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α-萘黄酮

9篇引用文献 COA COA
    级别和纯度:
  • ≥98%
有货

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货号 (SKU) 包装规格 是否现货 价格 数量
N113472-1g
 1g 现货 Stock Image
N113472-5g
 5g 现货 Stock Image
N113472-25g
 25g 现货 Stock Image
大包装询价 收藏夹 比较  SDS下载  DATASHEET  质量标准
查看相关系列
Apoptosis (7108) Cytochrome P450 (243) Metabolic Enzyme/Protease (4889) 六元杂环化合物 (1701) 脂质代谢 (4331) 苯并吡喃类 (63)
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基本描述

别名 苯并黄素 | 7,8-苯并黄酮
英文别名 2-phenyl-4-benzo[h][1]benzopyranone | DTXSID2040650 | A-NAPHTHYLFLAVONE | CCRIS-3607 | F16466 | alpha -Naphthoflavone | alpha-Naphthoflavone | BDBM50014323 | HMS3740O15 | FML65D8PY5 | 2-Phenyl-4H-naphtho(1,2-b)pyran-4-one | .alpha.-Naphthylflavone | 4H-Na
规格或纯度 ≥98%
英文名称 α-Naphthoflavone
应用 An aryl hydrocarbon receptor inhibitor.
储存温度 2-8°C储存
运输条件 冰袋运输
产品介绍

α-Naphthoflavone is a naturally occurring compound found in Passiflora. α-Naphthoflavone is an aryl hydrocarbon receptor antagonist and inhibitor of CYP1A1 gene expression. Experiments show inhibitory properties towards cytochrome P450 enzymes, CYP1A1 (P4501A1) and CYP1A2 (P4501A2) (competetive binding) with stimulatory activities towards CYP3A4 (P4503A4) (selective binding). α-Naphthoflavone is an inhibitor of CYP19.An aryl hydrocarbon receptor inhibitor.

α-Naphthoflavone is a naturally occurring compound found in Passiflora. α-Naphthoflavone is an aryl hydrocarbon receptor antagonist and inhibitor of CYP1A1 gene expression. Experiments show inhibitory properties towards cytochrome P450 enzymes, CYP1A1 (P4501A1) and CYP1A2 (P4501A2) (competetive binding) with stimulatory activities towards CYP3A4 (P4503A4) (selective binding). α-Naphthoflavone is an inhibitor of CYP19.
An aryl hydrocarbon receptor inhibitor.
纯度 ≥98%

关联靶点（人）

CYP1A2 Tchem 细胞色素 P450 1A2(Cytochrome P450 1A2) (31 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CYP1B1 Tchem 细胞色素 P450 1B1(Cytochrome P450 1B1) (25 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CYP19A1 Tclin 芳香化酶(Aromatase) (2 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
CYP1A1 Tchem 细胞色素 P450 1A1(Cytochrome P450 1A1) (20 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
INSR Tclin Insulin receptor (5558 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PGR Tclin Progesterone receptor (8562 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AR Tclin Androgen Receptor (11781 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP19A1 Tclin Cytochrome P450 19A1 (6099 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
XDH Tclin Xanthine dehydrogenase (1038 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNH2 Tclin HERG (29587 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ESR2 Tclin Estrogen receptor beta (9272 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Sigmar1 Sigma opioid receptor (160 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cruzipain (33337 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Cckar Cholecystokinin A receptor (90 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Abcc1 Multidrug resistance-associated protein 1 (42 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Abcb1b P-glycoprotein 1 (174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
lef Anthrax lethal factor (7585 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Mapt Microtubule-associated protein tau (6 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP3A6 Cytochrome P450 3A6 (2 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Glra2 Glycine receptor (1745 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
lipT Carboxylic ester hydrolase (1 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 504752197
EC号 210-071-1
分子类型 小分子
IIUPAC Name 2-phenylbenzo[h]chromen-4-one
INCHI 1S/C19H12O2/c20-17-12-18(14-7-2-1-3-8-14)21-19-15-9-5-4-6-13(15)10-11-16(17)19/h1-12H
InChi Key VFMMPHCGEFXGIP-UHFFFAOYSA-N
Smiles C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
Isomeric SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3
UN Number 1325
分子量 272.3
Beilstein号 210494
Reaxy-Rn 210862
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=210862&ln=

