| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N114456-100mg |
100mg |
现货  |
|
| 别名 | 百螺杀 |
|---|---|
| 英文别名 | NCGC00015735-07 | SCHEMBL67182 | Spectrum5_001083 | 2',5-Dichloro-4'-nitrosalicylanilide | CHEBI:7553 | BAY-2353 | Niclocide (TN) | Vermitid | CCRIS 3437 | Bayluscid | DTXCID5020362 | NICLOSAMIDE [USAN] | Spectrum3_000667 | Tredemine | Bayer 2353 | N-(2'- |
| 规格或纯度 | Moligand™, 分析标准品 |
| 英文名称 | Niclosamide |
| 应用 | 氯硝柳胺是一种驱虫药。对感染人类的绦虫非常有效。氯硝柳胺常用来研究Wnt/Frizzled-1信号传导通路。它查查用于在AML细胞中抑制转录和DNA结合到NF-κB和转录，以及ito诱导凋亡 |
| 运输条件 | 常规运输 |
| 作用类型 | 激活剂 |
| 作用机制 | K Na1.1 激活剂 |
| 产品介绍 |
水溶解度为5-8ppm，溶于热乙醇、环已酮、氢氧化钠液。 氯硝柳胺是一种驱虫药。对感染人类的绦虫非常有效。氯硝柳胺常用来研究Wnt/Frizzled-1信号传导通路。它查查用于在AML细胞中抑制转录和DNA结合到NF-κB和转录，以及ito诱导凋亡 Niclosamide is anthelmintic medicine. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis |
| ALogP | 4 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 200-056-8, 215-811-7 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
| INCHI | 1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) |
| InChi Key | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
| Smiles | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O |
| Isomeric SMILES | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O |
| 关联CAS | 50-65-7,1420-04-8,1420-04-8 (2-aminoethanol (1:1)) |
| NSC Number | 178296 |
| UN Number | 3077 |
| MeSH Entry Terms | Bayer 2353;Bayer 73;Bayluscide;Clonitralide;Fenasal;Niclocide;Niclosamide;Niclosamide, 2-Aminoethanol (1:1);Phenasal;Radewerm;Tr\u00e9d\u00e9mine;Yomesan |
| 分子量 | 327.12 |
| Beilstein号 | 2820605 |
| Reaxy-Rn | 2820605 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2820605&ln= |
| 密度 | 1.161 |
|---|---|
| 熔点 | 225-230°C |
| 分子量 | 327.120 g/mol |
| XLogP3 | 4.000 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 325.986 Da |
| 单同位素质量Monoisotopic Mass | 325.986 Da |
| 拓扑极表面积Topological Polar Surface Area | 95.200 Ų |
| 重原子数Heavy Atom Count | 21 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 404.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07, GHS09 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H319: 引起严重眼睛刺激 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 |
| 预防措施声明 |
P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P391: 收集溢出物 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| WGK Germany | 2 |
| RTECS | VN8400000 |
| 个人防护装备 | Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter |
| 1. Sliwoski G, Schubert M, Stichel J, Weaver D, Beck-Sickinger AG, Meiler J. (2016) Discovery of Small-Molecule Modulators of the Human Y4 Receptor.. PLoS ONE, 11 (6): (e0157146). [PMID:27294784] |
| 2. Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C et al.. (2016) Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.. Nat Med, 22 (10): (1101-1107). [PMID:27571349] |
| 3. Hao Wu, Xiping Yuan, Min Xie, Jinwei Gao, Zhenzhen Xiong, Rui Song, Zhonggui Xie, Dongsheng Ou. (2023) The Impact of Niclosamide Exposure on the Activity of Antioxidant Enzymes and the Expression of Glucose and Lipid Metabolism Genes in Black Carp (Mylopharyngodon piceus). Genes, 14 (12): (2196). [PMID:38137017] [10.3390/genes14122196] |
| 4. Han Jiale, Liu Yunhang, Li Fang, Zhu Gan, Guo Meimei, Zhao Hongyuan. (2023) Nanocomposite of graphitized and carboxylated multi-walled carbon nanotubes and chitosan for the highly sensitive detection of niclosamide. IONICS, 29 (8): (3407-3419). [10.1007/s11581-023-05077-w] |
