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1,10-菲罗啉(无水), TAS2R5 的激动剂

膜渗透性螯合剂。金属蛋白酶抑制剂。
331篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
P111141-5g
 5g 现货 Stock Image
P111141-10g
 10g 现货 Stock Image
P111141-25g
 25g 现货 Stock Image
P111141-100g
 100g 现货 Stock Image
P111141-500g
 500g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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Amino Acid/Protein Metabolism (4559) Metabolic Enzyme/Protease (4889) MMP (148) 菲咯啉配体 (5)
main product photo

基本描述

别名 1,10-菲咯啉 | 邻菲罗啉 | 邻啡啰啉 | 新铜试剂
英文别名 NCGC00091201-03 | 1,10 phenanthroline | s6830 | STL069281 | AMY25754 | NCGC00013043-08 | P0221 | 1,10-phenanthroline | HY-W004544 | NCGC00013043-10 | NCGC00091201-02 | DB02365 | NSC 4265 | 1,10-Fenanthrolin [Czech] | 1.10-phenanthroline | AC-18353 | phen
规格或纯度 Moligand™, ≥99%
英文名称 1,10-Phenanthroline
生化机理 膜渗透性螯合剂。金属蛋白酶抑制剂。螯合细胞内重金属，包括锌，铜和铁。结合DNA并调节体内外多种信号通路。
储存温度 充氩
运输条件 常规运输
作用类型 激动剂
作用机制 TAS2R5 的激动剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

1,10-菲咯啉可用作：
阴极缓冲层，以提高有机太阳能电池的效率。
常规螯合剂，用于研究其在Fenton反应-鲁米诺化学发光系统中的功效。
温和的铜(II)催化有机硼酸和亚磺酸盐的交叉偶联的配体，从而形成芳基和烯基砜。
一种用于金属分光光测定和二氧化碳光催化还原的通用配体。
金属大环化合物合成砌块。

1,10-Phenanthroline is a versatile ligand employed in the spectrophotometric determination of metals and photocatalytic reduction of carbon dioxide. Building block for metallomacrocycles. Ligand used in a mild, copper (II)-catalyzed cross-coupling of organoboronic acids and sulfinate salts leading to aryl- and alkenylsulfones.
A ligand employed in the spectrophotometric determination of metals and photocatalytic reduction of carbon dioxide.

Purpose

1,10-Phenanthroline can be used as:
A cathode buffer layer to improve the efficiency of organic solar cells.
A conventional chelator to study its efficacy in Fenton′s reaction-luminol chemiluminescence system
A ligand in mild, copper (II)-catalyzed cross-coupling of organoboronic acids and sulfinate salts, leading to aryl- and alkenylsulfones.
A versatile ligand employed in the spectrophotometric determination of metals and photocatalytic reduction of carbon dioxide
A building block for metallomacrocycles.
纯度 ≥99%

关联靶点（人）

TAS2R5 Tchem 型味觉受体成员 5(Taste receptor type 2 member 5) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TYR Tclin Tyrosinase (717 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TNF Tclin TNF-alpha (1897 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THRB Tclin Thyroid hormone receptor beta-1 (7926 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CPA1 Tchem Carboxypeptidase A1 (146 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CCR1 Tchem C-C chemokine receptor type 1 (1730 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CCR5 Tclin C-C chemokine receptor type 5 (5640 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APP Tclin Amyloid-beta A4 protein (8510 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ARSA Tbio Cerebroside-sulfatase (655 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MMP3 Tchem Matrix metalloproteinase 3 (3433 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MMP8 Tchem Matrix metalloproteinase 8 (1942 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HSP90AA1 Tchem Heat shock protein HSP 90-alpha (4115 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GALR2 Tchem Galanin receptor 2 (360 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MMP1 Tchem Matrix metalloproteinase-1 (7046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TP53 Tchem Cellular tumor antigen p53 (48468 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NHDF (1164 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SH-SY5Y (11521 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BJ (6930 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A2780 (11979 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Lymphoblastoid cell (5959 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FEN1 Tchem Flap endonuclease 1 (12055 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CCR8 Tchem C-C chemokine receptor type 8 (339 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTT Tchem Huntingtin (19182 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
THPO Tbio Thrombopoietin (834 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EYA2 Tbio Eyes absent homolog 2 (5884 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mmp13 Matrix metalloproteinase 13 (19 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mmp2 Matrix metalloproteinase-2 (12 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
npr Thermolysin (425 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Saccharomyces cerevisiae (19171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mycolicibacterium smegmatis (8003 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Plasmodium falciparum (966862 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Toxoplasma gondii (4585 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ScN2a (522 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
pfk 6-phospho-1-fructokinase (7870 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
blaVIM-2 Beta-lactamase VIM-2 (381 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Danio rerio (3092 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
blaVIM-13 Class B carbapenemase VIM-13 (33 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
blaVIM Beta-lactamase VIM-1 (33 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ATP-dependent molecular chaperone HSP82 (2186 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
nfo Endonuclease 4 (425 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NS1 Nonstructural protein 1 (33327 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TIM23 Mitochondrial import inner membrane translocase subunit TIM23 (781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TIM10 Mitochondrial import inner membrane translocase subunit TIM10 (1435 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HSP90 (947 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
prtC Collagenase (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
recD Exodeoxyribonuclease V (225 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Metallo-beta-lactamase type 2 (11 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Snake venom metalloproteinase neuwiedase (15 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488179615
EC号 200-629-2
分子类型 小分子
IIUPAC Name 1,10-phenanthroline
INCHI 1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H
InChi Key DGEZNRSVGBDHLK-UHFFFAOYSA-N
Smiles C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
Isomeric SMILES C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
UN Number 2811
分子量 180.21
Reaxy-Rn 126461
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=126461&ln=

