| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| N101315-100mg |
100mg |
现货  |
| |
| N101315-500mg |
500mg |
现货 |
|
| 别名 | 顺-15-二十四碳烯酸, 鲨油酸 |
|---|---|
| 英文别名 | AMY22585 | BCP28714 | cis-15-Tetracosenate | UNII-91OQS788BE | FA 24:1 | Nervonic acid | SCHEMBL21103 | FA(24:1) | (15e)-Tetracos-15-Enoic Acid | (15Z)-tetracos-15-enoic acid | 91OQS788BE | C08323 | selacholeate | 15-TETRACOSENOIC ACID, CIS- | Nervonic ac |
| 规格或纯度 | 分析标准品, ≥99%(GC) |
| 英文名称 | Nervonic acid |
| 生化机理 | 神经氨酸（C24:1）是膜鞘脂和磷脂酰乙醇胺的一种成分，可能是预测慢性肾病死亡率和糖尿病的有效指标。目前正在研究神经氨酸油在制药、保健品和工业方面的应用。神经氨酸是月见草油的主要成分。 |
| 储存温度 | 避光,-20°C储存,干燥 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
神经酸是棕榈酸、硬脂酸、油酸等多种脂肪酸去饱和化和伸长过程的产物
Nervonic acids are the products of desaturation and elongation processes of various fatty acids such as palmitic acid, stearic acid, oleic acid, etc
|
| 纯度 | ≥99%(GC) |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (Z)-tetracos-15-enoic acid |
| INCHI | 1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9- |
| InChi Key | GWHCXVQVJPWHRF-KTKRTIGZSA-N |
| Smiles | CCCCCCCCC=CCCCCCCCCCCCCCC(=O)O |
| Isomeric SMILES | CCCCCCCC/C=C\CCCCCCCCCCCCCC(=O)O |
| 分子量 | 366.62 |
| Beilstein号 | 1728551 |
| Reaxy-Rn | 11340885 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11340885&ln= |
| 密度 | 0.887 |
|---|---|
| 敏感性 | 对湿度敏感；对光线敏感 |
| 闪点(℉) | 110 °C |
| 闪点(℃) | 110°C |
| 熔点 | 42-43°C |
| 分子量 | 366.600 g/mol |
| XLogP3 | 9.800 |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 21 |
| 精确质量Exact Mass | 366.35 Da |
| 单同位素质量Monoisotopic Mass | 366.35 Da |
| 拓扑极表面积Topological Polar Surface Area | 37.300 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 309.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 1 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 1 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| WGK Germany | 3 |
| 个人防护装备 | dust mask type N95 (US),Eyeshields,Gloves |
| 1. Y Mizushina,F Sugawara,A Iida,K Sakaguchi. (2000-11-25) Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II.. Journal of molecular biology, 304 ((3)): (385-395). [PMID:11090281] |
| 2. Inderjit Singh. (2002-07-20) Peroxisomal fatty acid oxidation and cellular redox.. Methods in enzymology, 352 (361-372). [PMID:12125363] |
| 3. Nobuyuki Kasai,Yoshiyuki Mizushina,Fumio Sugawara,Kengo Sakaguchi. (2002-11-06) Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase beta and HIV-1 reverse transcriptase.. Journal of biochemistry, 132 ((5)): (819-828). [PMID:12417034] |
| 4. Marie-Elisabeth Agazzi,Andrea Bau,Robertino Barcarolo,Ernst Luecker,Josefa Barrero-Moreno,Elke Anklam. (2003-05-07) In-house validation of an improved sample extraction and clean-up method for GC determination of isomers of nervonic acid in meat products.. Analytical and bioanalytical chemistry, 376 ((3)): (360-365). [PMID:12732919] |
| 5. William J Bettger,Edith DiMichelle-Ranalli,Barbara Dillingham,Clarke B Blackadar. (2003-05-14) Nervonic acid is transferred from the maternal diet to milk and tissues of suckling rat pups.. The Journal of nutritional biochemistry, 14 ((3)): (160-165). [PMID:12742544] |
| 6. Earl Weidner,Ann Findley. (2003-10-30) Catalase in microsporidian spores before and during discharge.. The Biological bulletin, 205 ((2)): (236-237). [PMID:14583549] |
