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N-乙酰神经氨酸
有货
库存信息
| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N421219-1ml |
1ml |
现货  |
|
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基本描述
| 别名 | NAN | NANA | 唾液酸 | 醋纽拉酸 | N-乙酰甘露糖胺丙酮酸 | 5-乙酰氨基-3,5-双脱氧-D-丙三基-D-半乳糖唾液酸 | N-(-)-乙酰甘露糖胺丙酮酸 |
|---|---|
| 英文别名 | 131-48-6 | N-acetyl-beta-neuraminic acid | N-acetylneuramic acid | N-Acetyl-D-neuraminic acid | Lactaminic acid | NANA | 5-N-ACETYL-BETA-D-NEURAMINIC ACID | beta-Neu5Ac | BETA-SIALIC ACID | (2S,4S,5R,6R)-5-Acetamido-2,4-dihydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydr |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | N-Acetylneuraminic acid |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
比旋光度-32° (c=2,water)。水溶性50 g/L (20℃)。溶于水，微溶于乙醇，不溶于乙醚。 |
关联靶点（人）
NEU2
Tbio
Sialidase 2
(382 活性数据)
NEU3
Tchem
Sialidase 3
(398 活性数据)
NEU4
Tchem
Sialidase 4
(267 活性数据)
NEU1
Tchem
Sialidase 1
(236 活性数据)
CBX1
Tbio
Chromobox protein homolog 1
(92434 活性数据)
KPNB1
Tbio
Importin subunit beta-1/Snurportin-1
(25097 活性数据)
关联靶点（其它种属）
NA
Neuraminidase (1107 活性数据)
Hdac6
Histone deacetylase 6 (222 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
名称和识别符
| EC号 | 205-023-1 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid |
| INCHI | 1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11-/m0/s1 |
| InChi Key | SQVRNKJHWKZAKO-PFQGKNLYSA-N |
| Smiles | CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O |
| Isomeric SMILES | CC(=O)N[C@@H]1[C@H](C[C@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)O)O)O |
| 分子量 | 309.27 |
| Beilstein号 | 1716283 |
| Reaxy-Rn | 2339228 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2339228&ln= |
化学和物理性质
| 敏感性 | 对湿度&空气& 热敏感 |
|---|---|
| 比旋光度 | -32 ° (C=1, H2O) |
| 熔点 | 192-194°C |
| 分子量 | 309.270 g/mol |
| XLogP3 | -3.500 |
| 氢键供体数Hydrogen Bond Donor Count | 7 |
| 氢键受体数Hydrogen Bond Acceptor Count | 9 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 309.106 Da |
| 单同位素质量Monoisotopic Mass | 309.106 Da |
| 拓扑极表面积Topological Polar Surface Area | 177.000 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 403.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 6 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
安全和危险性（GHS）
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H319: 引起严重眼睛刺激 |
| 预防措施声明 |
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| WGK Germany | 3 |
| Merck Index | 8484 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
引用文献
| 1. Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu, Yongzhong Du. (2023) Sialic Acid-Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy. Small, (2306905). [PMID:37880861] [10.1002/smll.202306905] |
| 2. Guan Hanxiao, Xie Chen, Cao Yuqi, Huang Pingjie, Hou Dibo, Zhang Guangxin. (2023) Qualitative Identification of Sialic Acid Content Based on Terahertz Time-Domain Spectroscopy. Journal of Infrared Millimeter and Terahertz Waves, 44 (9): (780-794). [10.1007/s10762-023-00939-w] |
| 3. Li Huixin, Xu Yanpeng, Wang Yang, Cui Yihao, Lin Jiake, Zhou Yuemin, Tang Shuling, Zhang Ying, Hao Haibin, Nie Zihao, Wang Xiaoyu, Tang Ruikang. (2023) Material-engineered bioartificial microorganisms enabling efficient scavenging of waterborne viruses. Nature Communications, 14 (1): (1-13). [PMID:37537158] [10.1038/s41467-023-40397-5] |
