| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N424310-1ml |
1ml |
现货  |
|
| 别名 | 马索罗酚 | 1,4-双(3,4-二羟苯基)-2,3-二甲基丁烷, 4,4'-(2,3-二甲基四亚甲基)二邻苯二酚 |
|---|---|
| 英文别名 | NDGA | AC-24202 | HMS503G19 | Z2065671207 | 1, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis- | KBio2_004917 | KBio3_002828 | KBioSS_001626 | 4,4'-(2,3-dimethylbutane-1,4-diyl)bis(benzene-1,2-diol) | NCGC00015741-09 | MLS000069451 | NCGC00015741-04 | nordihydrogu |
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Nordihydroguaiaretic Acid |
| 生化机理 | 脂氧合酶抑制剂；含多酚的邻二羟基（儿茶酚）结构。天然有效的抗氧化剂。体内外多种药理作用。抗癌，抗微生物，抗炎和免疫抑制活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
产品介绍 Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS) 用途 Nordihydroguaiaretic acid can be used: In the synthesis of nordihydroguaiaretic acid derivatives with potent HIV inhibition activity；As a starting material in the synthesis of tetra-O-methylnordihydroguaiaretic acid. Product Introduction Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS) Application Nordihydroguaiaretic acid can be used: In the synthesis of nordihydroguaiaretic acid derivatives with potent HIV inhibition activity；As a starting material in the synthesis of tetra-O-methylnordihydroguaiaretic acid. |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol |
| INCHI | 1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 |
| InChi Key | HCZKYJDFEPMADG-UHFFFAOYSA-N |
| Smiles | CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O |
| Isomeric SMILES | CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O |
| 分子量 | 302.37 |
| Beilstein号 | 6(1)577 |
| Reaxy-Rn | 9803564 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9803564&ln= |
| 熔点 | 184-188℃ |
|---|---|
| 分子量 | 302.400 g/mol |
| XLogP3 | 4.300 |
| 氢键供体数Hydrogen Bond Donor Count | 4 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 302.152 Da |
| 单同位素质量Monoisotopic Mass | 302.152 Da |
| 拓扑极表面积Topological Polar Surface Area | 80.900 Ų |
| 重原子数Heavy Atom Count | 22 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 303.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 2 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P330: 漱口 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| RTECS | UX1750000 |
| Merck Index | 6693 |
| 个人防护装备 | dust mask type N95 (US)， Eyeshields， Gloves |
| 1. Bin Wang, Xin-Li Xu, Man-Yu Zhang, Xin-Miao Bu, Hong-Lei Wang, Xue-Zhong Shi, Xia Xu, Di Chen. (2023) A fully green sample preparation method for synthetic antioxidants determination in edible oils based on natural feather fiber-supported liquid extraction. JOURNAL OF CHROMATOGRAPHY A, 1698 (464004). [PMID:37094539] [10.1016/j.chroma.2023.464004] |
| 2. Jinhua Zhu, Danyang Zhou, Dandan Wu, Wei Liu, Xiuhua Liu. (2022) TiO2 nanotube immobilised 5-lipoxygenase-mediated screening and isolation of anti-inflammatory active compounds from the leaves of lonicera japonica thunb. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 37 (1): (2540-2550). [PMID:36120953] [10.1080/14756366.2022.2121392] |
| 3. Yuling Li, Xiaotong Wu, Zixuan Wu, Mingmin Zhong, Xiaoping Su, Youai Ye, Yan Liu, Lei Tan, Yong Liang. (2022) Colorimetric sensor array based on CoOOH nanoflakes for rapid discrimination of antioxidants in food. Analytical Methods, 14 (28): (2754-2760). [PMID:35781305] [10.1039/D2AY00692H] |
| 4. Han Xueyuan, Wang Xiaoyu, Shen Chi, Mo Yiwei, Tian Rungang, Mao Linchun, Luo Zisheng, Yang Huanyi. (2022) Exogenous ABA promotes aroma biosynthesis of postharvest kiwifruit after low-temperature storage. PLANTA, 255 (4): (1-13). [PMID:35257207] [10.1007/s00425-022-03855-w] |
| 5. Xue Cheng, Guan Si-Cong, Chen Jian-Qing, Wen Chen-Jin, Cai Jian-Fa, Chen Xu. (2020) Genome wide identification and functional characterization of strawberry pectin methylesterases related to fruit softening. BMC PLANT BIOLOGY, 20 (1): (1-17). [PMID:31914938] [10.1186/s12870-019-2225-9] |
| 6. Shi Yuru, Zhang Xiaoqian, Pei Shengji, Wang Yuhua. (2024) Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway. Natural Products and Bioprospecting, 14 (1): (1-12). [PMID:38833115] [10.1007/s13659-024-00458-8] |
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