-transporter-targeting [¹⁹F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging.. Int J Pharm, 586 (119575). [PMID:32622809]
8. U Wenzel,D Diehl,M Herget,S Kuntz,H Daniel. (1999-02-16) Regulation of the high-affinity H+/peptide cotransporter in renal LLC-PK1 cells.. Journal of cellular physiology, 178 ((3)): (341-348). [PMID:9989780]
9. C H Görbitz. (2001-05-16) L-Phenylalanyl-L-alanine dihydrate.. Acta crystallographica. Section C, Crystal structure communications, 57 ((Pt 5)): (575-576). [PMID:11353256]
10. I Hussain,T Zanic-Grubisic,Y Kudo,C A Boyd. (2001-12-01) Functional and molecular characterization of a peptide transporter in the rat PC12 neuroendocrine cell line.. FEBS letters, 508 ((3)): (350-354). [PMID:11728450]
11. Jaeseung Kim,Gregory Hewitt,Patrick Carroll,Scott McN Sieburth. (2005-07-16) Silanediol inhibitors of angiotensin-converting enzyme. Synthesis and evaluation of four diastereomers of Phe[Si]Ala dipeptide analogues.. The Journal of organic chemistry, 70 ((15)): (5781-5789). [PMID:16018669]
12. Nick C Polfer,Jos Oomens,Robert C Dunbar. (2008-02-23) Alkali metal complexes of the dipeptides PheAla and AlaPhe: IRMPD spectroscopy.. Chemphyschem : a European journal of chemical physics and physical chemistry, 9 ((4)): (579-589). [PMID:18293344]
13. Esteban E Baquero,William H James,Soo Hyuk Choi,Samuel H Gellman,Timothy S Zwier. (2008-03-19) Single-conformation ultraviolet and infrared spectroscopy of model synthetic foldamers: beta-peptides Ac-beta3-hPhe-beta3-hAla-NHMe and Ac-beta3-hAla-beta3-hPhe-NHMe.. Journal of the American Chemical Society, 130 ((14)): (4795-4807). [PMID:18345673]
14. Sedireng M Ndolo,Kwenga Sichilongo,Amos Massele,Enoch Sepako,Sandro Vento. (2015-10-22) An Investigation of Liquid Chromatography-Mass Spectral Attributes and Analytical Performance Characteristics of Tenofovir, Emtricitabine and Efavirenz in Human Plasma.. Journal of analytical toxicology, 40 ((1)): (49-57). [PMID:26487641]
15. Zhanfei Liu,Shuting Liu. (2015-12-10) High Phosphate Concentrations Accelerate Bacterial Peptide Decomposition in Hypoxic Bottom Waters of the Northern Gulf of Mexico.. Environmental science & technology, 50 ((2)): (676-684). [PMID:26650147]
16. Venkat N Are,Ashwani Kumar,Saurabh Kumar,Venuka Durani Goyal,Biplab Ghosh,Deepak Bhatnagar,Sahayog N Jamdar,Ravindra D Makde. (2016-11-07) Crystal structure and biochemical investigations reveal novel mode of substrate selectivity and illuminate substrate inhibition and allostericity in a subfamily of Xaa-Pro dipeptidases.. Biochimica et biophysica acta, 1865 ((2)): (153-164). [PMID:27816563]
17. Mukul Sonker,Radim Knob,Vishal Sahore,Adam T Woolley. (2017-03-09) Integrated electrokinetically driven microfluidic devices with pH-mediated solid-phase extraction coupled to microchip electrophoresis for preterm birth biomarkers.. Electrophoresis, 38 ((13-14)): (1743-1754). [PMID:28272749]
18. Jenni Tienaho,Maarit Karonen,Riina Muilu-Mäkelä,Kristiina Wähälä,Eduardo Leon Denegri,Robert Franzén,Matti Karp,Ville Santala,Tytti Sarjala. (2019-06-28) Metabolic Profiling of Water-Soluble Compounds from the Extracts of Dark Septate Endophytic Fungi (DSE) Isolated from Scots Pine (Pinus sylvestris L.) Seedlings Using UPLC-Orbitrap-MS.. Molecules (Basel, Switzerland), 24 ((12)): [PMID:31242564]
