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柚皮苷

58篇引用文献 COA COA
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货号 (SKU) 包装规格 是否现货 价格 数量
N107345-5g
 5g 现货 Stock Image
N107345-25g
 25g 现货 Stock Image
N107345-100g
 100g 现货 Stock Image
N107345-500g
 500g 期货 Stock Image
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Autophagy (2848) Cytochrome P450 (243) Endogenous Metabolite (978) Metabolic Enzyme/Protease (4889) 二糖 (89) 代谢物 (8911) 六元杂环化合物 (1701) 脂质代谢 (4331)
main product photo

基本描述

别名 (S)- 7-[[2-O-(6-脱氧-α-L-甘露吡喃基)-β-D-葡萄吡喃基]氧代]-2,3-二氢-5-羟基-2-(4-羟苯基)-4H-1-苯并吡喃-4-酮 | 川陈皮素 | 柚皮甙 | 4,5,7-三羟基黄酮 7-鼠李糖苷 | 柚皮素 7-新橙皮苷 | 柚皮素-7-鼠李糖苷 | 柚皮苷 | 柚皮苷 水合物 | 川陈皮素 水合物 | 4,5,7- 三羟基黄烷酮-7- 鼠李糖葡萄糖苷 | 4‘;5,7-三羟基黄酮 7-鼠李糖苷 | 柚皮素 7-新橙皮苷 | 柚皮素-7-鼠李糖苷 | 柚皮苷水合物 | 柚甙
英文别名 (2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside | (2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-betaD-glucopyranos
规格或纯度 Moligand™, ≥95%
英文名称 Naringin
生化机理 柚皮苷是葡萄柚和其他柑橘类水果中的一种黄酮类化合物，能有效抑制肠道有机阴离子转运多肽 1A2（OATP1A2）。因此，葡萄柚汁可降低同时服用多种药剂的生物利用度。
储存温度 充氩
运输条件 常规运输
产品介绍

柚皮苷用于：
作为苦味剂，比较 果蝇 幼虫和成虫的行为反应
研究其抗炎特性，确定其对髓核（NP）细胞的作用
确定其对骨代谢的影响，如成骨分化、抑制破骨细胞形成。

Naringin has been used:
• as a bitter tastant to compare the behavioral response of the Drosophila larva and adult
• to study its anti-inflammatory property and to determine its effect on nucleus pulposus (NP) cells
• to determine its effect on bone metabolism like osteogenic differentiation, inhibition of osteoclast formation
纯度 ≥95%

关联靶点（人）

SLCO1A2 Tchem 溶质载体有机阴离子转运蛋白家族成员1A2(Solute carrier organic anion transporter family member 1A2) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
F2 Tclin Thrombin (11687 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYP19A1 Tclin Cytochrome P450 19A1 (6099 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
FABP4 Tchem Fatty acid binding protein adipocyte (764 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HPSE Tchem Heparanase (634 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Caco-2 (12174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HepG2 (196354 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Monocyte (474 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UBE2N Tchem Ubiquitin-conjugating enzyme E2 N (1570 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BCL2A1 Tchem Bcl-2-related protein A1 (291 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT2B15 Tbio UDP-glucuronosyltransferase 2B15 (172 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 (448 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERG Tbio Transcriptional regulator ERG (5589 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO1A2 Tchem Solute carrier organic anion transporter family member 1A2 (104 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SLCO2B1 Tchem Solute carrier organic anion transporter family member 2B1 (580 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CYCS Tchem Cytochrome c (68 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNJ3 Tchem Kir3.1/Kir3.4 (583 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KCNJ3 Tchem Kir3.1/Kir3.2 (445 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

ampC Beta-lactamase AmpC (62480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Abcb1b P-glycoprotein 1 (174 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hdac6 Histone deacetylase 6 (222 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Pseudomonas aeruginosa (123386 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Salmonella typhimurium (15756 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Aggregatibacter actinomycetemcomitans (150 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Porphyromonas gingivalis (651 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RAW264.7 (28094 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
rep Replicase polyprotein 1ab (378 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Trpa1 Transient receptor potential cation channel subfamily A member 1 (1003 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
BCHE Cholinesterase (8742 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Slco1a5 Solute carrier organic anion transporter family member 1A5 (48 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Thoracic aorta (838 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

