| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| O408609-1ml |
1ml |
现货  |
|
| 英文别名 | Caryophyllin | (4aS,6aS,6bR,8aR,10S,12aR,12bR,14bS)-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Oleanolic Acid |
| 生化机理 | 齐墩果酸（Caryophyllin）是一种无毒的保肝三萜类化合物，存在于美洲商陆中，具有抗肿瘤和抗病毒的特性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
溶于甲醇、乙醇、乙醚、丙酮和氯仿，不溶于水。 Information Oleanolic Acid (Caryophyllin) is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana, which exerts antitumor and antiviral properties. Oleanolic Acid is a non-toxic, hepatoprotective triterpenoid found in Phytolacca Americana which exerts antitumor and antiviral properties. Oleanolic acid is effective in protecting against chemically induced liver injury in laboratory animals. Oleanolic acid are relatively non-toxic, and has been used in cosmetics and health products. Oleanolic acid was found to exhibit weak anti-HIV and weak anti-HCV activities, but more potent synthetic analogs are being investigated as potential drugs. In vivo
cell lines：MV4;11, MOLM13, NOMO1, RS4;11, HEL, HL60 and K562 Concentrations： Incubation Time： Powder Purity:≥95% |
| EC号 | 208-081-6 |
|---|---|
| 分子类型 | 小分子 |
| Isomeric SMILES | C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2CC=C4[C@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C(=O)O)C)C)(C)C)O |
| 分子量 | 456.7 |
| Beilstein号 | 10(4)1164 |
| Reaxy-Rn | 2228564 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2228564&ln= |
| 比旋光度 | 76 ° (C=1, CHCl3) |
|---|---|
| 熔点 | 300°C |
| WGK Germany | 2 |
|---|---|
| RTECS | RK0177965 |
| Merck Index | 6827 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
| 1. Lu Huang, Yingjie Guo, Tianqi Jin, Ke Yan, Xianglin Liu, Shuyang He, Lin Li, Ye Gong, Junyi Ma, Hang Yu, Zhoumin Lu, Yupeng Liu, Wuzi Dong, Fangxia Yang. (2023) Extraction of triterpene acids from loquat leaves via a novel hydrophobic deep eutectic solvent screened by COSMO-SAC model. Journal of Cleaner Production, 427 (139274). [10.1016/j.jclepro.2023.139274] |
| 2. Ying Wang, Xiaodan Wu, Guansong Shao, Bowen Zhai, Zihan Wang, Bingyang Qin, Tao Wang, Zhiguo Liu, Yujie Fu. (2024) Novel molecularly imprinted aerogels: Preparation, characterization, and application in selective separation for oleanolic acid in lingonberry. TALANTA, 266 (124983). [PMID:37542848] [10.1016/j.talanta.2023.124983] |
| 3. Luyao Ma, Fangjun Yu, Di He, Lianxia Guo, Yu Yang, Wangchun Li, Tianpeng Zhang. (2023) Role of circadian clock in the chronoefficacy and chronotoxicity of clopidogrel. BRITISH JOURNAL OF PHARMACOLOGY, [PMID:37403641] [10.1111/bph.16188] |
| 4. Qiang Lyu, Wanying Zheng, Qiyuan Shan, Lichuang Huang, Yiwen Wang, Lu Wang, Haodan Kuang, Muhammad Azam, Gang Cao. (2023) Expanding annotation of chemical compounds in hawthorn fruits and their variations in thermal processing using integrated mass spectral similarity networking. FOOD RESEARCH INTERNATIONAL, 172 (113114). [PMID:37689886] [10.1016/j.foodres.2023.113114] |
| 5. Man Ding, Xuechen Zhang, Jiangying Shi, Kaili Cui, Ruipeng Yang, Fengming Liu, Shuhua Shan, Ghani Israr, Zhuoyu Li. (2023) Terpenoids of quinoa bran suppresses colorectal cancer by inducing cell apoptosis. Food Bioscience, [10.1016/j.fbio.2023.102615] |
| 6. Qian-Wei Luo, Lu Yao, Ling Li, Zhuo Yang, Mei-Mei Zhao, Yong-Zhe Zheng, Fang-Fang Zhuo, Ting-Ting Liu, Xiao-Wen Zhang, Dan Liu, Peng-Fei Tu, Ke-Wu Zeng. (2022) Inherent Capability of Self-Assembling Nanostructures in Specific Proteasome Activation for Cancer Cell Pyroptosis. Small, 19 (9): (2205531). [PMID:36549896] [10.1002/smll.202205531] |
