基本描述

别名	橄榄苦甙
英文别名	methyl (2S,3E,4S)-4-{2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl}-3-ethylidene-2-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,4-dihydro-2H-pyran-5-carboxylate \| CCG-269961 \| CHEBI:7747 \| methyl (4S,5E,6S)-4-[2-[2-(3,4-dihydroxyph
规格或纯度	Moligand™, ≥98%
英文名称	Oleuropein
生化机理	研究表明，油菜素能微调大鼠去甲肾上腺素和肾上腺素的分泌。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
产品介绍	The primary phenolic compound found in olives and olive oil. Oleuropein hydrolyzes to form hydroxytyrosol and tyrosol, with hydroxytyrosol considered the main component associated with olive′s health benefits. Olive oil phenols demonstrate antioxidant, anti-thrombotic, anti-inflammatory and anti-atherogenic characteristics.橄榄苦苷的药理作用主要有降血压、抗氧化、抗微生物和抗癌等作用。 The primary phenolic compound found in olives and olive oil. Oleuropein hydrolyzes to form hydroxytyrosol and tyrosol, with hydroxytyrosol considered the main component associated with olive′s health benefits. Olive oil phenols demonstrate antioxidant, anti-thrombotic, anti-inflammatory and anti-atherogenic characteristics. An antioxidant and immunomodulator in vitro that is a tyrosol ester derivative of elenolic acid and phenolic glycoside found naturally olive oil.
纯度	≥98%

关联靶点（人）

TAS2R8 Tchem 2 型味觉受体成员 8(Taste receptor type 2 member 8) (0 活性数据)

点击查看靶蛋白信息： TAS2R8

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 活性数据)

点击查看靶蛋白信息： ALOX5

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HL-60 (67320 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

K562 (73714 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SK-BR-3 (5175 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

HeLa (62764 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

PBMC (10003 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

关联靶点（其它种属）

Hdac6 Histone deacetylase 6 (222 活性数据)

点击查看靶蛋白信息： Hdac6

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

Verticillium dahliae (119 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

B16-F1 (104 活性数据)

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活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 活性数据)

点击查看此靶标相关信息

活性类型	Relation	Activity value	Units	Action Type	期刊	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

EC号	251-129-6
分子类型	小分子
IIUPAC Name	methyl (4S,5E,6S)-4-[2-[2-(3,4-dihydroxyphenyl)ethoxy]-2-oxoethyl]-5-ethylidene-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4H-pyran-3-carboxylate
INCHI	1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3/b13-3+/t14-,18+,20+,21-,22+,24-,25-/m0/s1
InChi Key	RFWGABANNQMHMZ-ZCHJGGQASA-N
Smiles	CC=C1C(C(=COC1OC2C(C(C(C(O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O
Isomeric SMILES	C/C=C/1\[C@@H](C(=CO[C@H]1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)C(=O)OC)CC(=O)OCCC3=CC(=C(C=C3)O)O
分子量	540.51
Reaxy-Rn	26520590
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26520590&ln=

化学和物理性质

溶解性	Soluble in water, acetone, ethanol, pyridine, glacial acetic acid , 5% aq NaOH, dioxane, butano, ethyl acetate, butyl acetate, DMF (50 mg/ml), and methanol. Insoluble in ether, chloroform, petr ether, benzene, and carbon tetrachloride.
密度	1.5
敏感性	易吸潮
比旋光度	-165° (C=0.5,EtOH)
熔点	89 °C
分子量	540.500 g/mol
XLogP3	-0.400
氢键供体数Hydrogen Bond Donor Count	6
氢键受体数Hydrogen Bond Acceptor Count	13
可旋转键计数Rotatable Bond Count	11
精确质量Exact Mass	540.184 Da
单同位素质量Monoisotopic Mass	540.184 Da
拓扑极表面积Topological Polar Surface Area	202.000 Å²
重原子数Heavy Atom Count	38
形式电荷Formal Charge	0
复杂度Complexity	873.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	7
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	1
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	1
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

预防措施声明	P264: 处理后要彻底洗手。
WGK Germany	3
Merck Index	6830
个人防护装备	Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

