基本描述

别名	顺-15-二十四碳烯酸, 鲨油酸
英文别名	AMY22585 \| BCP28714 \| cis-15-Tetracosenate \| UNII-91OQS788BE \| FA 24:1 \| Nervonic acid \| SCHEMBL21103 \| FA(24:1) \| (15e)-Tetracos-15-Enoic Acid \| (15Z)-tetracos-15-enoic acid \| 91OQS788BE \| C08323 \| selacholeate \| 15-TETRACOSENOIC ACID, CIS- \| Nervonic ac
规格或纯度	≥95%(GC)
英文名称	Nervonic acid
生化机理	神经酸（C24:1）是膜鞘脂和磷脂酰乙醇胺的成分，它可能是慢性肾病死亡率和糖尿病的有效预测因子。目前正在研究神经酸油在制药、营养品和工业中的应用。神经酸是Lunaria油的主要成分。单不饱和ω-9长链脂肪酸。在过氧化物酶体中被β-氧化。髓鞘生物合成和CNS鞘脂的结构成分。肾上腺皮质营养不良。口服具有活性
储存温度	-20°C储存,充氩
运输条件	超低温冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	神经酸已被用作体外合成的脂质补充剂，用于研究发育饮食对果蝇寿命的影响。 Nervonic acid has been used as a synthetic lipid supplement in vitro to study about effect of the developmental diet in Drosophila lifespan.
纯度	≥95%(GC)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

名称和识别符

PubChem SID	504763335
分子类型	小分子
IIUPAC Name	(Z)-tetracos-15-enoic acid
INCHI	1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/b10-9-
InChi Key	GWHCXVQVJPWHRF-KTKRTIGZSA-N
Smiles	CCCCCCCCC=CCCCCCCCCCCCCCC(=O)O
Isomeric SMILES	CCCCCCCC/C=C\CCCCCCCCCCCCCC(=O)O
分子量	366.62
Beilstein号	1728551
Reaxy-Rn	11340885
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=11340885&ln=

化学和物理性质

溶解性	Insoluble in water；DMSO：79 mg/mL；Ethanol：79 mg/mL
密度	0.887
敏感性	对空气敏感；对光线敏感
闪点(℉)	110 °C
闪点(℃)	110°C
熔点	42-43°C
分子量	366.600 g/mol
XLogP3	9.800
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	2
可旋转键计数Rotatable Bond Count	21
精确质量Exact Mass	366.35 Da
单同位素质量Monoisotopic Mass	366.35 Da
拓扑极表面积Topological Polar Surface Area	37.300 Å²
重原子数Heavy Atom Count	26
形式电荷Formal Charge	0
复杂度Complexity	309.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	1
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	1
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

象形图	GHS07
信号词	警告
危险声明	H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。
WGK Germany	3
个人防护装备	dust mask type N95 (US),Eyeshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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找到11个结果

批号(Lot Number)	证书类型	货号
I2108348	分析证书	N141402
K2321177	分析证书	N141402
K2321526	分析证书	N141402
K2321527	分析证书	N141402
K2321537	分析证书	N141402
D2222135	分析证书	N141402
D2222136	分析证书	N141402
B2208440	分析证书	N141402
B2208445	分析证书	N141402
B2208504	分析证书	N141402
B2208505	分析证书	N141402

