| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| O126646-10mg |
10mg |
现货  |
| |
| O126646-50mg |
50mg |
现货 |
|
| 英文别名 | Oseltamivir (INN) | AKOS015843442 | Tamiflu (*Phosphate salt 1:1*) | VSZGPKBBMSAYNT-RRFJBIMHSA-N | 20O93L6F9H | NCGC00095191-16 | BRD-K76011241-045-01-5 | NCGC00178698-02 | (3R,4R,5S)-4-acetylamino-5-amino-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid |
|---|---|
| 规格或纯度 | Moligand™, ≥98% |
| 英文名称 | Oseltamivir |
| 生化机理 | 奥司他韦（GS 4104；GOP-A-Flu；GS 4104；Tamiflu-Free；Tamvir）是一种抗病毒药物。GS 4104；GOP-A-Flu；GS 4104；Tamiflu-Free；Tamvir 通过阻止病毒与宿主细胞的化学联系，从而减缓流感病毒在人体细胞间的传播；症状缓解的中位时间缩短了 0.5-1 天。GS 4104；GOP-A-Flu；GS 4104；Tamiflu-Free；Tamvir 在市场上的商品名为 "特敏福"，以胶囊或混悬液形式口服。自 1999 年以来，它已被用于治疗和预防 5000 多万人感染甲型流感病毒和乙型流感病毒。奥司他韦（GS 4104；GOP-A-Flu；GS 4104；Tamiflu-Free；Tamvir）适用于抗病毒药物 |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504753942 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate |
| INCHI | 1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1 |
| InChi Key | VSZGPKBBMSAYNT-RRFJBIMHSA-N |
| Smiles | CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC |
| Isomeric SMILES | CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OCC |
| 分子量 | 312.4 |
| Reaxy-Rn | 25082342 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25082342&ln= |
| 溶解性 | DMSO |
|---|---|
| 分子量 | 312.400 g/mol |
| XLogP3 | 1.100 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 8 |
| 精确质量Exact Mass | 312.205 Da |
| 单同位素质量Monoisotopic Mass | 312.205 Da |
| 拓扑极表面积Topological Polar Surface Area | 90.700 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 418.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 3 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 1. Hata K, Koseki K, Yamaguchi K, Moriya S, Suzuki Y, Yingsakmongkon S, Hirai G, Sodeoka M, von Itzstein M, Miyagi T. (2008) Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.. Antimicrob Agents Chemother, 52 (10): (3484-91). [PMID:18694948] |
| 2. Richards MR, Guo T, Hunter CD, Cairo CW. (2018) Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity.. Bioorg Med Chem, 26 (19): (5349-5358). [PMID:29903413] |
| 3. Hou B, Liu Z, Yang XB, Zhu WF, Li JY, Yang L, Reng FC, Lv YF, Hu JM, Liao GY et al.. (2019) Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases.. Bioorg Med Chem, 27 (17): (3846-3852). [PMID:31324565] |
| 4. Xiaojiang Wang, Yukun Jiao, Haiyan Zhu, Yan Lu, Daofeng Chen. (2023) Exploring the anticomplement components from Fagopyrum dibotrys for the treatment of H1N1-induced acute lung injury by UPLC-Triple-TOF-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 223 (115158). [PMID:36410130] [10.1016/j.jpba.2022.115158] |
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| 6. Jianyu Zhu, Qiang Li, Xuezhi Yu, Xiya Zhang, Hongfang Li, Kai Wen, Yuebin Ke, Suxia Zhang, Zhanhui Wang. (2021) Synthesis of hapten, production of monoclonal antibody, and development of immunoassay for ribavirin detection in chicken. JOURNAL OF FOOD SCIENCE, 86 (7): (2851-2860). [PMID:34146404] [10.1111/1750-3841.15789] |
| 7. Dai Tianming, Wang Min, Wang Pengzhen, Dai Libing, Dai Renke, Meng Qingqi. (2021) Inhibition effects of eight anti-coronavirus drugs on glycosides metabolism and glycosidases in human gut microflora. PHARMAZIE, 76 (5): (195-201). [PMID:33964992] [10.1691/ph.2021.01005] |
| 8. Zhaopeng Wang, Xuezhi Yu, Licai Ma, Hebing Liu, Shuangyang Ding, Zhanhui Wang, Xiya Zhang, Jianzhong Shen, Kai Wen. (2018) Preparation of high affinity antibody for ribavirin with new haptens and residue analysis in chicken muscle, eggs and duck muscle. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, 35 (7): (1247-1256). [PMID:29578378] [10.1080/19440049.2018.1447693] |
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