| 7. Aleix Sala-Vila,Ana I Castellote,Cristina Campoy,Montserrat Rivero,María Rodriguez-Palmero,M Carmen López-Sabater. (2004-03-31) The source of long-chain PUFA in formula supplements does not affect the fatty acid composition of plasma lipids in full-term infants.. The Journal of nutrition, 134 ((4)): (868-873). [PMID:15051839] |
| 8. Ann M Findley,Earl H Weidner,Kevin R Carman,Zhimin Xu,J Samuel Godbar. (2005-07-12) Role of the posterior vacuole in Spraguea lophii (Microsporidia) spore hatching.. Folia parasitologica, 52 ((1-2)): (111-117). [PMID:16004370] |
| 9. Nobuyuki Kasai,Yoshiyuki Mizushina,Hiroshi Murata,Takayuki Yamazaki,Tadayasu Ohkubo,Kengo Sakaguchi,Fumio Sugawara. (2005-09-01) Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase beta.. The FEBS journal, 272 ((17)): (4349-4361). [PMID:16128805] |
| 10. Eiji Oda,Katsuharu Hatada,Jun Kimura,Yoshifusa Aizawa,Punniyakoti Veeraveedu Thanikachalam,Kenichi Watanabe. (2006-01-06) Relationships between serum unsaturated fatty acids and coronary risk factors: negative relations between nervonic acid and obesity-related risk factors.. International heart journal, 46 ((6)): (975-985). [PMID:16394593] |
| 11. M Laasonen,A T Erkkilä,E Isotalo,P K Mäenpää,J J Pulkkinen,V Virsu,M-L Haapanen. (2006-03-21) Serum lipid fatty acids and temporal processing acuity in children with oral clefts.. Prostaglandins, leukotrienes, and essential fatty acids, 74 ((4)): (263-270). [PMID:16545557] |
| 12. B Singh,B K Chandan,N Sharma,V Bhardwaj,N K Satti,V N Gupta,B D Gupta,K A Suri,O P Suri. (2006-07-15) Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.. Phytotherapy research : PTR, 20 ((10)): (831-839). [PMID:16841368] |
| 13. Martin Karlsson,Staffan Mårild,John Brandberg,Lars Lönn,Peter Friberg,Birgitta Strandvik. (2006-12-01) Serum phospholipid fatty acids, adipose tissue, and metabolic markers in obese adolescents.. Obesity (Silver Spring, Md.), 14 ((11)): (1931-1939). [PMID:17135608] |
| 14. Ersin Odabasi,Husamettin Gul,Enis Macit,Mustafa Turan,Oguzhan Yildiz. (2008-01-02) Lipophilic components of different therapeutic mud species.. Journal of alternative and complementary medicine (New York, N.Y.), 13 ((10)): (1115-1118). [PMID:18166123] |
| 15. David S Wishart,Craig Knox,An Chi Guo,Roman Eisner,Nelson Young,Bijaya Gautam,David D Hau,Nick Psychogios,Edison Dong,Souhaila Bouatra,Rupasri Mandal,Igor Sinelnikov,Jianguo Xia,Leslie Jia,Joseph A Cruz,Emilia Lim,Constance A Sobsey,Savita Shrivastava,Paul Huang,Philip Liu,Lydia Fang,Jun Peng,Ryan Fradette,Dean Cheng,Dan Tzur,Melisa Clements,Avalyn Lewis,Andrea De Souza,Azaret Zuniga,Margot Dawe,Yeping Xiong,Derrick Clive,Russ Greiner,Alsu Nazyrova,Rustem Shaykhutdinov,Liang Li,Hans J Vogel,Ian Forsythe. (2008-10-28) HMDB: a knowledgebase for the human metabolome.. Nucleic acids research, 37 ((Database issue)): (D603-D610). [PMID:18953024] |
| 16. Yiming Guo,Elzbieta Mietkiewska,Tammy Francis,Vesna Katavic,Jennifer M Brost,Michael Giblin,Dennis L Barton,David C Taylor. (2008-12-17) Increase in nervonic acid content in transformed yeast and transgenic plants by introduction of a Lunaria annua L. 3-ketoacyl-CoA synthase (KCS) gene.. Plant molecular biology, 69 ((5)): (565-575). [PMID:19082744] |