| 7. Mengdi Lv, Xiaoting Qian, Shijie Li, Jie Gong, Qun Wang, Yong Qian, Zhi Su, Xuling Xue, Hong-Ke Liu. (2023) Unlocking the potential of iridium and ruthenium arene complexes as anti-tumor and anti-metastasis chemotherapeutic agents. JOURNAL OF INORGANIC BIOCHEMISTRY, 238 (112057). [PMID:36370504] [10.1016/j.jinorgbio.2022.112057] |
| 8. Sunan Gao, Mingyi Yang, Zisheng Luo, Zhaojun Ban, Ya Pan, Mengyun Tu, Quan Ma, Xingyu Lin, Yanqun Xu, Li Li. (2022) Soy protein/chitosan-based microsphere as Stable Biocompatible Vehicles of Oleanolic Acid: An Emerging Alternative Enabling the Quality Maintenance of Minimally Processed Produce. FOOD HYDROCOLLOIDS, 124 (107325). [10.1016/j.foodhyd.2021.107325] |
| 9. Yanan Yan, Lin Li, Huilin Zhang, Fangfang Du, Yating Meng, Shaomin Shuang, Ruibing Wang, Shengmei Song, Chuan Dong. (2021) Carbon dots for ratiometric fluorescence detection of morin. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 256 (119751). [PMID:33819765] [10.1016/j.saa.2021.119751] |
| 10. Xiao-Kai Zhang, Qi-Wen Wang, Ya-Juan Xu, Hong-Mei Sun, Lei Wang, Li-Xin Zhang. (2021) Co-delivery of cisplatin and oleanolic acid by silica nanoparticles-enhanced apoptosis and reverse multidrug resistance in lung cancer. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 37 (6): (505-512). [PMID:33559348] [10.1002/kjm2.12365] |
| 11. Chaoyue Wang, Xiang Wang, Shanshan Zhao, Guanglei Zuo, Min Xu, Shengqiang Tong. (2020) Liquid chromatographic and liquid-liquid chromatographic separation of structural isomeric oleanolic acid and ursolic acid using hydroxypropyl-β-cyclodextrin as additive. JOURNAL OF CHROMATOGRAPHY A, 1625 (461332). [PMID:32709358] [10.1016/j.chroma.2020.461332] |
| 12. Yi Zhang, Jian Li, Zhen Wang, Ming-Ze Xu, Zhi Zeng, Jin-peng Huang, Yan-Qing Guan. (2020) Natural plant-derived polygalacturonic acid-oleanolic acid assemblies as oral-delivered nanomedicine for insulin resistance treatment. CHEMICAL ENGINEERING JOURNAL, 390 (124630). [10.1016/j.cej.2020.124630] |
| 13. Tenghe Zhang, Xinlu Li, Hang Song, Shun Yao. (2019) Ionic liquid-assisted catalysis for glycosidation of two triterpenoid sapogenins. NEW JOURNAL OF CHEMISTRY, 43 (43): (16881-16888). [10.1039/C9NJ04271G] |
| 14. Wang Hongmei, Zhang Ruili, Song Yangyang, Li Tianqi, Ge Ming. (2019) Protective Effect of Ganoderma Triterpenoids on Cadmium-Induced Testicular Toxicity in Chickens. BIOLOGICAL TRACE ELEMENT RESEARCH, 187 (1): (281-290). [PMID:29717433] [10.1007/s12011-018-1364-4] |
| 15. Huafang Ding, Xing Hu, Ximing Xu, Guowen Zhang, Deming Gong. (2018) Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on α-glucosidase. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 107 (1844). [PMID:29030193] [10.1016/j.ijbiomac.2017.10.040] |
| 16. Zeynep Tohtahon, Lu Zhang, Jianxin Han, Xing Xie, Zongcai Tu, Tao Yuan. (2017) Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits. JOURNAL OF FOOD BIOCHEMISTRY, 41 (4): (e12377). [10.1111/jfbc.12377] |
| 17. Yingxian Guan, Tong Zhao, Anrong Zhang, Di Zhang, Xiaoxiao Huang, Xiao Fang, Jiajun Geng, Jie Gang. (2024) A Potential Diabetic-Friendly Food Material: Optimization, Nutritional Quality, Structural Characteristics, and Functional Properties of Oat and Purple Potato Fermented by Ganoderma lucidum Mycelium. Fermentation-Basel, 10 (12): (618). [10.3390/fermentation10120618] |
