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青霉素G钠

窄谱β-内酰胺类抗生素
41篇引用文献 COA COA
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P105489-5g
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P105489-25g
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P105489-100g
 100g 现货 Stock Image
P105489-500g
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Anti-infection (2804) Antibiotic (2632) Bacterial (5911) 青霉素抗生素 (7)
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基本描述

别名 苄基青霉素钠 | 青霉素钠 | 青霉素G钠盐 | 盘尼西林 G钠盐
英文别名 CHEBI:51765 | EN300-25914569 | PENICILLIN G, SODIUM SALT | BENZYLPENICILLIN SODIUM [MART.] | HY-B1463 | Penicillin G, sodium | 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-(2S,5R,6R)-, monosodium salt | C
规格或纯度 Moligand™, 1650 U/mg
英文名称 penicillin G，Na
生化机理 窄谱β-内酰胺类抗生素。与特定的青霉素结合蛋白结合。抑制细菌细胞壁的合成。在体内显示出对革兰氏阳性需氧生物的杀菌作用。
应用 抑制细菌细胞壁合成。 抗菌谱: 革兰氏阳性菌。
储存温度 2-8°C储存,充氩
运输条件 冰袋运输
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

溶于水,分解点为215℃，极易溶于水，溶于乙醇，不溶于脂肪油液体石蜡。有吸湿性，遇酸、碱、氧化剂、青霉素酶等均能使青霉素的β-内酰胺环打开而失效。 抑制细菌细胞壁合成。 抗菌谱: 革兰氏阳性菌。

application：

Penicillin G sodium salt is used as a β-lactam antibiotic. Penicillin G can be used as a selective agent in several types of isolation media. It has been used to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility and in cell culture both alone and combined with streptomycin and other antibiotics.

关联靶点（人）

CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

blaZ Beta-lactamase (285 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Streptococcus pneumoniae (31063 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ralstonia solanacearum (520 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Klebsiella pneumoniae (43867 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Staphylococcus aureus (210822 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Acinetobacter baumannii (41033 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Moraxella catarrhalis (3334 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Escherichia coli (133304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Haemophilus influenzae (8812 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus subtilis (32866 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus thuringiensis (718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Enterococcus faecalis (29875 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Bacillus cereus (7522 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Candida albicans (78123 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slc22a20 Solute carrier family 22 member 20 (86 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slc22a6 Solute carrier family 22 member 6 (141 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pectobacterium carotovorum (295 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

分子类型 小分子
IIUPAC Name sodium;(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
INCHI 1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
InChi Key FCPVYOBCFFNJFS-LQDWTQKMSA-M
Smiles CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[Na+]
Isomeric SMILES CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[Na+]
关联CAS 61-33-6
分子量 356.37
Reaxy-Rn 1038006
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1038006&ln=

化学和物理性质

溶解性 Soluble in water (100 mg/ml), alcohol, glycerol, DMSO (71 mg/ml at 25°C), and ethanol (< 1 mg/ml at 25°C).
敏感性 对空气敏感
比旋光度 [α]D 300° (C=2,H2O)
熔点 209-212°C
分子量 356.400 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 356.081 Da
单同位素质量Monoisotopic Mass 356.081 Da
拓扑极表面积Topological Polar Surface Area 115.000 Ų
重原子数Heavy Atom Count 24
形式电荷Formal Charge 0
复杂度Complexity 536.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 3
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 2

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H317: 可能引起皮肤过敏反应
预防措施声明

P233: 保持容器密闭。

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P272: 被污染的工作服不允许离开工作场所

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P302+P352: 如皮肤沾染：用水充分清洗。

P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P403+P235: 存放在通风良好的地方。保持低温。

P501: 将内容物/容器处理到。。。

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批号(Lot Number) 证书类型 货号
F2117202 分析证书 P105489
C2517351 分析证书 P105489
C2517353 分析证书 P105489
G2508593 分析证书 P105489
H2324347 分析证书 P105489
H2324646 分析证书 P105489
H2324688 分析证书 P105489
H2324742 分析证书 P105489
H2325006 分析证书 P105489
H2325013 分析证书 P105489
G2227277 分析证书 P105489
G2227278 分析证书 P105489
G2227279 分析证书 P105489
J2423103 分析证书 P105489
A2220316 分析证书 P105489
A2220321 分析证书 P105489
A2220322 分析证书 P105489
A2220339 分析证书 P105489

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此产品的引用文献

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引用文献

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15. Yujiao Tu, Suping Wang, Xiaotian Yuan, Pengfei Song, Yunlin Wei, Kunhao Qin, Qi Zhang, Xiuling Ji.  (2020)  Hydrothermal synthesis of Auricularia auricula derived nitrogen, phosphorus-doped carbon dots and application in Ag(I) and 4-nitrophenol detection and bioimaging.  Analytical Methods,  12  (17): (2237-2243).  [10.1039/D0AY00316F]
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22. Qu Fei, Sun Zhe, Liu Dongya, Zhao Xianen, You Jinmao.  (2016)  Direct and indirect fluorescent detection of tetracyclines using dually emitting carbon dots.  MICROCHIMICA ACTA,  183  (9): (2547-2553).  [10.1007/s00604-016-1901-9]
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24. Yueting Wu, Lele Tang, Linhong Huang, Zhizhong Han, Jian Wang, Haibo Pan.  (2014)  A low detection limit penicillin biosensor based on single graphene nanosheets preadsorbed with hematein/ionic liquids/penicillinase.  Materials Science & Engineering C-Materials for Biological Applications,  39  (92).  [PMID:24863203] [10.1016/j.msec.2014.02.012]
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27. Yin-Xia Sun, Bo-Tao Ji, Jiang-Hai Chen, Li-Ping Liu, Lu-Lu Gao, Zhe-Peng Deng, Yu Sun, Jian-Jun Wang, Biao Zhao, Jin-Guo Li.  (2025)  A smartphone-integrated bimetallic ratiometric fluorescent probe for specific visual detection of tetracycline antibiotics in food samples and latent fingerprinting.  FOOD CHEMISTRY,  464  (141782).  [PMID:39486281] [10.1016/j.foodchem.2024.141782]
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30. Li Kai, Yu Xuan, Xu Yanteng, Wang Haixia, Liu Zheng, Wu Chong, Luo Xing, Xu Jiancheng, Fang Youqiang, Ju Enguo, Lv Shixian, Chan Hon Fai, Lao Yeh-Hsing, He Weiling, Tao Yu, Li Mingqiang.  (2025)  Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers.  Nature Communications,  16  (1): (1-26).  [PMID:39952937] [10.1038/s41467-025-56407-7]
31. Zhenbin Chen, Haohan Cai, Feng Huang, Zongping Wang, Yiqun Chen, Zizheng Liu, Pengchao Xie.  (2024)  Degradation of β-lactam antibiotics by Fe(III)/HSO3− system and their quantitative structure-activity relationship.  ENVIRONMENTAL RESEARCH,  259  (119577).  [PMID:38986801] [10.1016/j.envres.2024.119577]
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33. Jingtao Wu, Yonghui Xia, Tianyu Wang, Yafeng Zhang, Guangli Li.  (2025)  Efficient voltammetric platform combining a molecularly imprinted polymer and silver-nanoparticle-decorated black phosphorus nanosheets for selective determination of Gatifloxacin.  Food Chemistry-X,  25  (102094).  [PMID:39758065] [10.1016/j.fochx.2024.102094]
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