| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| P107673-5mg |
5mg |
现货  |
| |
| P107673-20mg |
20mg |
现货 |
|
| 别名 | 土荆皮乙酸,土荆乙酸 | 土槿皮乙酸B | 土槿乙酸B |
|---|---|
| 英文别名 | Pseudolaric-Acid-B | Pseudolaric acid B | BCP07962 | CHEBI:189471 | (2E,4E)-5-[(1S,7S,8S,9R)-7-Acetyloxy-4-methoxycarbonyl-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-en-9-yl]-2-methylpenta-2,4-dienoic acid | Q-100841 | PD087135 | Pseudolaric acid |
| 规格或纯度 | 分析标准品, ≥98% |
| 英文名称 | Pseudolaric Acid B |
| 应用 | 土槿皮乙酸（PseudolaricacidB，PAB）是中药土槿皮（土荆皮）的主要成分，具有独特的二萜结构母核。近来，上海药物所研究人员首次发现该化合物具有显著的抗肿瘤新生血管形成的作用，其作用机制是通过加速蛋白酶体降解新生血管生成关键因子HIF-1，减少其蓄积，从而抑制新生血管生成。肿瘤新生血管系统是目前抗肿瘤药物研究领域的热点和重要靶标。 |
| 储存温度 | 2-8°C储存,避光 |
| 运输条件 | 冰袋运输 |
| 产品介绍 |
Pseudolaric Acid B 是一种从 Pseudolarix kaempferi (pinaceae) 根部分离的二萜酸，具有抗癌、抗真菌、抗受精活性，并对 T 淋巴细胞也具有免疫抑制活性。Pseudolaric Acid B 通过凋亡和细胞周期阻滞抑制乙肝病毒 (HBV) 的分泌。Pseudolaric Acid B 诱导细胞自噬。
|
| 纯度 | ≥98% |
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (2E,4E)-5-[(1S,7S,8S,9R)-7-acetyloxy-4-methoxycarbonyl-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-en-9-yl]-2-methylpenta-2,4-dienoic acid |
| INCHI | 1S/C23H28O8/c1-14(18(25)26)6-5-10-21(3)17-9-12-22(20(28)31-21)11-7-16(19(27)29-4)8-13-23(17,22)30-15(2)24/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,25,26)/b10-5+,14-6+/t17-,21+,22-,23-/m0/s1 |
| InChi Key | VDGOFNMYZYBUDT-YCONPBHISA-N |
| Smiles | CC(=CC=CC1(C2CCC3(C2(CCC(=CC3)C(=O)OC)OC(=O)C)C(=O)O1)C)C(=O)O |
| Isomeric SMILES | C/C(=C\C=C\[C@@]1([C@@H]2CC[C@]3([C@@]2(CCC(=CC3)C(=O)OC)OC(=O)C)C(=O)O1)C)/C(=O)O |
| 分子量 | 432.464 |
| Reaxy-Rn | 24931609 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24931609&ln= |
| 密度 | 1.29 |
|---|---|
| 敏感性 | 对光线敏感 |
¥199.90
¥1,999.90
¥576.72
| 1. Miao ZH, Feng JM, Ding J. (2012) Newly discovered angiogenesis inhibitors and their mechanisms of action.. Acta Pharmacol Sin, 33 (9): (1103-11). [PMID:22922347] |
| 2. Jinghua Yu,Xiangru Li,Shin-ichi Tashiro,Satoshi Onodera,Takashi Ikejima. (2008-07-19) Bcl-2 family proteins were involved in pseudolaric acid B-induced autophagy in murine fibrosarcoma L929 cells.. Journal of pharmacological sciences, 107 ((3)): (295-302). [PMID:18635920] |
| 3. Jing-hua Yu,Hong-jun Wang,Xiang-ru Li,Shin-ichi Tashiro,Satoshi Onodera,Takashi Ikejima. (2008-08-23) Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells.. Acta pharmacologica Sinica, 29 ((9)): (1069-1076). [PMID:18718176] |
| 4. Barry M Trost,Jerome Waser,Arndt Meyer. (2008-11-13) Total synthesis of (-)-pseudolaric acid B.. Journal of the American Chemical Society, 130 ((48)): (16424-16434). [PMID:18998641] |
| 5. Quan-Bin Han,Lina Wong,Fanny Lai,Nian-Yun Yang,Jing-Zheng Song,Chun-Feng Qiao,Hong-Xi Xu. (2008-12-17) Preparative isolation of pseudolaric acids A and B, and their glucosides from the root bark of Pseudolarix kaempferi using high-speed counter-current chromatography.. Journal of separation science, 32 ((2)): (309-313). [PMID:19072902] |
| 6. Ai-guo Meng,Ling-ling Jiang. (2009-03-24) Induction of G2/M arrest by pseudolaric acid B is mediated by activation of the ATM signaling pathway.. Acta pharmacologica Sinica, 30 ((4)): (442-450). [PMID:19305423] |
| 7. Pauline Chiu,Lai To Leung,Ben C B Ko. (2010-04-21) Pseudolaric acids: isolation, bioactivity and synthetic studies.. Natural product reports, 27 ((7)): (1066-1083). [PMID:20405078] |
| 8. Yun Hu,Xiao-ke Wu,Li-hui Hou. (2010-10-12) [Study on the apoptosis inducing effect of pseudolaric acid B on cervical carcinoma cell line HeLa cells].. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 30 ((7)): (720-722). [PMID:20929130] |
| 9. Na Guo,Guanghui Ling,Xiaoying Liang,Jing Jin,Junwen Fan,Jiazhang Qiu,Yu Song,Ning Huang,Xiuping Wu,Xuelin Wang,Xuming Deng,Xuliang Deng,Lu Yu. (2011-09-14) In vitro synergy of pseudolaric acid B and fluconazole against clinical isolates of Candida albicans.. Mycoses, 54 ((5)): (e400-e406). [PMID:21910756] |