| 18. Yujie Pan, Xiankang Xu, Weixue Zhao, Fang Tian, Yanrong Zhao, Tingting Zhang, Hui Yang, Jianzhong Han, Weilin Liu. (2025) Chitosan-polygalacturonic acid-double-layered liposomes for oleanolic acid delivery: In vitro semi-dynamic digestion, improved cell uptake and liver protection. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 308 (142534). [PMID:40147669] [10.1016/j.ijbiomac.2025.142534] |
| 19. Shenglu Liu, Haoxian Gou, Hui Wei, Shengdeng Chen, Shijie Zhuo, Ming Luo, Shu Qin, Mengyu Zhang, Jiatong Chen, Zhiwei Huang, Xianming Xia, Xiaoli Yang, Kai He. (2024) Cholecystohepatic shunt pathway reduces secondary bile acid accumulation to enhance natural killer T cell-mediated anti-hepatocellular carcinoma immunity. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, [PMID:38747068] [10.1111/jgh.16548] |
| 20. Shun Zhong, Yao Yao Qi, Yuan Yuan, Li Lian, Zeyuan Deng, Feng Pan, Junfu Zhou, Zhiyu Wang, Hongyan Li. (2024) Ganoderma lucidum spore powder after oil extraction alleviates microbiota dysbiosis to improve the intestinal barrier function in mice. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, [PMID:39243161] [10.1002/jsfa.13852] |
| 21. Xiangyan Mo, Fangxue Hang, Er-Fang Ren, Lili Gai, Kai Li, Debao Niu. (2025) Insight into the mechanism of efficient extraction of tea saponins from Camellia oleifera shells using deep eutectic solvents. Innovative Food Science & Emerging Technologies, 102 (104001). [10.1016/j.ifset.2025.104001] |
| 22. Tong Qingheng, Yao Weifeng. (2024) Integrated chemical characterization, metabolite profiling, and pharmacokinetics analysis of Zhijun Tangshen Decoction by UPLC-Q/TOF-MS. Frontiers in Pharmacology, 15 [PMID:38523634] [10.3389/fphar.2024.1363678] |
| 23. Guangjie Zhang, Huiying Zhang, Ruiyi Dong, Hongmei Zhao, Junfeng Li, Weiming Yue, Zheng Ma. (2024) Oleanolic acid attenuates obesity through modulating the lipid metabolism in high-fat diet-fed mice. Food Science & Nutrition, [PMID:39479652] [10.1002/fsn3.4408] |
| 24. Zeyan Gao, Fei Zha, Jiayi Zhang, Qiqi Zhong, Haifeng Tian, Xiaojun Guo. (2024) Simultaneous extraction of Saponin and Polysaccharide from Acanthopanax senticosus fruits with three-component Deep eutectic solvent and the extraction mechanism analysis. JOURNAL OF MOLECULAR LIQUIDS, 396 (123977). [10.1016/j.molliq.2024.123977] |
| 25. Zhiping Che, Ruiguang Wang, Yuanhao Li, Wanying Yin, Huilu Sun, Shaobin Xu, Shaoyan Shuang, Yuee Tian, Xiaobo Huang, Genqiang Chen. (2024) Synthesis, Anti-Oomycete and Anti-Fungal Activities of Anhydride Derivatives of Oleanolic Acid. CHEMISTRY & BIODIVERSITY, (e202401952). [PMID:39198232] [10.1002/cbdv.202401952] |
| 26. Hong Xiang, Yu Zhang, Jiaming Li, Li Li, Ziwei Li, Rui Ni, Dan Peng, Lining Jiang, Jianhong Chen, Yao Liu. (2025) Terminalia bellirica (Gaertn.) Roxb. Extracts reshape the perifollicular microenvironment and regulate the MAPK pathway for androgenetic alopecia treatment. JOURNAL OF ETHNOPHARMACOLOGY, 337 (118778). [PMID:39236776] [10.1016/j.jep.2024.118778] |
| 27. Hui-Bin Jiang, Pan Nie, Zi-Han Lin, Chuang Zhu, Ling-Yue Zhong, Fen-Fen Wei, Yan Wu, Li-Hua Song. (2024) The polyphenols profile of co-fermented quinoa and black barley with Lactobacillus kisonensis and its in vitro bioactivities. Food Bioscience, 58 (103712). [10.1016/j.fbio.2024.103712] |
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