| 5. Jing Xiang, Hao Wu, Jinwei Gao, Weimin Jiang, Xing Tian, Zhonggui Xie, Tao Zhang, Jia Feng, Rui Song. (2023) Niclosamide exposure disrupts antioxidant defense, histology, and the liver and gut transcriptome of Chinese soft-shelled turtle (Pelodiscus sinensis). ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 260 (115081). [PMID:37262966] [10.1016/j.ecoenv.2023.115081] |
| 6. Yunhang Liu, Qian Wang, Gan Zhu, Qiwen Ran, Fang Li, Meimei Guo, Guifang Wang, Hongyuan Zhao. (2023) Novel electrochemical sensing platform based on palygorskite nanorods/Super P Li carbon nanoparticles-graphitized carbon nanotubes nanocomposite for sensitive detection of niclosamide. CERAMICS INTERNATIONAL, 49 (21234). [10.1016/j.ceramint.2023.03.253] |
| 7. Wei Zhong, Jin Zou, Qi Yu, Yansha Gao, Fengli Qu, Shuwu Liu, Hui Zhou, Limin Lu. (2023) Ultrasensitive indirect electrochemical sensing of thiabendazole in fruit and water by the anodic stripping voltammetry of Cu2+ with hierarchical Ti3C2Tx-TiO2 for signal amplification. FOOD CHEMISTRY, 402 (134379). [PMID:36179525] [10.1016/j.foodchem.2022.134379] |
| 8. Cuiling Wang, Fang Li, Jinna Li, Liusu Cui, Jiateng Zhong, Hongyuan Zhao, Sridhar Komarneni. (2022) Highly sensitive determination of niclosamide based on chitosan functionalized carbon nanotube/carbon black scaffolds with interconnected long- and short-range conductive network. Journal of Materials Research and Technology-JMR&T, 19 (4525). [10.1016/j.jmrt.2022.07.001] |
| 9. Fang Li, Runqiang Liu, Volodymyr Dubovyk, Qiwen Ran, Bo Li, Yuqi Chang, Hongliang Wang, Hongyuan Zhao, Sridhar Komarneni. (2022) Three-dimensional hierarchical porous carbon coupled with chitosan based electrochemical sensor for sensitive determination of niclosamide. FOOD CHEMISTRY, 366 (130563). [PMID:34289441] [10.1016/j.foodchem.2021.130563] |
| 10. Hae-Ni Jung, Da-Hee Park, Kyung-Hee Yoo, Hee-Jung Cho, Jae-Han Shim, Ho-Chul Shin, A.M. Abd El-Aty. (2021) Simultaneous quantification of 12 veterinary drug residues in fishery products using liquid chromatography-tandem mass spectrometry. FOOD CHEMISTRY, 348 (129105). [PMID:33508596] [10.1016/j.foodchem.2021.129105] |
| 11. Hongyuan Zhao, Yuqi Chang, Runqiang Liu, Bo Li, Fang Li, Fulong Zhang, Mingwang Shi, Lin Zhou, Xiaoguang Li. (2021) Facile synthesis of Vulcan XC-72 nanoparticles-decorated halloysite nanotubes for the highly sensitive electrochemical determination of niclosamide. FOOD CHEMISTRY, 343 (128484). [PMID:33129617] [10.1016/j.foodchem.2020.128484] |
| 12. Hao Wu, Xiping Yuan, Xing Tian, Jinwei Gao, Min Xie, Zhonggui Xie, Rui Song, Dongsheng Ou. (2024) Investigating Immunotoxicity in Black Carp (Mylopharyngodon piceus) Fingerlings Exposed to Niclosamide. Life-Basel, 14 (5): (544). [PMID:38792567] [10.3390/life14050544] |
| 13. Hao Wu, Xiping Yuan, Yong He, Jinwei Gao, Min Xie, Zhonggui Xie, Rui Song, Dongsheng Ou. (2024) Niclosamide subacute exposure alters the immune response and microbiota of the gill and gut in black carp larvae, Mylopharyngodon piceus. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 279 (116512). [PMID:38805826] [10.1016/j.ecoenv.2024.116512] |
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