化学和物理性质

溶解性 Soluble in methanol:ethyl acetate(2:3) (50 mg/ml), chloroform (slightly), sulfuric acid, and hot ethanol. Insoluble in water.
密度 1.276
敏感性 对光线敏感
熔点 155-158°C
分子量 272.300 g/mol
XLogP3 4.800
氢键供体数Hydrogen Bond Donor Count 0
氢键受体数Hydrogen Bond Acceptor Count 2
可旋转键计数Rotatable Bond Count 1
精确质量Exact Mass 272.084 Da
单同位素质量Monoisotopic Mass 272.084 Da
拓扑极表面积Topological Polar Surface Area 26.300 Ų
重原子数Heavy Atom Count 21
形式电荷Formal Charge 0
复杂度Complexity 433.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

WGK Germany 3
RTECS QL6250000
个人防护装备 Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

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批号(Lot Number) 证书类型 货号
F2421325 分析证书 N113472
J1515156 分析证书 N113472
J2227554 分析证书 N113472
J2227558 分析证书 N113472
J2227595 分析证书 N113472
F2520069 分析证书 N113472
A2415436 分析证书 N113472
E1828030 分析证书 N113472
E1828031 分析证书 N113472
C2223022 分析证书 N113472

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引用文献

1. Griffin RJ, Fontana G, Golding BT, Guiard S, Hardcastle IR, Leahy JJ, Martin N, Richardson C, Rigoreau L, Stockley M et al..  (2005)  Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro..  J Med Chem,  48  (2): (569-85).  [PMID:15658870]
2. Fontana E, Dansette PM, Poli SM.  (2005)  Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity..  Curr Drug Metab,  6  (5): (413-54).  [PMID:16248836]
3. Bruno RD, Njar VC.  (2007)  Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development..  Bioorg Med Chem,  15  (15): (5047-60).  [PMID:17544277]
4. Muftuoglu Y, Mustata G.  (2010)  Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19)..  Bioorg Med Chem Lett,  20  (10): (3050-64).  [PMID:20413308]
5. Xiao Y Wei,Chung Y Leung,Chris K C Wong,Xiao L Shen,Ricky N S Wong,Zong W Cai,Nai K Mak.  (2005-03-25)  Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica..  Journal of natural products,  68  ((3)): (427-429).  [PMID:15787451]
6. Makoto Matsumoto,Hiroyuki Hashizume,Tatsuo Tomishige,Masanori Kawasaki,Hidetsugu Tsubouchi,Hirofumi Sasaki,Yoshihiko Shimokawa,Makoto Komatsu.  (2006-11-30)  OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice..  PLoS medicine,  3  ((11)): (e466-e466).  [PMID:17132069]
7. Anja Krick,Stefan Kehraus,Clarissa Gerhäuser,Karin Klimo,Martin Nieger,Armin Maier,Heinz-Herbert Fiebig,Iuliana Atodiresei,Gerhard Raabe,Jörg Fleischhauer,Gabriele M König.  (2007-02-13)  Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis..  Journal of natural products,  70  ((3)): (353-360).  [PMID:17291041]
8. Samir Yahiaoui,Catherine Fagnere,Christelle Pouget,Jacques Buxeraud,Albert-José Chulia.  (2007-11-29)  New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation..  Bioorganic & medicinal chemistry,  16  ((3)): (1474-1480).  [PMID:18042388]
9. Ioana Ferecatu,Marie-Caroline Borot,Camille Bossard,Melanie Leroux,Nicole Boggetto,Francelyne Marano,Armelle Baeza-Squiban,Karine Andreau.  (2010-07-29)  Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor..  Particle and fibre toxicology,  7  (18-18).  [PMID:20663163]
10. Lin He,Fan He,Huichang Bi,Jiankang Li,Su Zeng,Hai-Bin Luo,Min Huang.  (2010-09-14)  Isoform-selective inhibition of chrysin towards human cytochrome P450 1A2. Kinetics analysis, molecular docking, and molecular dynamics simulations..  Bioorganic & medicinal chemistry letters,  20  ((20)): (6008-6012).  [PMID:20832301]