| 17. Jun Yang,Jing Yang,Zheng-Qin Yin,Jing Xu,Ning Hu,I Svir,Min Wang,Yuan-Yi Li,Lei Zhan,Song Wu,Xiao-Lin Zheng. (2009-09-15) Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta.. Biochemistry. Biokhimiia, 74 ((7)): (813-818). [PMID:19747104] |
| 18. David C Taylor,Tammy Francis,Yiming Guo,Jennifer M Brost,Vesna Katavic,Elzbieta Mietkiewska,E Michael Giblin,Sharla Lozinsky,Travis Hoffman. (2009-10-22) Molecular cloning and characterization of a KCS gene from Cardamine graeca and its heterologous expression in Brassica oilseeds to engineer high nervonic acid oils for potential medical and industrial use.. Plant biotechnology journal, 7 ((9)): (925-938). [PMID:19843251] |
| 19. Aurore Vluggens,Pierre Andreoletti,Navin Viswakarma,Yuzhi Jia,Kojiro Matsumoto,Wim Kulik,Mushfiquddin Khan,Jiansheng Huang,Dongsheng Guo,Sangtao Yu,Joy Sarkar,Inderjit Singh,M Sambasiva Rao,Ronald J Wanders,Janardan K Reddy,Mustapha Cherkaoui-Malki. (2010-03-03) Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].. Laboratory investigation; a journal of technical methods and pathology, 90 ((5)): (696-708). [PMID:20195242] |
| 20. Yunbao Liu,Muraleedharan G Nair. (2010-06-23) An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.. Journal of natural products, 73 ((7)): (1193-1195). [PMID:20565070] |
| 21. Oswald Quehenberger,Aaron M Armando,Alex H Brown,Stephen B Milne,David S Myers,Alfred H Merrill,Sibali Bandyopadhyay,Kristin N Jones,Samuel Kelly,Rebecca L Shaner,Cameron M Sullards,Elaine Wang,Robert C Murphy,Robert M Barkley,Thomas J Leiker,Christian R H Raetz,Ziqiang Guan,Gregory M Laird,David A Six,David W Russell,Jeffrey G McDonald,Shankar Subramaniam,Eoin Fahy,Edward A Dennis. (2010-07-31) Lipidomics reveals a remarkable diversity of lipids in human plasma.. Journal of lipid research, 51 ((11)): (3299-3305). [PMID:20671299] |
| 22. Giuseppe Impallomeni,Alberto Ballistreri,Giovanni Marco Carnemolla,Salvatore P P Guglielmino,Marco Sebastiano Nicolò,Maria Grazia Cambria. (2010-11-03) Synthesis and characterization of poly(3-hydroxyalkanoates) from Brassica carinata oil with high content of erucic acid and from very long chain fatty acids.. International journal of biological macromolecules, 48 ((1)): (137-145). [PMID:21035502] |
| 23. Nikolaos Psychogios,David D Hau,Jun Peng,An Chi Guo,Rupasri Mandal,Souhaila Bouatra,Igor Sinelnikov,Ramanarayan Krishnamurthy,Roman Eisner,Bijaya Gautam,Nelson Young,Jianguo Xia,Craig Knox,Edison Dong,Paul Huang,Zsuzsanna Hollander,Theresa L Pedersen,Steven R Smith,Fiona Bamforth,Russ Greiner,Bruce McManus,John W Newman,Theodore Goodfriend,David S Wishart. (2011-03-02) The human serum metabolome.. PloS one, 6 ((2)): (e16957-e16957). [PMID:21359215] |
| 24. Gregory C Shearer,Juan J Carrero,Olof Heimbürger,Peter Barany,Peter Stenvinkel. (2011-07-22) Plasma fatty acids in chronic kidney disease: nervonic acid predicts mortality.. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 22 ((2)): (277-283). [PMID:21775161] |
| 25. Madhavi V Dhobale,Nisha Wadhwani,Savita S Mehendale,Hemlata R Pisal,Sadhana R Joshi. (2011-08-06) Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries.. Prostaglandins, leukotrienes, and essential fatty acids, 85 ((3-4)): (149-153). [PMID:21816593] |
