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N-甲基-D-天冬氨酸, GluN1 的激动剂;GluN2A 的激动剂;GluN2B 的激动剂;GluN2C 的激动剂;GluN2D 的激动剂

兴奋毒性氨基酸
3篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
N129532-100mg
 100mg 现货 Stock Image
N129532-250mg
 250mg 现货 Stock Image
N129532-1g
 1g 现货 Stock Image
N129532-5g
 5g 期货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
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Endogenous Metabolite (978) GluN1 Agonist (8) GluN2A Agonist (8) GluN2B Agonist (8) GluN2C Agonist (7) GluN2D Agonist (7) Metabolic Enzyme/Protease (4889) 代谢物 (8911) 神经元信号传导 (3320) 离子型谷氨酸受体 (238) 离子通道 (4087) 膜转运器/离子通道 (1829)
main product photo

基本描述

英文别名 NINDS_000392 | CHEBI:31882 | (R)-2-(Methylamino)succinic acid hydrochloride | KBio2_007072 | NCGC00015666-01 | (2R)-2-(methylamino)butanedioic acid | SR-01000597701-1 | Tox21_500775 | (R)-2-Ethylbutannedioic acid | UNII-1903B9Q6PI | (R)-2-(Methylamino)suc
规格或纯度 Moligand™, ≥98%
英文名称 N-Methyl-D-aspartic acid
生化机理 兴奋毒性氨基酸。离子型NMDA谷氨酸受体上的原型激动剂，涉及长期增强，局部缺血和癫痫。也可在套件中找到：离子激动剂。也提供简单的库存解决方案（
储存温度 -20°C储存
运输条件 超低温冰袋运输
作用类型 激动剂
作用机制 GluN1 的激动剂;GluN2A 的激动剂;GluN2B 的激动剂;GluN2C 的激动剂;GluN2D 的激动剂
备注 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参阅SDS。有关溶解度，用法和处理的更多建议？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍

N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel intimately involved in spatial learning and memory, and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.

N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel intimately involved in spatial learning and memory, and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.
纯度 ≥98%

关联靶点（人）

HPN Tchem 丝氨酸蛋白酶 hepsin(Serine protease hepsin) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN1 Tclin 谷氨酸受体离子型，NMDA 1(Glutamate receptor ionotropic, NMDA 1) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN2A Tclin 谷氨酸受体离子型，NMDA 2A(Glutamate receptor ionotropic, NMDA 2A) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN2B Tclin 谷氨酸受体离子型，NMDA 2B(Glutamate receptor ionotropic, NMDA 2B) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN2C Tclin 谷氨酸受体离子型，NMDA 2C(Glutamate receptor ionotropic, NMDA 2C) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
GRIN2D Tclin 谷氨酸受体离子型，NMDA 2D(Glutamate receptor ionotropic, NMDA 2D) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FFAR3 Tchem Free fatty acid receptor 3 (304 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
POLI Tchem DNA polymerase iota (116820 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HPN Tchem Serine protease hepsin (242 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GRIN1 Tclin Ionotropic glutamate receptor NMDA 1/2D (23 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Trypsin (394 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor (6467 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Gria2 Glutamate receptor ionotropic, AMPA (2103 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Grik1 Glutamate receptor ionotropic, kainate (722 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor; Grin1/Grin2b (1028 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor; Grin1/Grin2a (798 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Grin1 Glutamate NMDA receptor; Grin1/Grin2c (1127 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504753104
分子类型 小分子
IIUPAC Name (2R)-2-(methylamino)butanedioic acid
INCHI 1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
InChi Key HOKKHZGPKSLGJE-GSVOUGTGSA-N
Smiles CNC(CC(=O)O)C(=O)O
Isomeric SMILES CN[C@H](CC(=O)O)C(=O)O
分子量 147.13
Beilstein号 1724431
Reaxy-Rn 1724430
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1724430&ln=

化学和物理性质

溶解性 DMSO 5 mg/mL Water 30 mg/mL Ethanol <1 mg/mL
比旋光度 -15° (C=2,H2O)
熔点 178 °C
分子量 147.130 g/mol
XLogP3 -3.400
氢键供体数Hydrogen Bond Donor Count 3
氢键受体数Hydrogen Bond Acceptor Count 5
可旋转键计数Rotatable Bond Count 4
精确质量Exact Mass 147.053 Da
单同位素质量Monoisotopic Mass 147.053 Da
拓扑极表面积Topological Polar Surface Area 86.600 Ų
重原子数Heavy Atom Count 10
形式电荷Formal Charge 0
复杂度Complexity 145.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 1
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