11. Takeyuki Takamura,Daisuke Harama,Suguru Fukumoto,Yuki Nakamura,Naomi Shimokawa,Kayoko Ishimaru,Shuji Ikegami,Seiya Makino,Masanori Kitamura,Atsuhito Nakao.  (2011-02-16)  Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis..  Immunology and cell biology,  89  ((7)): (817-822).  [PMID:21321579]
12. Abdullah Mayati,Eric Le Ferrec,Dominique Lagadic-Gossmann,Olivier Fardel.  (2011-04-01)  Aryl hydrocarbon receptor-independent up-regulation of intracellular calcium concentration by environmental polycyclic aromatic hydrocarbons in human endothelial HMEC-1 cells..  Environmental toxicology,  27  ((9)): (556-562).  [PMID:21452393]
13. Qiang Shi,Xi Yang,James Greenhaw,William F Salminen.  (2011-05-07)  Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes..  Toxicological sciences : an official journal of the Society of Toxicology,  122  ((2)): (579-586).  [PMID:21546349]
14. Minoru Hirano,Shiho Tanaka,Osamu Asami.  (2011-09-03)  Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray..  Environmental toxicology,  28  ((11)): (652-659).  [PMID:21887816]
15. Soon Young Shin,Yoonkyung Woo,Jiye Hyun,Yeonjoong Yong,Dongsoo Koh,Young Han Lee,Yoongho Lim.  (2011-09-13)  Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities..  Bioorganic & medicinal chemistry letters,  21  ((20)): (6036-6041).  [PMID:21907578]
16. Yong-Xian Shao,Peng Zhao,Zhe Li,Ming Liu,Peiqing Liu,Min Huang,Hai-Bin Luo.  (2012-01-10)  The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin..  European biophysics journal : EBJ,  41  ((3)): (297-306).  [PMID:22228220]
17. Min Ji Kim,Véronique Pelloux,Erwan Guyot,Joan Tordjman,Linh-Chi Bui,Aline Chevallier,Claude Forest,Chantal Benelli,Karine Clément,Robert Barouki.  (2012-01-21)  Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells..  Environmental health perspectives,  120  ((4)): (508-514).  [PMID:22262711]
18. Olga Beltrán-Ramírez,Roberto Macías Pérez,Adolfo Sierra-Santoyo,Saúl Villa-Treviño.  (2012-02-01)  Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis..  Toxicologic pathology,  40  ((3)): (466-472).  [PMID:22291063]
19. Prashant Kumar Jaiswal,Shaili Srivastava,Jyotsana Gupta,Indu Shekhar Thakur.  (2012-09-05)  Dibenzofuran induces oxidative stress, disruption of trans-mitochondrial membrane potential (ΔΨm) and G1 arrest in human hepatoma cell line..  Toxicology letters,  214  ((2)): (137-144).  [PMID:22944260]
20. Dehui Xu,Jinsong Hu,Elke De Bruyne,Eline Menu,Rik Schots,Karin Vanderkerken,Els Van Valckenborgh.  (2012-11-01)  Dll1/Notch activation contributes to bortezomib resistance by upregulating CYP1A1 in multiple myeloma..  Biochemical and biophysical research communications,  428  ((4)): (518-524).  [PMID:23111325]
21. Qiqiang He,Caixuan Huang,Lihua Zhao,Jing Feng,Qun Shi,Dengshun Wang,Suqing Wang.  (2013-01-19)  α-Naphthoflavone inhibits 3T3-L1 pre-adipocytes differentiation via modulating p38MAPK signaling..  International journal of clinical and experimental pathology,  6  ((2)): (168-178).  [PMID:23330002]
22. Marketa Martinkova,Bozena Kubickova,Marie Stiborova.  (2013-01-29)  Effects of cytochrome P450 inhibitors on peroxidase activity..  Neuro endocrinology letters,  33 Suppl 3  (33-40).  [PMID:23353841]
