葛根素, TRPV4 激活剂

植物来源的异黄酮

61篇引用文献

COA

级别和纯度:

分析标准品

Moligand™

≥98%

CAS编号: 3681-99-0
分子式: C₂₁H₂₀O₉
分子量: 416.38
Beilstein号: 64198
EC号: 609-296-1
MDL号: MFCD00076007
PubChem编号: 5281807

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货号 (SKU)	包装规格	是否现货
P111269-20mg	20mg	现货
P111269-100mg	100mg	现货
P111269-500mg	500mg	现货

查看相关系列

5-HT Receptor (263) Class A GPCR (8201) GPCR/G Protein (3179) TRPV4 Activator (10) 神经元信号传导 (3320)

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基本描述

别名	葛根黄酮
英文别名	AC1NQZ4N \| 7-hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one \| BIDD:ER0101 \| BRN 0064198 \| SureCN8581666 \| Z1494829516 \| Z9W8997416 \| 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy
规格或纯度	Moligand™, 分析标准品, ≥98%
英文名称	Puerarin
生化机理	植物来源的异黄酮。多种药理功能，包括抗氧化剂，抗炎药和抗凋亡药。增强超氧化物歧化酶活性。体内具有神经保护作用和抗缺血作用。口服活性
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
作用类型	激活剂
作用机制	TRPV4 激活剂
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
纯度	≥98%

关联靶点（人）

TRPV4 Tchem 瞬时受体电位阳离子通道亚家族V成员4(Transient receptor potential cation channel subfamily V member 4) (0 活性数据)

点击查看靶蛋白信息： TRPV4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CA12 Tclin 碳酸酐酶12(Carbonic anhydrase 12) (1 活性数据)

点击查看靶蛋白信息： CA12

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CA7 Tclin 碳酸酐酶7(Carbonic anhydrase 7) (1 活性数据)

点击查看靶蛋白信息： CA7

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CA2 Tclin Carbonic anhydrase II (17698 活性数据)

点击查看靶蛋白信息： CA2

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

ESR1 Tclin Estrogen receptor alpha (17718 活性数据)

点击查看靶蛋白信息： ESR1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

FABP4 Tchem Fatty acid binding protein adipocyte (764 活性数据)

点击查看靶蛋白信息： FABP4

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CA1 Tclin Carbonic anhydrase I (13240 活性数据)

点击查看靶蛋白信息： CA1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CA12 Tclin Carbonic anhydrase XII (6231 活性数据)

点击查看靶蛋白信息： CA12

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MGLL Tchem Monoglyceride lipase (1909 活性数据)

点击查看靶蛋白信息： MGLL

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 (580 活性数据)

点击查看靶蛋白信息： SLCO2B1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Ca7 Carbonic anhydrase VII (3 活性数据)

点击查看靶蛋白信息： Ca7

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

CA4 Carbonic anhydrase IV (1713 活性数据)

点击查看靶蛋白信息： CA4

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

3T3-L1 (3664 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 活性数据)

点击查看靶蛋白信息： rep

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)

点击查看靶蛋白信息： Txnrd1

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

EC号	609-296-1
分子类型	小分子
IIUPAC Name	7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
INCHI	1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1
InChi Key	HKEAFJYKMMKDOR-VPRICQMDSA-N
Smiles	C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O
Isomeric SMILES	C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)O
关联CAS	3681-99-0
MeSH Entry Terms	7,4'-dihydroxyisoflavone-8beta-glucopyranoside;kakonein;puerarin
分子量	416.38
Beilstein号	64198
Reaxy-Rn	1359060
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1359060&ln=

化学和物理性质

密度	1.642
敏感性	对空气&热&湿度敏感
熔点	187-189°C
分子量	416.400 g/mol
XLogP3	0.000
氢键供体数Hydrogen Bond Donor Count	6
氢键受体数Hydrogen Bond Acceptor Count	9
可旋转键计数Rotatable Bond Count	3
精确质量Exact Mass	416.111 Da
单同位素质量Monoisotopic Mass	416.111 Da
拓扑极表面积Topological Polar Surface Area	157.000 Å²
重原子数Heavy Atom Count	30
形式电荷Formal Charge	0
复杂度Complexity	659.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	5
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
RTECS	UO5216000
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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找到7个结果

批号(Lot Number)	证书类型	货号
H2231769	分析证书	P111269
D2423014	分析证书	P111269
D2423031	分析证书	P111269
H2231764	分析证书	P111269
G2314128	分析证书	P111269
H2231612	分析证书	P111269
L2308013	分析证书	P111269

技术文档和文章

异黄酮

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癌症抗氧化能力防紫外线

Isoflavones

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Cancer antioxidant capacity UV protection

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引用文献

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3. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu. (2023) Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies. Food Chemistry-X, 20 (101023). [PMID:38144792] [10.1016/j.fochx.2023.101023]
4. Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. (2024) Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 238 (106450). [PMID:38143010] [10.1016/j.jsbmb.2023.106450]
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15. Xiaoxiang Gao, Chenbo Yue, Ruocen Tian, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Qixiao Zhai. (2023) The regulatory effects of specific polyphenols on Akkermansia are dependent on uridine. FOOD CHEMISTRY, 410 (135367). [PMID:36610089] [10.1016/j.foodchem.2022.135367]
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