| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P109977-20mg |
20mg |
现货  |
|
| 别名 | 云杉新甙 | 白藜芦醇甙 | 白藜芦醇 3-O-β- D -吡喃葡萄糖苷 | 雷帕霉素-3-β-单- D -葡糖苷 |
|---|---|
| 英文别名 | beta-D-Glucopyranoside, 3-hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-, (E)- | resveratrol-3-O-b-mono-D-glucoside | (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-oxidanyl-phenoxy]oxane-3,4,5-triol | (E)-Piceid | 3,4'-5-TRIHYD |
| 规格或纯度 | 分析标准品 |
| 英文名称 | Polydatin |
| 生化机理 | 芪药材中发现。具抗氧化剂，抗炎和神经保护作用。 |
| 应用 | 虎杖甙，一种多酚的植物抗毒素，具有多种生理和药理作用，包括抗炎和抗氧化活性。 |
| 储存温度 | 2-8°C储存,充氩 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
为蓼科植物虎杖根，何首乌根；松科库页云杉树皮；桃金娘科桉树属等。主要来源于蓼科植物虎杖Polygonum cuspidatum Sieb. et Zucc.的干燥根茎和根。虎杖甙是其中一种天然活性成分,为白色针状结晶粉末。易溶于甲醇、乙醇、乙酸乙酯，微溶于水。虎杖甙，一种多酚的植物抗毒素，具有多种生理和药理作用，包括抗炎和抗氧化活性。 Polydatin is the glycoside of Resveratrol originally isolated from the Chinese herb Polygonum cuspidatum. The compound has been shown to inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. Myocardial cell, white blood cell, vascular smooth muscle cell, and endothelial cell studies report that Polydatin can inhibit ICAM-1 expression, elevate Ca2+, weaken white blood cell-endothelial cell adhesion, and activate KATP channels. |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (2S,3R,4S,5S,6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| INCHI | 1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16-,17-,18+,19-,20-/m1/s1 |
| InChi Key | HSTZMXCBWJGKHG-CUYWLFDKSA-N |
| Smiles | C1=CC(=CC=C1C=CC2=CC(=CC(=C2)OC3C(C(C(C(O3)CO)O)O)O)O)O |
| Isomeric SMILES | C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)O |
| 关联CAS | 65914-17-2 |
| 分子量 | 390.39 |
| Beilstein号 | 17(4)3001 |
| Reaxy-Rn | 1604738 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1604738&ln= |
| 溶解性 | Soluble in water (<1 mg/ml at 25 °C), DMSO (78 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), methanol, and ethyl acetate. |
|---|---|
| 敏感性 | 对热敏感；对空气敏感 |
| 比旋光度 | -54 ° (C=1, Acetone) |
| 熔点 | 223-226°C |
| 分子量 | 390.400 g/mol |
| XLogP3 | 1.700 |
| 氢键供体数Hydrogen Bond Donor Count | 6 |
| 氢键受体数Hydrogen Bond Acceptor Count | 8 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 390.131 Da |
| 单同位素质量Monoisotopic Mass | 390.131 Da |
| 拓扑极表面积Topological Polar Surface Area | 140.000 Ų |
| 重原子数Heavy Atom Count | 28 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 506.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 5 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS05, GHS07 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H315: 引起皮肤刺激 H318: 造成严重的眼睛损伤 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P305+P354+P338: 如果进入眼睛：立即用水冲洗几分钟。取下隐形眼镜（如果有的话），并且操作简单。继续冲洗。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| 1. Shilin Zhou, Yuxuan Sun, Kaidi Wang, Xintao Gao, Kehong Dong, Jing Wang, Xiaochen Wu, Chuanlong Guo. (2024) Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo. FOOD AND CHEMICAL TOXICOLOGY, 184 (114427). [PMID:38160781] [10.1016/j.fct.2023.114427] |
| 2. Qing Yao, Jinyao Ye, Yahui Chen, Lihui Huang, Lining Sun, Zhinan He, Jianing Wu, Yingyi Zhao, Xinyu Zhao, Aimin Cai, Xiandan Chen, Hailun Zheng, Aliaksei Sysa, Congying Xie, Ruijie Chen, Longfa Kou. (2023) Modulation of glucose metabolism through macrophage-membrane-coated metal-organic framework nanoparticles for triple-negative breast cancer therapy. CHEMICAL ENGINEERING JOURNAL, (148069). [10.1016/j.cej.2023.148069] |
| 3. Yajie Zhang, Changjiao Shang, Chaofan Sun, Lingling Wang. (2024) Simultaneously regulating absorption capacities and antioxidant activities of four stilbene derivatives utilizing substitution effect: A theoretical and experimental study against UVB radiation. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 304 (123325). [PMID:37678043] [10.1016/j.saa.2023.123325] |
| 4. Kang Du, Qun Zhou, Ziwen Wang, Chou Mo, Wanwen Dong, Ning Wei, Wenshen Zhong, Yuejiao You, Yifei Wang, Zhiping Wang. (2023) Polydatin ameliorates inflammation and oxidative stress associated with MSU-induced gouty arthritis in mice by regulating PPAR-γ and ferritin activation. LIFE SCIENCES, 326 (121766). [PMID:37209866] [10.1016/j.lfs.2023.121766] |
| 5. Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao. (2023) Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6′/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 71 (20): (7689–7702). [PMID:37167604] [10.1021/acs.jafc.3c00527] |