23. Sun Min Lim,Jee Won Hwang,Joong Bae Ahn,Soo Kyung Bae,Chan Hee Park,Ki-Yeol Kim,Sun Young Rha,Hyun Cheol Chung,Jae Kyung Roh,Sang Joon Shin.  (2013-06-12)  Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon cancer cells..  Anticancer research,  33  ((6)): (2499-2508).  [PMID:23749901]
24. Susanne Gauggel-Lewandowski,Alexandra H Heussner,Pablo Steinberg,Bart Pieterse,Bart van der Burg,Daniel R Dietrich.  (2013-06-26)  Bioavailability and potential carcinogenicity of polycyclic aromatic hydrocarbons from wood combustion particulate matter in vitro..  Chemico-biological interactions,  206  ((2)): (411-422).  [PMID:23796820]
25. Julia Dinger,Markus R Meyer,Hans H Maurer.  (2014-05-17)  Development and validation of a liquid-chromatography high-resolution tandem mass spectrometry approach for quantification of nine cytochrome P450 (CYP) model substrate metabolites in an in vitro CYP inhibition cocktail..  Analytical and bioanalytical chemistry,  406  ((18)): (4453-4464).  [PMID:24830396]
26. Julia Dinger,Markus R Meyer,Hans H Maurer.  (2014-11-25)  In vitro cytochrome P450 inhibition potential of methylenedioxy-derived designer drugs studied with a two-cocktail approach..  Archives of toxicology,  90  ((2)): (305-318).  [PMID:25417051]
27. Julia Dinger,Campbell Woods,Simon D Brandt,Markus R Meyer,Hans H Maurer.  (2015-11-26)  Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class..  Toxicology letters,  241  (82-94).  [PMID:26599973]
28. Raghava Choudary Palacharla,Venkatesham Uthukam,Arunkumar Manoharan,Ranjith Kumar Ponnamaneni,Nagasurya Prakash Padala,Rajesh Kumar Boggavarapu,Gopinadh Bhyrapuneni,Devender Reddy Ajjala,Ramakrishna Nirogi.  (2017-02-10)  Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clearance..  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,  101  (80-89).  [PMID:28179134]
29. Barbara M Zietek,Marija Mladic,Ben Bruyneel,Wilfried M A Niessen,Maarten Honing,Govert W Somsen,Jeroen Kool.  (2017-12-22)  Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures..  SLAS discovery : advancing life sciences R & D,  23  ((3)): (283-293).  [PMID:29262760]
30. Lu Han,Rong Wang,Bin Wu,Yanqiu Gu,Yongfang Yuan.  (2018-09-15)  Effect of diammonium glycyrrhizinate on pharmacokinetics of omeprazole by regulating cytochrome P450 enzymes and plasma protein binding rate..  Xenobiotica; the fate of foreign compounds in biological systems,  49  ((8)): (975-980).  [PMID:30215539]
31. Ruijuan Liu,Fang Zhou,He He,Jingyao Wei,Xin Tian,Li Ding.  (2018-11-22)  Metabolism and Bioactivation of Corynoline With Characterization of the Glutathione/Cysteine Conjugate and Evaluation of Its Hepatotoxicity in Mice..  Frontiers in pharmacology,  9  (1264-1264).  [PMID:30459618]
32. Carolina B Moraes,Gesa Witt,Maria Kuzikov,Bernhard Ellinger,Theodora Calogeropoulou,Kyriakos C Prousis,Stefano Mangani,Flavio Di Pisa,Giacomo Landi,Lucia Dello Iacono,Cecilia Pozzi,Lucio H Freitas-Junior,Bruno Dos Santos Pascoalino,Claudia P Bertolacini,Birte Behrens,Oliver Keminer,Jennifer Leu,Markus Wolf,Jeanette Reinshagen,Anabela Cordeiro-da-Silva,Nuno Santarem,Alberto Venturelli,Stephen Wrigley,Deepa Karunakaran,Bethlehem Kebede,Ina Pöhner,Wolfgang Müller,Joanna Panecka-Hofman,Rebecca C Wade,Martina Fenske,Joachim Clos,José María Alunda,María Jesús Corral,Elisa Uliassi,Maria Laura Bolognesi,Pasquale Linciano,Antonio Quotadamo,Stefania Ferrari,Matteo Santucci,Chiara Borsari,Maria Paola Costi,Sheraz Gul.  (2019-02-21)  Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform..  SLAS discovery : advancing life sciences R & D,  24  ((3)): (346-361).  [PMID:30784368]