| 26. G P Amminger,M R Schäfer,C M Klier,J-M Slavik,I Holzer,M Holub,S Goldstone,T J Whitford,P D McGorry,M Berk. (2011-12-21) Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seeking ultra-high-risk individuals.. Molecular psychiatry, 17 ((12)): (1150-1152). [PMID:22182937] |
| 27. S Snigdha,G Astarita,D Piomelli,C W Cotman. (2011-12-21) Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain.. Neuroscience, 202 (326-333). [PMID:22183056] |
| 28. Dong Chang,Shengzhong Rong,Yannan Zhang,Qian Sha,Meihua Liang,Xuefei Zhang,Miaojing Li,Hongzhi Pan. (2014-08-01) Serum free fatty acids level in senile cataract.. Journal of the American College of Nutrition, 33 ((5)): (406-411). [PMID:25079310] |
| 29. Guan-yuan Chen,Huai-hsuan Chiu,Shu-wen Lin,Yufeng Jane Tseng,Sung-jeng Tsai,Ching-hua Kuo. (2014-08-26) Development and application of a comparative fatty acid analysis method to investigate voriconazole-induced hepatotoxicity.. Clinica chimica acta; international journal of clinical chemistry, 438 (126-134). [PMID:25150729] |
| 30. J R Sargent,K Coupland,R Wilson. (1994-04-01) Nervonic acid and demyelinating disease.. Medical hypotheses, 42 ((4)): (237-242). [PMID:8072429] |
| 31. L Zhou,J Hou,H Fan. (2003-01-29) [Determination of nervonic acid in oral tonic by GC].. Se pu = Chinese journal of chromatography, 17 ((3)): (306-307). [PMID:12549137] |
| 32. Jiun-Rong Chen,Shiou-Fung Hsu,Cheng-Dien Hsu,Lih-Hsueh Hwang,Suh-Ching Yang. (2004-08-11) Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan.. The Journal of nutritional biochemistry, 15 ((8)): (467-472). [PMID:15302081] |
| 33. Arja T Erkkilä,Elina Isotalo,Joonas Pulkkinen,Marja-Leena Haapanen. (2005-09-30) Association between school performance, breast milk intake and fatty acid profile of serum lipids in ten-year-old cleft children.. The Journal of craniofacial surgery, 16 ((5)): (764-769). [PMID:16192854] |
| 34. Demetris Bitsanis,Michael A Crawford,Therishnee Moodley,Holm Holmsen,Kebreab Ghebremeskel,Ovrang Djahanbakhch. (2005-10-28) Arachidonic acid predominates in the membrane phosphoglycerides of the early and term human placenta.. The Journal of nutrition, 135 ((11)): (2566-2571). [PMID:16251612] |
| 35. Shizuka Murakami,Shinji Kamisuki,Kei-ichi Takata,Nobuyuki Kasai,Seisuke Kimura,Yoshiyuki Mizushina,Keisuke Ohta,Fumio Sugawara,Kengo Sakaguchi. (2006-09-26) Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8 kDa domain of DNA polymerase beta.. Biochemical and biophysical research communications, 350 ((1)): (7-16). [PMID:16996474] |
| 36. Assunta Zanfini,Elena Dreassi,Anna Berardi,Paola Piomboni,Elvira Costantino-Ceccarini,Alice Luddi. (2014-09-12) GC-EI-MS analysis of fatty acid composition in brain and serum of twitcher mouse.. Lipids, 49 ((11)): (1115-1125). [PMID:25208498] |
| 37. Jie Cheng, Yuling Li, Yunjun Wang, Jing Zhang, Tuanqi Sun, Li Zhang, Yinlong Guo. (2022) Quaterization Derivatization with Bis(Pyridine) Iodine Tetrafluoroboride: High-Sensitivity Mass Spectrometric Analysis of Unsaturated Fatty Acids in Human Thyroid Tissues. ANALYTICAL CHEMISTRY, 94 (32): (11185–11191). [PMID:35916214] [10.1021/acs.analchem.2c01519] |
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