| 6. Chen-Xi He, Yu-Shi Shen, Mei-Yan Ling, Xiao-Hui Yao, Tao Chen, Wei-Guo Zhao, Dong-yang Zhang. (2023) A porous directional channel xylem reactor based on a continuous fluid catalysis process applied to the conversion of polydatin to resveratrol. Sustainable Chemistry and Pharmacy, 33 (101082). [10.1016/j.scp.2023.101082] |
| 7. Xu Lingfeng, Zou Ying, Wu Kui, Han Runlin, Huang Yanrong, Yi Xiuguang. (2023) Polydatin-based natural product as an activatable molecular sensor toward viscosity detection in liquid. Journal of Food Measurement and Characterization, 17 (4): (3918-3926). [10.1007/s11694-023-01920-w] |
| 8. Qiaoyu He, Yumeng Shi, Hong Xing, Qian Tang, Jing Liu, Chunxia Li, Han Zhang, Boli Zhang, Junhua Zhang, Xiaopeng Chen. (2022) Modulating effect of Xuanfei Baidu granule on host metabolism and gut microbiome in rats.. Frontiers in Pharmacology, 13 (922642-922642). [PMID:36147334] [10.3389/fphar.2022.922642] |
| 9. Li-Ming Yu, Xue Dong, Ning Li, Hui Jiang, Ji-Kai Zhao, Yin-Li Xu, Deng-Yue Xu, Xiao-Dong Xue, Zi-Jun Zhou, Yu-Ting Huang, Qiu-Sheng Zhao, Zhi-Shang Wang, Zong-Tao Yin, Hui-Shan Wang. (2022) Polydatin attenuates chronic alcohol consumption-induced cardiomyopathy through a SIRT6-dependent mechanism. Food & Function, 13 (13): (7302-7319). [PMID:35726783] [10.1039/D2FO00966H] |
| 10. Yanan Chen, Yue Li, Peilu Jia, Shuli Ji, Hao Zhang, Tian Wang. (2022) Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance. Antioxidants, 11 (4): (666). [PMID:35453351] [10.3390/antiox11040666] |
| 11. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang. (2021) Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1178 (122767). [PMID:34224966] [10.1016/j.jchromb.2021.122767] |
| 12. Shengyu Sun, Yourui Zou, Shaocai Hao, Zhanfeng Niu, Liang Wu. (2021) Polydatin inhibits LPS-induced inflammatory response in BV2 microglia by disrupting the formation of lipid rafts. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 43 (2): (138-144). [PMID:33509007] [10.1080/08923973.2020.1867999] |
| 13. Lijuan Wang, Liji Huang, Nan Li, Junjun Miao, Wei Liu, Jiangyi Yu. (2019) Ameliorative effect of polydatin on hyperglycemia and renal injury in streptozotocin-induced diabetic rats. CELLULAR AND MOLECULAR BIOLOGY, 65 (7): [10.14715/cmb/2019.65.7.10] |
| 14. Jianle Wang, Chongan Huang, Zongze Lin, Xiangxiang Pan, Jiaoxiang Chen, Gang Zheng, Naifeng Tian, Yingzhao Yan, Zengjie Zhang, Jianing Hu, Pu Cheng, Xiangyang Wang, Xiaolei Zhang. (2018) Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 22 (11): (5720-5731). [PMID:30358118] [10.1111/jcmm.13848] |
| 15. Meihui Chen, Yu Hou, Dingkun Lin. (2016) Polydatin Protects Bone Marrow Stem Cells against Oxidative Injury: Involvement of Nrf 2/ARE Pathways. Stem Cells International, 2016 (9394150). [PMID:27022401] [10.1155/2016/9394150] |
| 16. Benguo Liu, Yun Li, Huizhi Xiao, Yonglan Liu, Haizhen Mo, Hanjun Ma, Guizhao Liang. (2015) Characterization of the Supermolecular Structure of Polydatin/6-O-α-Maltosyl-β-cyclodextrin Inclusion Complex. JOURNAL OF FOOD SCIENCE, 80 (6): (C1156-C1161). [PMID:25916244] [10.1111/1750-3841.12845] |
| 17. Li Zhang, Yuanyuan Li, Zhiwen Gu, Yuyue Wang, Mei Shi, Yun Ji, Jing Sun, Xiaopeng Xu, Lirong Zhang, Jingtin Jiang, Weifeng Shi. (2015) Resveratrol Inhibits Enterovirus 71 Replication and Pro-Inflammatory Cytokine Secretion in Rhabdosarcoma Cells through Blocking IKKs/NF-κB Signaling Pathway. PLoS One, 10 (2): (e0116879). [PMID:25692777] [10.1371/journal.pone.0116879] |
| 18. Dan Tang,Jia-Xiao Zhu,An-Guo Wu,You-Hua Xu,Ting-Ting Duan,Zhao-Guang Zheng,Ru-Shang Wang,Dan Li,Quan Zhu. (2013-03-16) Pre-column incubation followed by fast liquid chromatography analysis for rapid screening of natural methylglyoxal scavengers directly from herbal medicines: case study of Polygonum cuspidatum.. Journal of chromatography. A, 1286 (102-110). [PMID:23489496] |
| 19. Yanhong Bi, Ruiping Fu, Weiliang Hua, Xinyu Xiong, Chun Zhu, Xiaobao Nie, Zhaoyu Wang. (2025) An empirical exploration of the capacity of choline chloride/lactic acid eutectics to extract and stabilize natural polyhydroxy compounds. FOOD CHEMISTRY, (143873). [PMID:40120314] [10.1016/j.foodchem.2025.143873] |
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