33. Marina Domingo-Vidal,Diana Whitaker-Menezes,Cristina Martos-Rus,Patrick Tassone,Christopher M Snyder,Madalina Tuluc,Nancy Philp,Joseph Curry,Ubaldo Martinez-Outschoorn.  (2019-06-27)  Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma..  Molecular cancer research : MCR,  17  ((9)): (1893-1909).  [PMID:31239287]
34. Chi-Hao Tsai,Ching-Hao Li,Po-Lin Liao,Yu-Wei Chang,Yu-Wen Cheng,Jaw-Jou Kang.  (2019-11-02)  Aza-PBHA, a potent histone deacetylase inhibitor, inhibits human gastric-cancer cell migration via PKCα-mediated AHR-HDAC interactions..  Biochimica et biophysica acta. Molecular cell research,  1867  ((2)): (118564-118564).  [PMID:31672612]
35. Man Zhang,Heng Fan,Songwei Tan,Qing Tang,Xingxing Liu,Dongmei Zuo,Yi Liao,Zhen Nan,Chen Tan.  (2020-01-10)  The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation..  Journal of ethnopharmacology,  251  (112549-112549).  [PMID:31918016]
36. Leonard Blum,Sheraz Gul,Thomas Ulshöfer,Marina Henke,Reimar Krieg,Isabell Berneburg,Dominique Thomas,Sandra Trautmann,Jennifer Kurz,Joachim Geyer,Gerd Geisslinger,Katja Becker,Michael J Parnham,Susanne Schiffmann.  (2020-05-07)  In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o..  Scientific reports,  10  ((1)): (7534-7534).  [PMID:32371995]
37. An Wang,Uzen Savas,C David Stout,Eric F Johnson.  (2010-12-15)  Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1..  The Journal of biological chemistry,  286  ((7)): (5736-5743).  [PMID:21147782]
38. G J Diaz,H W Murcia,S M Cepeda.  (2010-12-17)  Bioactivation of aflatoxin B1 by turkey liver microsomes: responsible cytochrome P450 enzymes..  British poultry science,  51  ((6)): (828-837).  [PMID:21161791]
39. Daniel J Frank,Ilia G Denisov,Stephen G Sligar.  (2010-12-24)  Analysis of heterotropic cooperativity in cytochrome P450 3A4 using alpha-naphthoflavone and testosterone..  The Journal of biological chemistry,  286  ((7)): (5540-5545).  [PMID:21177853]
40. Karina A Barreiro,María P Di Yorio,Romina D Artillo-Guida,Dante A Paz,Alicia G Faletti.  (2011-01-26)  Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat..  Toxicology and applied pharmacology,  252  ((1)): (11-17).  [PMID:21262252]
41. Flavia Girolami,Veronica Spalenza,Monica Carletti,Giovanni Perona,Paola Sacchi,Roberto Rasero,Carlo Nebbia.  (2011-08-02)  Gene expression and inducibility of the aryl hydrocarbon receptor-dependent pathway in cultured bovine blood lymphocytes..  Toxicology letters,  206  ((2)): (204-209).  [PMID:21803134]
42. Bhupendra Singh,Nimee K Bhat,Hari K Bhat.  (2011-11-11)  Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer..  Carcinogenesis,  33  ((1)): (156-163).  [PMID:22072621]
43. Po-Lin Liao,Ching-Hao Li,Cheng-Yi Chang,Siang-Rong Lu,Cheng-Hui Lin,Ling-Shan Tse,Yu-Wen Cheng.  (2012-06-22)  Anti-ageing effects of alpha-naphthoflavone on normal and UVB-irradiated human skin fibroblasts..  Experimental dermatology,  21  ((7)): (546-548).  [PMID:22716253]
44. H G Lee,J H Yang.  (2012-07-04)  PCB126 induces apoptosis of chondrocytes via ROS-dependent pathways..  Osteoarthritis and cartilage,  20  ((10)): (1179-1185).  [PMID:22750746]