| 4. Shiwei Liu, Shuang Han, Yuzhuo Song, Ruonan Sun, Le Zhao, Chen Yan. (2023) Disulfide-Bridged Dendritic Organosilicas-Based Biodegradable Molecularly Imprinted Polymers for Multiple Targeting and pH/Redox-Responsive Drug Release toward Chemical/Photodynamic Synergistic Tumor Therapy. Advanced Healthcare Materials, 12 (20): (2300184). [PMID:36943098] [10.1002/adhm.202300184] |
| 5. Liu Quanzhen, Wei Guoguang, Yang Pengfan, Wang Chengyong, Chen Kequan, Ouyang Pingkai, Zhang Alei. (2023) One-pot biosynthesis of N-acetylneuraminic acid from chitin via combination of chitin-degrading enzymes, N-acetylglucosamine-2-epimerase, and N-neuraminic acid aldolase. Frontiers in Microbiology, 14 [PMID:37025634] [10.3389/fmicb.2023.1156924] |
| 6. Huihui Yang, Xiaosen Bai, Baolong Feng, Qinghua Wang, Li Meng, Fengzhong Wang, Yutang Wang. (2023) Application of Molecular Transformer approach for predicting the potential reactions to generate advanced glycation end products in infant formula. FOOD CHEMISTRY, 407 (135143). [PMID:36516683] [10.1016/j.foodchem.2022.135143] |
| 7. Rufeng Zhu, Yuedan Wang, Yang Tao, Yao Wang, Yuanli Chen, Mufang Li, Qiongzhen Liu, Liyan Yang, Dong Wang. (2022) Layer-by-layer assembly of composite conductive fiber-based organic electrochemical transistor for highly sensitive detection of sialic acid. ELECTROCHIMICA ACTA, 425 (140716). [10.1016/j.electacta.2022.140716] |
| 8. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen. (2022) N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 211 (259). [PMID:35513096] [10.1016/j.ijbiomac.2022.04.180] |
| 9. Shuang Han, Yuzhuo Song, Shiwei Liu, Le Zhao, Ruonan Sun. (2022) Dual responsive molecularly imprinted polymers based on UiO-66-DOX for selective targeting tumor cells and controlled drug release. EUROPEAN POLYMER JOURNAL, 171 (111219). [10.1016/j.eurpolymj.2022.111219] |
| 10. Zeng Jiaxin, Meng Yuan, Chen Shi-Yi, Zhao Gaofeng, Wang Lianchun, Zhang En-Xin, Qiu Hong. (2022) Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin. GLYCOCONJUGATE JOURNAL, 39 (3): (315-325). [PMID:34699015] [10.1007/s10719-021-10018-8] |
| 11. Zhang Xin, Wang Chen, Han Qing, Chen Xuan, Li Guoyun, Yu Guangli. (2021) Highly sialylated mucin-type glycopeptide from porcine intestinal mucosa after heparin extraction: O-glycan profiling and immunological activity evaluation. GLYCOCONJUGATE JOURNAL, 38 (5): (527-537). [PMID:34480673] [10.1007/s10719-021-10014-y] |
| 12. Xi Lin, Chunsheng Xiao, Ling Ling, Liming Guo, Xinhua Guo. (2021) A dual-mode reactive matrix for sensitive and quantitative analysis of carbohydrates by MALDI-TOF MS. TALANTA, 235 (122792). [PMID:34517650] [10.1016/j.talanta.2021.122792] |
| 13. Junyang Chen, Shan Jiang, Mengke Wang, Xiaolei Xie, Xingguang Su. (2021) Self-assembled dual-emissive nanoprobe with metal−organic frameworks as scaffolds for enhanced ascorbic acid and ascorbate oxidase sensing. SENSORS AND ACTUATORS B-CHEMICAL, 339 (129910). [10.1016/j.snb.2021.129910] |
| 14. Fan Kai, Lu Chengying, Shu Gaofeng, Lv Xiu-Ling, Qiao Enqi, Zhang Nannan, Chen Minjiang, Song Jingjing, Wu Fazong, Zhao Zhongwei, Xu Xiaoling, Xu Min, Chen Chunmiao, Yang Weibin, Sun Jihong, Du Yongzhong, Ji Jiansong. (2021) Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC. JOURNAL OF NANOBIOTECHNOLOGY, 19 (1): (1-17). [PMID:33731140] [10.1186/s12951-021-00821-8] |