19. G Borin,P Giusti,L Cima. (1983-10-17) Analgesic properties of N-terminal substituted phenylalanyl-alanine.. Life sciences, 33 ((16)): (1575-1580). [PMID:6355734]
20. J J Chen,L A Barber,J Dymshitz,M R Vasko. (1996-01-01) Peptidase inhibitors improve recovery of substance P and calcitonin gene-related peptide release from rat spinal cord slices.. Peptides, 17 ((1)): (31-37). [PMID:8822507]
21. F Döring,D Dorn,U Bachfischer,S Amasheh,M Herget,H Daniel. (1996-12-15) Functional analysis of a chimeric mammalian peptide transporter derived from the intestinal and renal isoforms.. The Journal of physiology, 497 ( Pt 3) (773-779). [PMID:9003562]
22. A K Stewart,C A Boyd,R D Vaughan-Jones. (1999-03-06) A novel role for carbonic anhydrase: cytoplasmic pH gradient dissipation in mouse small intestinal enterocytes.. The Journal of physiology, 516 ( Pt 1) (209-217). [PMID:10066935]
23. T Verri,M Maffia,A Danieli,M Herget,U Wenzel,H Daniel,C Storelli. (2000-09-08) Characterisation of the H(+)/peptide cotransporter of eel intestinal brush-border membranes.. The Journal of experimental biology, 203 ((Pt 19)): (2991-3001). [PMID:10976035]
24. Jason Lamar,Jingdan Hu,Ana Belen Bueno,Hsiu-Chiung Yang,Deqi Guo,James D Copp,James McGee,Bruce Gitter,David Timm,Patrick May,James McCarthy,Shu-Hui Chen. (2003-12-20) Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR.. Bioorganic & medicinal chemistry letters, 14 ((1)): (239-243). [PMID:14684335]
25. Shu-Hui Chen,Jason Lamar,Deqi Guo,Todd Kohn,Hsiu-Chiung Yang,James McGee,David Timm,Jon Erickson,Yvonne Yip,Patrick May,James McCarthy. (2003-12-20) P3 cap modified Phe*-Ala series BACE inhibitors.. Bioorganic & medicinal chemistry letters, 14 ((1)): (245-250). [PMID:14684336]
26. Robert C Dunbar,Jeffrey D Steill,Jos Oomens. (2010-09-08) Cationized phenylalanine conformations characterized by IRMPD and computation for singly and doubly charged ions.. Physical chemistry chemical physics : PCCP, 12 ((41)): (13383-13393). [PMID:20820591]
27. Marina López-García,Roberto Romero-González,Antonia Garrido Frenich. (2017-02-06) Determination of rodenticides and related metabolites in rabbit liver and biological matrices by liquid chromatography coupled to Orbitrap high resolution mass spectrometry.. Journal of pharmaceutical and biomedical analysis, 137 (235-242). [PMID:28160742]
28. Marina López-García,Roberto Romero-González,Marina Lacasaña,Antonia Garrido Frenich. (2017-09-18) Semiautomated determination of neonicotinoids and characteristic metabolite in urine samples using TurboFlow™ coupled to ultra high performance liquid chromatography coupled to Orbitrap analyzer.. Journal of pharmaceutical and biomedical analysis, 146 (378-386). [PMID:28918328]

溶液计算器

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
P121447-25mg	25mg	现货
P121447-100mg	100mg	现货
P121447-250mg	250mg	现货
P121447-1g	1g	现货
P121447-5g	5g	现货
P121447-25g	25g	现货

苯并氨酰丙氨酸

库存信息

库存信息

库存信息

库存信息

库存信息

库存信息

基本描述

关联靶点（人）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器