45. Elena Galfrè,Lauretta Galeno,Oscar Moran.  (2012-07-04)  A potentiator induces conformational changes on the recombinant CFTR nucleotide binding domains in solution..  Cellular and molecular life sciences : CMLS,  69  ((21)): (3701-3713).  [PMID:22752155]
46. Hidesuke Fukazawa,Tetsuro Suzuki,Takaji Wakita,Yuko Murakami.  (2012-08-07)  A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus..  Biological & pharmaceutical bulletin,  35  ((8)): (1320-1327).  [PMID:22863932]
47. Anne Van Vlaslaer,Russell J Mortishire-Smith,Claire Mackie,Xavier Langlois,Mark E Schmidt.  (2013-02-15)  Profiling of hepatic clearance pathways of Pittsburgh compound B and human liver cytochrome p450 phenotyping..  EJNMMI research,  3  ((1)): (10-10).  [PMID:23406885]
48. You-Jung Hwang,Mi-Ok Yun,Kyu-Tae Jeong,Joo-Hung Park.  (2013-12-03)  Uremic toxin indoxyl 3-sulfate regulates the differentiation of Th2 but not of Th1 cells to lessen allergic asthma..  Toxicology letters,  225  ((1)): (130-138).  [PMID:24291743]
49. Masashi Sekimoto,Haruna Sumi,Takuomi Hosaka,Takashi Umemura,Akiyoshi Nishikawa,Masakuni Degawa.  (2016-10-30)  Aryl hydrocarbon receptor activation and CYP1A induction by cooked food-derived carcinogenic heterocyclic amines in human HepG2 cell lines..  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,  97  (256-264).  [PMID:27644595]
50. Ying-Yuan Lu,Hai-Xu Cheng,Xin Wang,Xiao-Wei Wang,Jun-Yi Liu,Pu Li,Ya-Qing Lou,Jun Li,Chuang Lu,Guo-Liang Zhang.  (2016-12-03)  Identification of cytochrome P450s involved in the metabolism of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) using human recombinant enzymes and rat liver microsomes in vitro..  Xenobiotica; the fate of foreign compounds in biological systems,  47  ((8)): (667-672).  [PMID:27910729]
51. Cintia Scucuglia Heluany,Leonard de Vinci Kanda Kupa,Mariana Nascimento Viana,Cristina Maria Fernandes,Eduardo Lani Volpe Silveira,Sandra Helena Poliselli Farsky.  (2018-06-25)  In vivo exposure to hydroquinone during the early phase of collagen-induced arthritis aggravates the disease..  Toxicology,  408  (22-30).  [PMID:29935983]
52. Le P Ngo,Tze Khee Chan,Jing Ge,Leona D Samson,Bevin P Engelward.  (2019-02-07)  Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation..  Cell reports,  26  ((6)): (1668-1678).  [PMID:30726746]
53. Vinay R Sonawane,Mohd Usman Mohd Siddique,Linda Gatchie,Ibidapo S Williams,Sandip B Bharate,Venkatesan Jayaprakash,Barij N Sinha,Bhabatosh Chaudhuri.  (2019-02-19)  CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance..  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,  131  (177-194).  [PMID:30776468]
54. Gui-Zhen Wang,Li Zhang,Xin-Chun Zhao,San-Hui Gao,Li-Wei Qu,Hong Yu,Wen-Feng Fang,Yong-Chun Zhou,Fan Liang,Chen Zhang,Yun-Chao Huang,Zhihua Liu,Yang-Xin Fu,Guang-Biao Zhou.  (2019-03-10)  The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy..  Nature communications,  10  ((1)): (1125-1125).  [PMID:30850589]
55. Xiaoxi Yang,Tingting Ku,Zhendong Sun,Qian S Liu,Nuoya Yin,Qunfang Zhou,Francesco Faiola,Chunyang Liao,Guibin Jiang.  (2019-05-15)  Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo..  Toxicology letters,  312  (139-147).  [PMID:31082521]
56. Jayme P Coyle,Raymond C Derk,Tiffany G Kornberg,Dilpreet Singh,Jake Jensen,Sherri Friend,Robert Mercer,Todd A Stueckle,Philip Demokritou,Yon Rojanasakul,Liying W Rojanasakul.  (2020-08-14)  Carbon nanotube filler enhances incinerated thermoplastics-induced cytotoxicity and metabolic disruption in vitro..  Particle and fibre toxicology,  17  ((1)): (40-40).  [PMID:32787867]