| 15. Feiyang Jin, Jing Qi, Minxia Zhu, Di Liu, Yuchan You, Gaofeng Shu, Yan Du, Jun Wang, Hui Yu, Mingchen Sun, Xiaoling Xu, Qiying Shen, Xiaoying Ying, Jiansong Ji, Yongzhong Du. (2020) NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity. ACS Applied Materials & Interfaces, 12 (29): (32372–32387). [PMID:32597641] [10.1021/acsami.0c07503] |
| 16. Nian Cao, Faqiong Zhao, Baizhao Zeng. (2020) A novel ratiometric molecularly imprinted electrochemiluminescence sensor for sensitive and selective detection of sialic acid based on PEI-CdS quantum dots as anodic coreactant and cathodic luminophore. SENSORS AND ACTUATORS B-CHEMICAL, 313 (128042). [10.1016/j.snb.2020.128042] |
| 17. Jinmin Wang, Limin Zhao, Bing Yan. (2020) Indicator Displacement Assay Inside Dye-Functionalized Covalent Organic Frameworks for Ultrasensitive Monitoring of Sialic Acid, an Ovarian Cancer Biomarker. ACS Applied Materials & Interfaces, 12 (11): (12990–12997). [PMID:32106673] [10.1021/acsami.0c00101] |
| 18. Xiang-Nan He, Ya-Ning Wang, Yue Wang, Zhang-Run Xu. (2020) Accurate quantitative detection of cell surface sialic acids with a background-free SERS probe. TALANTA, 209 (120579). [PMID:31892066] [10.1016/j.talanta.2019.120579] |
| 19. Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du, Jian-Song Ji. (2019) Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles. BIOMATERIALS, 217 (119326). [PMID:31288173] [10.1016/j.biomaterials.2019.119326] |
| 20. Shaomei Xu, Songtian Che, Pinyi Ma, Fangmei Zhang, Longbin Xu, Xin Liu, Xinghua Wang, Daqian Song, Ying Sun. (2019) One-step fabrication of boronic-acid-functionalized carbon dots for the detection of sialic acid. TALANTA, 197 (548). [PMID:30771974] [10.1016/j.talanta.2019.01.074] |
| 21. Feiyang Jin, Di Liu, Hui Yu, Jing Qi, Yuchan You, Xiaoling Xu, Xuqi Kang, Xiaojuan Wang, Kongjun Lu, Xiaoying Ying, Jian You, Yongzhong Du, Jiansong Ji. (2019) Sialic Acid-Functionalized PEG–PLGA Microspheres Loading Mitochondrial-Targeting-Modified Curcumin for Acute Lung Injury Therapy. MOLECULAR PHARMACEUTICS, 16 (1): (71–85). [PMID:30431285] [10.1021/acs.molpharmaceut.8b00861] |
| 22. Jing-Bo Hu, Di Liu, Jing Qi, Kong-jun Lu, Fei-yang Jin, Xiao-Ying Ying, Jian You, Yong-Zhong Du. (2018) An E-selectin targeting and MMP-2-responsive dextran–curcumin polymeric prodrug for targeted therapy of acute kidney injury. Biomaterials Science, 6 (12): (3397-3409). [PMID:30371703] [10.1039/C8BM00813B] |
| 23. Lingbo Sun, Hongxia Fu, Yanru Li, Xinrui Duan, Zhengping Li. (2016) Rapid Recognition and Isolation of Live Colon Cancer Stem Cells by Using Metabolic Labeling of Azido Sugar and Magnetic Beads. ANALYTICAL CHEMISTRY, 88 (7): (3953–3958). [PMID:26937691] [10.1021/acs.analchem.6b00154] |
| 24. Tiantian Yin, Licong Yang, Yanan Liu, Xianbo Zhou, Jing Sun, Jie Liu. (2015) Sialic acid (SA)-modified selenium nanoparticles coated with a high blood–brain barrier permeability peptide-B6 peptide for potential use in Alzheimer’s disease. Acta Biomaterialia, 25 (172). [PMID:26143603] [10.1016/j.actbio.2015.06.035] |
| 25. Qianyun Fu,Guoyun Li,Chen Wang,Ya Wang,Qinying Li,Jiejie Hao,Guangli Yu. (2019-04-10) Profiling and Structural Characterization of High Neu5Gc or Sulfate-containing O-glycans from Hyla Rabbit Intestinal Mucin.. Molecules (Basel, Switzerland), 24 ((7)): [PMID:30959980] |