信号词 Warning
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激

H302: 吞食有害
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
RTECS CI9457000
Merck Index 6662

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批号(Lot Number) 证书类型 货号
B2209146 分析证书 N129532
C2522023 分析证书 N129532
C1918144 分析证书 N129532
K2216300 分析证书 N129532
L1419013 分析证书 N129532

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引用文献

1. Kiragasi B et al..  (2017)  A Presynaptic Glutamate Receptor Subunit Confers Robustness to Neurotransmission and Homeostatic Potentiation..  Cell Rep,  19  (13): (2694-2706).  [PMID:28658618]
2. Girling KD et al..  (2018)  Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity..  J Neurosci Res,  96  (3): (391-406).  [PMID:29193273]
3. Chamma I et al..  (2013)  Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons..  J Neurosci,  33  (39): (15488-503).  [PMID:24068817]
4. Sanchez AB et al..  (2016)  Antiretrovirals, Methamphetamine, and HIV-1 Envelope Protein gp120 Compromise Neuronal Energy Homeostasis in Association with Various Degrees of Synaptic and Neuritic Damage..  Antimicrob Agents Chemother,  60  (168-79).  [PMID:26482305]
5. Ho JW et al..  (2011)  Contributions of area Te2 to rat recognition memory..  Learn Mem,  18  (7): (493-501).  [PMID:21700715]
6. Zhang S et al..  (2013)  Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries..  J Neurosci,  33  (18): (7997-8008).  [PMID:23637190]
7. Špirková A et al..  (2022)  Glutamate can act as a signaling molecule in mouse preimplantation embryos†..  Biol Reprod,  107  (4): (916-927).  [PMID:35746896]
8. Grosser S et al..  (2014)  Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model..  PLoS One,  9  (e86250).  [PMID:24465989]
9. Thaney VE et al..  (2017)  IFNß Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury..  Sci Rep,  7  (46514).  [PMID:28425451]
10. Ledonne A et al..  (2014)  Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons..  Mol Psychiatry,  [PMID:25266126]
11. Bowers MS et al..  (2020)  NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor..  J Neurochem,  152  (5): (523-541).  [PMID:31376158]
12. Feligioni M et al..  (2009)  Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals..  Eur J Neurosci,  29  (7): (1348-56).  [PMID:19344328]
13. Ramakrishnan L et al..  (2013)  Riluzole attenuates the effects of chemoconvulsants acting on glutamatergic and GABAergic neurotransmission in the planarian Dugesia tigrina..  Eur J Pharmacol,  718  (1-3): (493-501).  [PMID:23872399]
14. Sims RE et al..  (2013)  Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro study..  PLoS One,  8  (e53814).  [PMID:23326515]
15. Kiragasi B et al..  (2020)  The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation..  Proc Natl Acad Sci U S A,  117  (41): (25830-25839).  [PMID:32973097]
16. Incontro S et al..  (2013)  The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells..  Biochim Biophys Acta,  1833  (8): (1820-31).  [PMID:23545413]
17. Mohr C et al..  (2010)  Young age and low temperature, but not female gender delay ATP loss and glutamate release, and protect Purkinje cells during simulated ischemia in cerebellar slices..  Neuropharmacology,  58  (2): (392-403).  [PMID:19825379]
18. Ting Ma, Xiaoxuan Wang, Ting Yu, Juan Liu, Zheqiong Yang, Jinlei Xi.  (2023)  Oxytetracycline changes the behavior of zebrafish larvae by inhibiting NMDA receptors.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  262  (115344).  [PMID:37567108] [10.1016/j.ecoenv.2023.115344]
19. Meixi He, Yi Wang, Xiaozhe Zhang, Lihua Zhang.  (2023)  Exploration of the potential neuroprotective compounds targeting GluN1-GluN2B NMDA receptors.  JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,  [PMID:36591642] [10.1080/07391102.2022.2159527]
20. Meixi He, Yingang Feng, Yi Wang, Mengchun Cheng, Xiaozhe Zhang, Lihua Zhang.  (2022)  Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume.  FITOTERAPIA,  163  (105338).  [PMID:36270560] [10.1016/j.fitote.2022.105338]

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