| 10. Peng Liu,Man Xu,Hong-zhu Guo,Jiang-hao Sun,Hui Guo,Shi-feng Sun,De-an Guo. (2012-01-21) [Metabolic pathway and metabolites of pseudolaric acid B].. Yao xue xue bao = Acta pharmaceutica Sinica, 46 ((11)): (1361-1365). [PMID:22260030] |
| 11. Jingtao Liu,Wei Guo,Bo Xu,Fuxiang Ran,Mingming Chu,Hongzheng Fu,Jingrong Cui. (2012-05-04) Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil.. Acta biochimica et biophysica Sinica, 44 ((6)): (490-502). [PMID:22551583] |
| 12. Taradas Sarkar,Tam Luong Nguyen,Zhi-Wei Su,Jun Hao,Ruoli Bai,Rick Gussio,Samuel X Qiu,Ernest Hamel. (2012-05-29) Interaction of pseudolaric acid B with the colchicine site of tubulin.. Biochemical pharmacology, 84 ((4)): (444-450). [PMID:22634405] |
| 13. Xia Mai,Zhong-Wei Xu,Xiao-Yi Chen,Bo Cao,Rui-Cheng Xu. (2013-02-05) [Cycle arrest of prostate carcinoma DU-145 cells induced by pseudolaric acid B].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37 ((22)): (3467-3471). [PMID:23373223] |
| 14. Sheng-Ping Yang,Yu-Jun Cai,Bang-Le Zhang,Lin-Jiang Tong,Hua Xie,Yan Wu,Li-Ping Lin,Jian Ding,Jian-Min Yue. (2007-12-15) Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure-activity relationship study.. Journal of medicinal chemistry, 51 ((1)): (77-85). [PMID:18078313] |
| 15. Bo Cao,Meng-Chen Jiang,Zhi-Yong Lei,Shu-Fang Bai,Hong Chen. (2008-02-07) Effects of PLAB on apoptosis and Smad signal pathway of hypertrophic scar fibroblasts.. Journal of Asian natural products research, 10 ((1-2)): (147-157). [PMID:18253883] |
| 16. Xiaoyuan Lei,Liang Kong,Hanfa Zou,Hong Ma,Ling Yang. (2008-06-25) Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry.. Journal of chromatography. A, 1216 ((11)): (2179-2184). [PMID:18573500] |
| 17. Tan Li,Hong Chen,Zhen Yang,Na Wei,Shi Zhang,Xin Mei,Shu-Fang Bai. (2012-01-24) Topical application of Pseudolaric acid B improve DNFB-induced contact hypersensitivity via regulating the balance of Th1/Th17/Treg cell subsets.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 45 ((5)): (668-676). [PMID:22266211] |
| 18. Gengqing Qu,Yuwen Sheng,Bo Chen,Ben Liu,Lichun Yu. (2012-03-01) [Effects of pseudolaric acid B on apoptosis of bladder cancer cell 5637].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36 ((24)): (3535-3538). [PMID:22368873] |
| 19. Dandan Zhao,Feng Lin,Xingde Wu,Qinshi Zhao,Binjiahui Zhao,Ping Lin,Yanlong Zhang,Xiaoguang Yu. (2012-03-06) Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells.. Toxicology in vitro : an international journal published in association with BIBRA, 26 ((4)): (595-602). [PMID:22388098] |
| 20. Bing Yu,Mei-Hong Li,Wei Wang,Ying-Qing Wang,Yi Jiang,Sheng-Ping Yang,Jian-Min Yue,Jian Ding,Ze-Hong Miao. (2012-03-13) Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model.. Journal of molecular medicine (Berlin, Germany), 90 ((8)): (971-981). [PMID:22406864] |
| 21. Min Qi,Guodong Yao,Simiao Fan,Weiwei Cheng,Shin-Ichi Tashiro,Satoshi Onodera,Takashi Ikejima. (2012-03-15) Pseudolaric acid B induces mitotic catastrophe followed by apoptotic cell death in murine fibrosarcoma L929 cells.. European journal of pharmacology, 683 ((1-3)): (16-26). [PMID:22414811] |
| 22. Min Qi,Simiao Fan,Guodong Yao,Zhao Li,Haiyan Zhou,Shin-ichi Tashiro,Satoshi Onodera,Mingyu Xia,Takashi Ikejima. (2013-02-27) Pseudolaric acid B-induced autophagy contributes to senescence via enhancement of ROS generation and mitochondrial dysfunction in murine fibrosarcoma L929 cells.. Journal of pharmacological sciences, 121 ((3)): (200-211). [PMID:23439612] |
| 23. Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang. (2023) Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance. Bioactive Materials, 19 (1). [PMID:35415315] [10.1016/j.bioactmat.2021.12.018] |
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