| 26. Xinlv Peng, Caixia Pei, Eika W. Qian, Yuguang Du, Jian-Jun Li. (2024) Co-immobilization of a bi-enzymatic cascade into hierarchically porous MIL-53 for efficient 6′-sialyllactose production. Nanoscale, [PMID:39046038] [10.1039/D4NR01775G] |
| 27. Juncheng Liu, Xingyu Lu, Fang Fang, Kaizhang Wu, Jihong Wu, Jie Gao. (2024) Comparison of the in-vitro effect of five prebiotics with different structure on gut microbiome and metabolome. Food Bioscience, (103810). [10.1016/j.fbio.2024.103810] |
| 28. Sun Yunze, Mi Zhuang, Chen Xiaoyu, Li Jian-Jun, Lu Jun, Shan Xinyan, Lu Xinghua, Du Yuguang. (2024) Identification of nine mammal monosaccharides by solid-state nanopores. Scientific Reports, 14 (1): (1-9). [PMID:39738399] [10.1038/s41598-024-83690-z] |
| 29. Liang Shuyu, Tang Qi, Guo Xunzi, Li Zi’an, Guo Yilan, Chang Jinghan, Cheng Bo, Song Qitao, Sun Jiayu, Dai Peng, Chen Xing. (2025) Mutant glycosidases for labeling sialoglycans with high specificity and affinity. Nature Communications, 16 (1): (1-14). [PMID:39915445] [10.1038/s41467-025-56629-9] |
| 30. Liu Zhaohong, Xiang Peng, Zeng Shengmei, Weng Ping, Wen Yilin, Zhang Wanping, Hu Hui, Zhao Dezhang, Ma Limei, Yu Chao. (2024) N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathway. Cell Death Discovery, 10 (1): (1-16). [PMID:39537619] [10.1038/s41420-024-02233-7] |
| 31. Yuzhen Zhao, Mingge Li, Yue Guo, Jian Jin, Fei Pei, Wenya Wang, Changhua Liu, Wenyan Yu, Jinjin Shi, Na Yin. (2024) Neutrophil hitchhiking nanoparticles enhance bacteria-mediated cancer therapy via NETosis reprogramming. JOURNAL OF CONTROLLED RELEASE, 367 (661). [PMID:38301928] [10.1016/j.jconrel.2024.01.068] |
| 32. Xiangyu Meng, Chen Xv, Jiaping Lv, Shuwen Zhang, Changlu Ma, Xiaoyang Pang. (2024) Optimizing Akkermansia muciniphila Isolation and Cultivation: Insights into Gut Microbiota Composition and Potential Growth Promoters in a Chinese Cohort. Microorganisms, 12 (5): (881). [PMID:38792711] [10.3390/microorganisms12050881] |
| 33. Su Fang, Jianrong Wu, Wenxuan Niu, Tiantian Zhang, Tiantian Hong, Hongtao Zhang, Xiaobei Zhan. (2024) Sialylation of dietary mucin modulate its digestibility and the gut microbiota of elderly individuals. FOOD RESEARCH INTERNATIONAL, 184 (114246). [PMID:38609225] [10.1016/j.foodres.2024.114246] |
| 34. Zhenjun Wang, Zongtao Xie, Chuanxin Liu, Xiaojun Zhang. (2024) Synergistic chemotherapy and photothermal therapy of lung cancer using MoS2 nanosheets co-loaded with silybin and doxorubicin. Alexandria Engineering Journal, 106 (767). [10.1016/j.aej.2024.09.033] |
| 35. SunHongzheng , HanLongsen , GuoYueshuai , AnHuiqing , WangBing , ZhangXiangzheng , LiJiashuo , JiangYingtong , WangYue , SunGuangyi , ZhuShuai , TangShoubin , GeJuan , ChenMinjian , GuoXuejiang , WangQiang. (2024) The global phosphorylation landscape of mouse oocytes during meiotic maturation. EMBO JOURNAL, [PMID:39256562] [10.1038/s44318-024-00222-1] |
| 36. Zihan Zhu, Yan Zhang, Cui He, Yimin Jin, Wei Bian, Xinjing Tang, Jing Wang. (2025) Tumor microenvironment-responsive multinucleated nanocomplexes loaded with carbon dots for combined photothermal/chemodynamic therapy of breast cancer. ChemMedChem, (e202400983). [PMID:39821494] [10.1002/cmdc.202400983] |