| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| O407783-1ml |
1ml |
现货  |
|
| 英文别名 | 6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Omeprazole |
| 生化机理 | 奥美拉唑是一种质子泵抑制剂，可阻断 H(+)-K(+)-ATP 酶，用于治疗消化不良、消化性溃疡病、胃食管反流病、喉咽反流和卓-艾综合征。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | ATP4A 抑制剂；ClC-2 激活剂 |
| 产品介绍 |
Omeprazole is a benzimidazole derivative, a weak base and is lipophilic in nature. This compound is pH sensitive and does not exists in its original form at low pH. 用途 Omeprazole has been used as an atypical cytochrome P450 (CYP) 1A2 inducer in Dulbecco′s modified eagle′s medium (serum free) to study the effects of inducers on CYP activities in human hepatocytes and also to compare with other classical aryl hydrocarbon receptor ligands. Information Omeprazole Omeprazole is a proton pump inhibitor that blocks H(+)-K(+)-ATPase , used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome. Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect. In vivo
cell lines：HOS, HTB-186 Daoy, TC-71, RD, SK-N-AS, SK-N-DZ, LD and KCNR cells Concentrations： Incubation Time： Powder Purity:≥95% |
| Isomeric SMILES | CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC |
|---|---|
| 分子量 | 345.42 |
| Reaxy-Rn | 6489199 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6489199&ln= |
| 熔点 | 158-159°C |
|---|
| WGK Germany | 2 |
|---|---|
| RTECS | DD9087000 |
| Merck Index | 6845 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
| 1. Renhao Ni, Yang Luo, Lingjing Jiang, Xufeng Mao, Yuyao Feng, Subinuer Tuersun, Zeming Hu, Yabin Zhu. (2023) Repairing gastric ulcer with hyaluronic acid/extracellular matrix composite through promoting M2-type polarization of macrophages. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 245 (125556). [PMID:37364804] [10.1016/j.ijbiomac.2023.125556] |
| 2. Yanxia Liu, Wei Du, Xiuquan Yao, Chunlin Liu, Xiaofang Luo, Lei Guo, Chao Guo. (2022) Electrochemical and Theoretical Study of Corrosion Inhibition on X60 Steel in H2SO4 Solution by Omeprazole. International Journal of Electrochemical Science, 17 (220516). [10.20964/2022.04.58] |
| 3. Shasha Liu, Ruohan Cheng, Hui He, Kunming Ding, Rongmi Zhang, Yuanyuan Chai, Qinwei Yu, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2023) 8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 741 (109617). [PMID:37121295] [10.1016/j.abb.2023.109617] |
| 4. Jiang-Hong Luo, Wan-Shuang Zou, Jing Li, Wei Liu, Jing Huang, Hu-Wei Wu, Jian-Lin Shen, Fei Li, Jia-Shuang-Wei Yuan, An-Kang Tao, Liang Gong, Jun Zhang, Xiao-Yin Wang. (2023) Untargeted serum and liver metabolomics analyses reveal the gastroprotective effect of polysaccharide from Evodiae fructus on ethanol-induced gastric ulcer in mice. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 232 (123481). [PMID:36731690] [10.1016/j.ijbiomac.2023.123481] |
| 5. Jieqing Feng, Qisheng Zhong, Ting Zhou. (2022) Online Pressure Change Focusing-Supercritical Fluid Selective Extraction Chromatography for Analyzing Chiral Drugs in Microliter-Scale Plasma Samples. ANALYTICAL CHEMISTRY, 94 (46): (16222–16230). [PMID:36356211] [10.1021/acs.analchem.2c03892] |
| 6. Shiqi Duan, Yan Jia, Zhihang Zhu, Lancheng Wang, Peng Xu, Youmei Wang, Bin Di, Chi Hu. (2022) Induction of CYP450 by illicit drugs: Studies using an in vitro 3D spheroidal model in comparison to animals. TOXICOLOGY LETTERS, 367 (88). [PMID:35914676] [10.1016/j.toxlet.2022.07.815] |
| 7. Xiaoke Zheng, Hanyu Yang, Lan Qin, Siqian Wang, Lei Xie, Lu Yang, Weimin Kong, Liang Zhu, Li Liu, Xiaodong Liu. (2021) Bile Duct Ligation Upregulates Expression and Function of L-Amino Acid Transporter 1 at Blood–Brain Barrier of Rats via Activation of Aryl Hydrocarbon Receptor by Bilirubin. Biomedicines, 9 (10): (1320). [PMID:34680437] [10.3390/biomedicines9101320] |
| 8. Yuanyuan Chai, Yunxia Xu, Ziyin Xia, Xin Huang, Luyong Zhang, Zhenzhou Jiang. (2021) Study on the effects of Zhuanggu Guanjie Pill, a modern Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats. JOURNAL OF ETHNOPHARMACOLOGY, 281 (114521). [PMID:34390794] [10.1016/j.jep.2021.114521] |
| 9. Lu Zhao, Jie Liu, Yunfeng Bai, Feng Feng, Xiaoming Yang. (2021) Exploration of carbon dots derived from epimedium towards detecting dopamine and hydrogen peroxide. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 627 (127179). [10.1016/j.colsurfa.2021.127179] |
| 10. Liu Mingyang, Du Xuejun, Xu Ke, Yan Binwei, Fan Zaibi, Gao Zideng, Ren Xueqin. (2021) A cationic quantum dot-based ratiometric fluorescent probe to visually detect berberine hydrochloride in human blood serums. Journal of Analytical Science and Technology, 12 (1): (1-9). [10.1186/s40543-021-00261-x] |
| 11. Lu Wang, Yunfeng Chai, Wenquan Zhu, Yuanjiang Pan, Cuirong Sun, Su Zeng. (2017) Doubly charged trimeric cluster ions: effective in mutual chiral recognition of tadalafil and three proton pump inhibitors. ANALYST, 142 (5): (745-751). [PMID:28197557] [10.1039/C6AN02666D] |
| 12. Lili Wu, Wanping Zhong, Junjin Liu, Weichao Han, Shilong Zhong, Qiang Wei, Shuwen Liu, Lan Tang. (2015) Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat. FITOTERAPIA, 105 (26). [PMID:26045316] [10.1016/j.fitote.2015.05.021] |
| 13. Han-Ming Cui, Qiu-Yan Zhang, Jia-Long Wang, Jian-Long Chen, Yu-Ling Zhang, Xiao-Lin Tong. (2014) In vitro studies of berberine metabolism and its effect of enzyme induction on HepG2 cells. JOURNAL OF ETHNOPHARMACOLOGY, 158 (388). [PMID:25456436] [10.1016/j.jep.2014.10.018] |
| 14. Yan Xu, Weitao Yang, Zhuoyao Wu, Hui Wang, Tianming Cui, Weiwei Zeng, Yanjing Yun, Bingbo Zhang. (2024) A Chromium-Based magnetic resonance probe for in situ gastric pH imaging. CHEMICAL ENGINEERING JOURNAL, (154269). [10.1016/j.cej.2024.154269] |
| 15. Gu Lina, Sun Ying, Bai Tingjie, Shao Sijie, Tang Shumin, Xue Panpan, Cai Wanlin, Qin Xian, Zeng Xuemei, Yan Shuangqian. (2025) Functional nanozyme system for synergistic tumor immunotherapy via cuproptosis and ferroptosis activation. JOURNAL OF NANOBIOTECHNOLOGY, 23 (1): (1-20). [PMID:40089774] [10.1186/s12951-025-03284-3] |
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