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此产品的引用文献

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引用文献

1. Y Mizushina,F Sugawara,A Iida,K Sakaguchi. (2000-11-25) Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II.. Journal of molecular biology, 304 ((3)): (385-395). [PMID:11090281]
2. Inderjit Singh. (2002-07-20) Peroxisomal fatty acid oxidation and cellular redox.. Methods in enzymology, 352 (361-372). [PMID:12125363]
3. Nobuyuki Kasai,Yoshiyuki Mizushina,Fumio Sugawara,Kengo Sakaguchi. (2002-11-06) Three-dimensional structural model analysis of the binding site of an inhibitor, nervonic acid, of both DNA polymerase beta and HIV-1 reverse transcriptase.. Journal of biochemistry, 132 ((5)): (819-828). [PMID:12417034]
4. Marie-Elisabeth Agazzi,Andrea Bau,Robertino Barcarolo,Ernst Luecker,Josefa Barrero-Moreno,Elke Anklam. (2003-05-07) In-house validation of an improved sample extraction and clean-up method for GC determination of isomers of nervonic acid in meat products.. Analytical and bioanalytical chemistry, 376 ((3)): (360-365). [PMID:12732919]
5. William J Bettger,Edith DiMichelle-Ranalli,Barbara Dillingham,Clarke B Blackadar. (2003-05-14) Nervonic acid is transferred from the maternal diet to milk and tissues of suckling rat pups.. The Journal of nutritional biochemistry, 14 ((3)): (160-165). [PMID:12742544]
6. Earl Weidner,Ann Findley. (2003-10-30) Catalase in microsporidian spores before and during discharge.. The Biological bulletin, 205 ((2)): (236-237). [PMID:14583549]
7. Aleix Sala-Vila,Ana I Castellote,Cristina Campoy,Montserrat Rivero,María Rodriguez-Palmero,M Carmen López-Sabater. (2004-03-31) The source of long-chain PUFA in formula supplements does not affect the fatty acid composition of plasma lipids in full-term infants.. The Journal of nutrition, 134 ((4)): (868-873). [PMID:15051839]
8. Ann M Findley,Earl H Weidner,Kevin R Carman,Zhimin Xu,J Samuel Godbar. (2005-07-12) Role of the posterior vacuole in Spraguea lophii (Microsporidia) spore hatching.. Folia parasitologica, 52 ((1-2)): (111-117). [PMID:16004370]
9. Nobuyuki Kasai,Yoshiyuki Mizushina,Hiroshi Murata,Takayuki Yamazaki,Tadayasu Ohkubo,Kengo Sakaguchi,Fumio Sugawara. (2005-09-01) Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase beta.. The FEBS journal, 272 ((17)): (4349-4361). [PMID:16128805]
10. Eiji Oda,Katsuharu Hatada,Jun Kimura,Yoshifusa Aizawa,Punniyakoti Veeraveedu Thanikachalam,Kenichi Watanabe. (2006-01-06) Relationships between serum unsaturated fatty acids and coronary risk factors: negative relations between nervonic acid and obesity-related risk factors.. International heart journal, 46 ((6)): (975-985). [PMID:16394593]
11. M Laasonen,A T Erkkilä,E Isotalo,P K Mäenpää,J J Pulkkinen,V Virsu,M-L Haapanen. (2006-03-21) Serum lipid fatty acids and temporal processing acuity in children with oral clefts.. Prostaglandins, leukotrienes, and essential fatty acids, 74 ((4)): (263-270). [PMID:16545557]
12. B Singh,B K Chandan,N Sharma,V Bhardwaj,N K Satti,V N Gupta,B D Gupta,K A Suri,O P Suri. (2006-07-15) Isolation, structure elucidation and in vivo hepatoprotective potential of trans-tetracos-15-enoic acid from Indigofera tinctoria Linn.. Phytotherapy research : PTR, 20 ((10)): (831-839). [PMID:16841368]
13. Martin Karlsson,Staffan Mårild,John Brandberg,Lars Lönn,Peter Friberg,Birgitta Strandvik. (2006-12-01) Serum phospholipid fatty acids, adipose tissue, and metabolic markers in obese adolescents.. Obesity (Silver Spring, Md.), 14 ((11)): (1931-1939). [PMID:17135608]
14. Yiming Guo,Elzbieta Mietkiewska,Tammy Francis,Vesna Katavic,Jennifer M Brost,Michael Giblin,Dennis L Barton,David C Taylor. (2008-12-17) Increase in nervonic acid content in transformed yeast and transgenic plants by introduction of a Lunaria annua L. 3-ketoacyl-CoA synthase (KCS) gene.. Plant molecular biology, 69 ((5)): (565-575). [PMID:19082744]