PubChem SID 488189790
EC号 233-566-4
分子类型 小分子
IIUPAC Name (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
INCHI 1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
InChi Key DFPMSGMNTNDNHN-ZPHOTFPESA-N
Smiles CC1C(C(C(C(O1)OC2C(C(C(OC2OC3=CC(=C4C(=O)CC(OC4=C3)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O
Isomeric SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=CC(=C4C(=O)C[C@H](OC4=C3)C5=CC=C(C=C5)O)O)CO)O)O)O)O)O
分子量 580.53
Beilstein号 102012
Reaxy-Rn 25075985
Reaxys-RN link address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25075985&ln=

化学和物理性质

溶解性 Soluble in water, alcohol, acetone and warm acetic acid
密度 1.66
敏感性 对湿度敏感
比旋光度 -84 ° (C=2, EtOH)
熔点 166℃
分子量 580.500 g/mol
XLogP3 -0.500
氢键供体数Hydrogen Bond Donor Count 8
氢键受体数Hydrogen Bond Acceptor Count 14
可旋转键计数Rotatable Bond Count 6
精确质量Exact Mass 580.179 Da
单同位素质量Monoisotopic Mass 580.179 Da
拓扑极表面积Topological Polar Surface Area 225.000 Ų
重原子数Heavy Atom Count 41
形式电荷Formal Charge 0
复杂度Complexity 884.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 11
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 警告
危险声明

H315: 引起皮肤刺激

H319: 引起严重眼睛刺激

H335: 可能引起呼吸道刺激
预防措施声明

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾

P264: 处理后要彻底洗手。

P271: 仅在室外或通风良好的地方使用。

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。

P321: 特殊处理（请参阅此标签上的...）。

P302+P352: 如皮肤沾染：用水充分清洗。

P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。

P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。

P405: 密闭存放

P403+P233: 存放在通风良好的地方。保持容器密闭。

P501: 将内容物/容器处理到。。。

P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。

P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。

P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany 3
RTECS QN6340000
Merck Index 6425
个人防护装备 dust mask type N95 (US),Eyeshields,Gloves

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D2426035 分析证书 N107345
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引用文献