化学和物理性质

溶解性 Soluble in acetone and ethanol. Slightly soluble in water.
敏感性 对湿度敏感
闪点(℃) >330°
熔点 114-120（℃）
分子量 180.200 g/mol
XLogP3 1.800
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 0
精确质量Exact Mass 180.069 Da
单同位素质量Monoisotopic Mass 180.069 Da
拓扑极表面积Topological Polar Surface Area 25.800 Ų
重原子数Heavy Atom Count 14
形式电荷Formal Charge 0
复杂度Complexity 182.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS06,   GHS09
信号词 危险
危险声明

H301: 吞咽会中毒

H410: 对水生生物有剧毒并具有长期持续影响
预防措施声明

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P273: 避免释放到环境中。

P391: 收集溢出物

P301+P310: 如误吞咽：立即呼叫急救中心/医生。

P405: 密闭存放
WGK Germany 3
RTECS SF8300000
Merck Index 7214
个人防护装备 Eyeshields,Faceshields,Gloves,type P2 (EN 143) respirator cartridges

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批号(Lot Number) 证书类型 货号
L2125060 分析证书 P111141
L2125062 分析证书 P111141
F2524661 分析证书 P111141
F2524662 分析证书 P111141
F2524663 分析证书 P111141
L2207962 分析证书 P111141
F2123298 分析证书 P111141
L2419588 分析证书 P111141
A2419589 分析证书 P111141
L2419591 分析证书 P111141
L2419594 分析证书 P111141
B2306990 分析证书 P111141
L2207875 分析证书 P111141
L2207928 分析证书 P111141
L2207958 分析证书 P111141
G2304050 分析证书 P111141
C2407311 分析证书 P111141
E2408038 分析证书 P111141
H2422002 分析证书 P111141
K2405041 分析证书 P111141
J2318785 分析证书 P111141
K2330113 分析证书 P111141
A2409074 分析证书 P111141
B2527328 分析证书 P111141

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此产品的引用文献

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引用文献

1. FELBER JP, COOMBS TL, VALLEE BL.  (1962)  The mechanism of inhibition of carboxypeptidase A by 1,10-phenanthroline..  Biochemistry,  1  (231-8).  [PMID:13892106]
2. Miziołek B et al..  (2020)  Significance of the angiotensin I/angiotensin II/angiotensin-(1-7) axis in the pathogenesis of systemic sclerosis..  J Eur Acad Dermatol Venereol,  34  (3): (558-564).  [PMID:31746507]
3. Stephan Schreml,Robert J Meier,Katharina T Weiß,Julia Cattani,Dagmar Flittner,Sebastian Gehmert,Otto S Wolfbeis,Michael Landthaler,Philipp Babilas.  (2012-11-23)  A sprayable luminescent pH sensor and its use for wound imaging in vivo..  Experimental dermatology,  21  ((12)): (951-953).  [PMID:23171458]
4. Liao-Yuan Yao,Zheng-Su Yu,Lin Qin,Yi-Zhi Li,Yu Qin,Shu-Yan Yu.  (2012-12-22)  Self-assembly of metallomacrocycles with dipyrazole ligands and anion sensing of [Pd4Fe2] macrocycle with ferrocene-based dipyrazole ligand..  Dalton transactions (Cambridge, England : 2003),  42  ((10)): (3447-3454).  [PMID:23258755]
5. Lijuan Zhang,Xiaorui Zheng,Waqar Ahmad,Yunshan Zhou,Yugang An.  (2012-12-29)  A new and efficient luminescence enhancement system of Eu-N-(3,5-dibromosalicylidene)-2-aminopyridine-1,10-phenanthroline and its application in the determination of trace amounts of europium..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  104  (243-249).  [PMID:23270883]
6. K R Sangeetha Gowda,H S Bhojya Naik,B Vinay Kumar,C N Sudhamani,H V Sudeep,T R Ravikumar Naik,G Krishnamurthy.  (2013-01-15)  Synthesis, antimicrobial, DNA-binding and photonuclease studies of cobalt(III) and nickel(II) Schiff base complexes..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  105  (229-237).  [PMID:23314217]
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