57. Bikash Dangi,Nadezhda Y Davydova,Marc A Maldonado,Armina Abbasi,Nikita E Vavilov,Victor G Zgoda,Dmitri R Davydov.  (2020-11-17)  Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4..  Archives of biochemistry and biophysics,  698  (108677-108677).  [PMID:33197431]
58. Shuaishuai Chen, Weiyu Guo, Huan Liu, Jiang Zheng, Dingyan Lu, Jia Sun, Chun Li, Chunhua Liu, Yonglin Wang, Yong Huang, Wen Liu, Yongjun Li, Ting Liu.  (2023)  Mechanistic study of cytochrome P450 enzyme-mediated cytotoxicity of psoralen and isopsoralen.  FOOD AND CHEMICAL TOXICOLOGY,  180  (114011).  [PMID:37660943] [10.1016/j.fct.2023.114011]
59. Xiaole Zhao, Xiaoyong Huang, Wenjing Peng, Muke Han, Xin Zhang, Kui Zhu, Bing Shao.  (2022)  Chlorine disinfection byproduct of diazepam affects nervous system function and possesses gender-related difference in zebrafish.  ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,  238  (113568).  [PMID:35490575] [10.1016/j.ecoenv.2022.113568]
60. Xiaoke Zheng, Hanyu Yang, Lan Qin, Siqian Wang, Lei Xie, Lu Yang, Weimin Kong, Liang Zhu, Li Liu, Xiaodong Liu.  (2021)  Bile Duct Ligation Upregulates Expression and Function of L-Amino Acid Transporter 1 at Blood–Brain Barrier of Rats via Activation of Aryl Hydrocarbon Receptor by Bilirubin.  Biomedicines,  9  (10): (1320).  [PMID:34680437] [10.3390/biomedicines9101320]
61. Ziming Zheng, Yu Zhang, Yuxuan Liu, Jinglin Wang, Zheng Cui, Xianglin Pan, Yan Liu, Wenqi Tang, Kaiping Wang.  (2021)  Metabolic degradation of lentinan in liver mediated by CYP450 enzymes and epoxide hydrolase.  CARBOHYDRATE POLYMERS,  253  (117255).  [PMID:33279005] [10.1016/j.carbpol.2020.117255]
62. Bayarmaa Khadankhuu, Yuxiang Fei, Dan Xu, Yingchao Li, Kai Hou, Fengyang Li, Weirong Fang, Xijing Chen, Yunman Li.  (2020)  Pharmacokinetics and pharmacodynamics analysis of XQ-1H and its combination therapy with clopidogrel on cerebral ischemic reperfusion injury in rats.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  179  (112975).  [PMID:31735472] [10.1016/j.jpba.2019.112975]
63. Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng, Jiang Zheng.  (2019)  Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism.  DRUG METABOLISM AND DISPOSITION,  47  (8): (919-927).  [PMID:31147316] [10.1124/dmd.119.086892]
64. Danyi Lu, Zhiguo Ma, Tianpeng Zhang, Xingwang Zhang, Baojian Wu.  (2016)  Metabolism of the anthelmintic drug niclosamide by cytochrome P450 enzymes and UDP-glucuronosyltransferases: metabolite elucidation and main contributions from CYP1A2 and UGT1A1.  XENOBIOTICA,  46  (1): (1-13).  [PMID:26068521] [10.3109/00498254.2015.1047812]
65. Lili Wu, Wanping Zhong, Junjin Liu, Weichao Han, Shilong Zhong, Qiang Wei, Shuwen Liu, Lan Tang.  (2015)  Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat.  FITOTERAPIA,  105  (26).  [PMID:26045316] [10.1016/j.fitote.2015.05.021]
66. Baofu Xie, Yue Liu, Chunhong Chen, Tony Velkov, Shusheng Tang, Jianzhong Shen, Chongshan Dai.  (2024)  Colistin Induces Oxidative Stress and Apoptotic Cell Death through the Activation of the AhR/CYP1A1 Pathway in PC12 Cells.  Antioxidants,  13  (7): (827).  [PMID:39061896] [10.3390/antiox13070827]

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