1. Chengyun He, Lu Bai, Daqun Liu, Benguo Liu.  (2023)  Interaction mechanism of okra (Abelmoschus esculentus L.) seed protein and flavonoids: Fluorescent and 3D-QSAR studies.  Food Chemistry-X,  20  (101023).  [PMID:38144792] [10.1016/j.fochx.2023.101023]
2. Shucheng Liu, Nana Tang, Xuan Zhang, Hao Huang, Jinyu Li, Hongxiang Ou.  (2024)  Hydrophilic porous boronate imprinted hydrogels for ultrafast transport and highly specific separation of flavoniods: A interfacial cooperative emulsion imprinted strategy based on microreactors.  CHEMICAL ENGINEERING JOURNAL,  479  (147502).  [10.1016/j.cej.2023.147502]
3. Yu Liu, Xinqi Qiu, Minhui Zhang, Yali Lin, Hui Lan, Xican Li, Quanzhou Wu, Jianfeng He.  (2024)  Boronate affinity-based surface molecularly imprinted polymer microspheres using polyethyleneimine/dopamine coating for efficient selective recognition and separation of Ginsenoside Rb1.  REACTIVE & FUNCTIONAL POLYMERS,  194  (105780).  [10.1016/j.reactfunctpolym.2023.105780]
4. Danzhao Guo, Yuying Mao, Xuan Zhang, Bin Bai, Xingchen Yan, Shucheng Liu.  (2024)  Hierarchically porous boronic acid functioned copolymers fabricated from HIPEs microreactor for ultrafast transport and specific recognition of flavonoids.  SEPARATION AND PURIFICATION TECHNOLOGY,  332  (125781).  [10.1016/j.seppur.2023.125781]
5. Shucheng Liu, Zhi Hu, Xuan Zhang, Hao Huang, Jianming Pan, Hongxiang Ou.  (2024)  Fabrication of double imprinted anchor points in cellulose nanocrystals-based hierarchical porous polyHIPEs for selective separation of flavoniods under physiological pH.  JOURNAL OF HAZARDOUS MATERIALS,  465  (133230).  [PMID:38134695] [10.1016/j.jhazmat.2023.133230]
6. Caiying Zhang, Yuelong Li, Abdus Samad, Hongliang He, Huan Ma, Yang Chen, Tengchuan Jin.  (2024)  Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  254  (127856).  [PMID:37924898] [10.1016/j.ijbiomac.2023.127856]
7. Wei Xiong, Lingmei Yuan, Jinyang Huang, Bin Pan, Ling Guo, Guowen Qian, Cijun Shuai, Zhikui Zeng.  (2023)  Direct osteogenesis and immunomodulation dual function via sustained release of naringin in the polymer scaffold.  Journal of Materials Chemistry B,  [PMID:37929928] [10.1039/D3TB01555F]
8. Yuan Meng, Zihao Wei, Changhu Xue.  (2024)  Correlation among molecular structure, air/water interfacial behavior and foam properties of naringin-treated chickpea protein isolates.  FOOD HYDROCOLLOIDS,  147  (109309).  [10.1016/j.foodhyd.2023.109309]
9. Zhi Hu, Shucheng Liu, Nana Tang, Xuan Zhang, Jianming Pan.  (2023)  Hierarchically porous MOFs self-supporting copolymers for ultrafast transport and precise recognition of flavonoids: A triple interfacial crosslinking strategy based on microreactors.  SEPARATION AND PURIFICATION TECHNOLOGY,  326  (124819).  [10.1016/j.seppur.2023.124819]
10. Yuan Meng, Zihao Wei, Changhu Xue.  (2023)  Deciphering the interaction mechanism and binding mode between chickpea protein isolate and flavonoids based on experimental studies and molecular simulation.  FOOD CHEMISTRY,  429  (136848).  [PMID:37454615] [10.1016/j.foodchem.2023.136848]
11. Shucheng Liu, Zhi Hu, Xingchen Yan, Senbai Geng, Xian Zhao, Hongxiang Ou, Jianming Pan.  (2023)  Separation and purification of target flavonoids using covalently connected MOFs@boronic acid-functionalized-COFs magnetic hybrids: Precise identification and enhanced stability.  SEPARATION AND PURIFICATION TECHNOLOGY,  320  (124061).  [10.1016/j.seppur.2023.124061]
12. Lei He, Qian Hu, Liyang Wei, Xuliyang Ge, Ning Yu, Ying Chen.  (2023)  Unravelling dynamic changes in non-volatile and volatile metabolites of pulses during soaking: An integrated metabolomics approach.  FOOD CHEMISTRY,  422  (136231).  [PMID:37141754] [10.1016/j.foodchem.2023.136231]
13. Nan Deng, Xiaofang Bian, Shunjing Luo, Chengmei Liu, Xiuting Hu.  (2023)  The starch-polyphenol inclusion complex: Preparation, characterization and digestion.  Food Bioscience,  53  (102655).  [10.1016/j.fbio.2023.102655]
14. Nan Chen, Hao-Xiang Gao, Qiang He, Wei-Cai Zeng.  (2023)  Potential application of phenolic compounds with different structural complexity in maize starch-based film.  Food Structure-Netherlands,  36  (100318).  [10.1016/j.foostr.2023.100318]
15. Huiqun Fan, Mingshun Chen, Taotao Dai, Lizhen Deng, Chengmei Liu, Wei Zhou, Jun Chen.  (2023)  Phenolic compounds profile of Amomum tsaoko Crevost et Lemaire and their antioxidant and hypoglycemic potential.  Food Bioscience,  52  (102508).  [10.1016/j.fbio.2023.102508]
16. Shengxiang Yi, Gaowei Zhang, Mingyan Liu, Wenjie Yu, Guohua Cheng, Liping Luo, Fangjian Ning.  (2023)  Citrus Honey Ameliorates Liver Disease and Restores Gut Microbiota in Alcohol–Feeding Mice.  Nutrients,  15  (5): (1078).  [PMID:36904078] [10.3390/nu15051078]
17. Ashish Ranjan Sharma, Yeon-Hee Lee, Altanzul Bat-Ulzii, Srijan Chatterjee, Manojit Bhattacharya, Chiranjib Chakraborty, Sang-Soo Lee.  (2023)  Bioactivity, Molecular Mechanism, and Targeted Delivery of Flavonoids for Bone Loss.  Nutrients,  15  (4): (919).  [PMID:36839278] [10.3390/nu15040919]
18. Yang Du, Fengjiao Zhao, Junpeng Xing, Zhiqiang Liu, Meng Cui.  (2023)  Stabilization of Labile Lysozyme–Ligand Interactions in Native Electrospray Ionization Mass Spectrometry.  JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY,  34  (3): (366–373).  [PMID:36735536] [10.1021/jasms.2c00238]
19. Pan Lixia, Ye Hangyu, Pi Xionge, Liu Wei, Wang Zhao, Zhang Yinjun, Zheng Jianyong.  (2023)  Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation.  Frontiers in Microbiology,  14  [PMID:36819019] [10.3389/fmicb.2023.1092729]
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