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找到13个结果

批号(Lot Number)	证书类型	货号
J2510102	分析证书	O140217
C2524416	分析证书	O140217
C2524417	分析证书	O140217
C2524418	分析证书	O140217
C2524419	分析证书	O140217
C2524420	分析证书	O140217
C2524421	分析证书	O140217
I2411369	分析证书	O140217
L2315523	分析证书	O140217
L2315524	分析证书	O140217
K2316080	分析证书	O140217
G23151131	分析证书	O140217
J2213947	分析证书	O140217

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引用文献

1. Shuyan Han, Hongmei Hou, Yiren Zhang, Zhongxiang Fang, Yun Li, Le Zhang, Yandan Wang, Shijia Zhang, Hui Zhang, Qingzhe Jin, Gangcheng Wu, Xingguo Wang. (2023) Oleuropein and its hydrolysate from extra virgin olive oil inhibit breast cancer cells proliferation interfering with the PI3K-AKT signal pathway. Journal of Functional Foods, 110 (105880). [10.1016/j.jff.2023.105880]
2. Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding. (2021) Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in Caenorhabditis elegans. Antioxidants, 10 (11): (1697). [PMID:34829568] [10.3390/antiox10111697]
3. Yanfang Wu, Yindi Chu, Qinyu Yang, Mengjia Li, Miao Yu, Ruixue Deng, Kun Liu, Xinsheng Wang, Enguo Fan. (2021) Response surface methodology optimised solvothermal system enables an efficient extraction of echinacoside and oleuropein from Syringa pubescens Turcz. PHYTOCHEMICAL ANALYSIS, 32 (6): (1074-1081). [PMID:33837595] [10.1002/pca.3049]
4. Xinsheng Wang, Yanfang Wu, Jie Li, Aoxiang Wang, Guangyao Li, Xueli Ren, Weiping Yin. (2020) Ultrasound-assisted deep eutectic solvent extraction of echinacoside and oleuropein from Syringa pubescens Turcz.. INDUSTRIAL CROPS AND PRODUCTS, 151 (112442). [10.1016/j.indcrop.2020.112442]
5. Dongli Li, Xiaodan Tang, Chang Liu, Huifang Li, Shuzhen Li, Shili Sun, Xi Zheng, Panpan Wu, Xuetao Xu, Kun Zhang, Hang Ma. (2020) Jasmine (Jasminum grandiflorum) Flower Extracts Ameliorate Tetradecanoylphorbol Acetate Induced Ear Edema in Mice. Natural Product Communications, [10.1177/1934578X20917498]
6. Lingyi Liu, Zhou Jin, Min Wang, Wangyang Shen, Zhenzhou Zhu, Zhan Wang, Lianliang Liu. (2018) W/O Nano-Emulsions with Olive Leaf Phenolics Improved Oxidative Stability of Sacha Inchi Oil. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 120 (5): (1700471). [10.1002/ejlt.201700471]
7. Zhihong Wang, Chengzhang Wang, Changwei Zhang, Wenjun Li. (2017) Ultrasound-assisted enzyme catalyzed hydrolysis of olive waste and recovery of antioxidant phenolic compounds. Innovative Food Science & Emerging Technologies, 44 (224). [10.1016/j.ifset.2017.02.013]
8. Wu Zun-Qiu, Yue Gui-Zhou, Zhu Qing-Ping, Jiang You-Jun, Tang Kai-Yu, Chen Hua-Ping, Yang Ze-Shen, Huang Qian-Ming. (2015) Purification, Dynamic Changes and Antioxidant Activities of Oleuropein in Olive (Olea Europaea L.) Leaves. JOURNAL OF FOOD BIOCHEMISTRY, 39 (5): (566-574). [10.1111/jfbc.12152]
9. Yueping You, Yi Wang, Meiyi Liang, Chenglin Wu, Zhiheng Huang, Jinlin Guo, Hulan Chen, Yu Fan. (2025) The Pd nanoparticles-modified porphyrin metal-organic framework as highly efficient oxidase mimics for colorimetric quantification and discrimination of oleuropein. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 710 (136236). [10.1016/j.colsurfa.2025.136236]

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货号 (SKU)	包装规格	是否现货
O140217-10mg	10mg	现货
O140217-25mg	25mg	现货
O140217-50mg	50mg	现货
O140217-100mg	100mg	期货

橄榄苦苷

库存信息

库存信息

库存信息

库存信息

基本描述

关联靶点（人）

关联靶点（其它种属）

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

显示更多⌵

此产品的引用文献

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器