15. Jun Yang,Jing Yang,Zheng-Qin Yin,Jing Xu,Ning Hu,I Svir,Min Wang,Yuan-Yi Li,Lei Zhan,Song Wu,Xiao-Lin Zheng. (2009-09-15) Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta.. Biochemistry. Biokhimiia, 74 ((7)): (813-818). [PMID:19747104]
16. Aurore Vluggens,Pierre Andreoletti,Navin Viswakarma,Yuzhi Jia,Kojiro Matsumoto,Wim Kulik,Mushfiquddin Khan,Jiansheng Huang,Dongsheng Guo,Sangtao Yu,Joy Sarkar,Inderjit Singh,M Sambasiva Rao,Ronald J Wanders,Janardan K Reddy,Mustapha Cherkaoui-Malki. (2010-03-03) Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].. Laboratory investigation; a journal of technical methods and pathology, 90 ((5)): (696-708). [PMID:20195242]
17. Yunbao Liu,Muraleedharan G Nair. (2010-06-23) An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.. Journal of natural products, 73 ((7)): (1193-1195). [PMID:20565070]
18. Oswald Quehenberger,Aaron M Armando,Alex H Brown,Stephen B Milne,David S Myers,Alfred H Merrill,Sibali Bandyopadhyay,Kristin N Jones,Samuel Kelly,Rebecca L Shaner,Cameron M Sullards,Elaine Wang,Robert C Murphy,Robert M Barkley,Thomas J Leiker,Christian R H Raetz,Ziqiang Guan,Gregory M Laird,David A Six,David W Russell,Jeffrey G McDonald,Shankar Subramaniam,Eoin Fahy,Edward A Dennis. (2010-07-31) Lipidomics reveals a remarkable diversity of lipids in human plasma.. Journal of lipid research, 51 ((11)): (3299-3305). [PMID:20671299]
19. Giuseppe Impallomeni,Alberto Ballistreri,Giovanni Marco Carnemolla,Salvatore P P Guglielmino,Marco Sebastiano Nicolò,Maria Grazia Cambria. (2010-11-03) Synthesis and characterization of poly(3-hydroxyalkanoates) from Brassica carinata oil with high content of erucic acid and from very long chain fatty acids.. International journal of biological macromolecules, 48 ((1)): (137-145). [PMID:21035502]
20. Gregory C Shearer,Juan J Carrero,Olof Heimbürger,Peter Barany,Peter Stenvinkel. (2011-07-22) Plasma fatty acids in chronic kidney disease: nervonic acid predicts mortality.. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 22 ((2)): (277-283). [PMID:21775161]
21. Madhavi V Dhobale,Nisha Wadhwani,Savita S Mehendale,Hemlata R Pisal,Sadhana R Joshi. (2011-08-06) Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries.. Prostaglandins, leukotrienes, and essential fatty acids, 85 ((3-4)): (149-153). [PMID:21816593]
22. G P Amminger,M R Schäfer,C M Klier,J-M Slavik,I Holzer,M Holub,S Goldstone,T J Whitford,P D McGorry,M Berk. (2011-12-21) Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seeking ultra-high-risk individuals.. Molecular psychiatry, 17 ((12)): (1150-1152). [PMID:22182937]
23. S Snigdha,G Astarita,D Piomelli,C W Cotman. (2011-12-21) Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain.. Neuroscience, 202 (326-333). [PMID:22183056]
24. Dong Chang,Shengzhong Rong,Yannan Zhang,Qian Sha,Meihua Liang,Xuefei Zhang,Miaojing Li,Hongzhi Pan. (2014-08-01) Serum free fatty acids level in senile cataract.. Journal of the American College of Nutrition, 33 ((5)): (406-411). [PMID:25079310]
25. J R Sargent,K Coupland,R Wilson. (1994-04-01) Nervonic acid and demyelinating disease.. Medical hypotheses, 42 ((4)): (237-242). [PMID:8072429]
26. L Zhou,J Hou,H Fan. (2003-01-29) [Determination of nervonic acid in oral tonic by GC].. Se pu = Chinese journal of chromatography, 17 ((3)): (306-307). [PMID:12549137]
27. Arja T Erkkilä,Elina Isotalo,Joonas Pulkkinen,Marja-Leena Haapanen. (2005-09-30) Association between school performance, breast milk intake and fatty acid profile of serum lipids in ten-year-old cleft children.. The Journal of craniofacial surgery, 16 ((5)): (764-769). [PMID:16192854]
28. Shizuka Murakami,Shinji Kamisuki,Kei-ichi Takata,Nobuyuki Kasai,Seisuke Kimura,Yoshiyuki Mizushina,Keisuke Ohta,Fumio Sugawara,Kengo Sakaguchi. (2006-09-26) Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8 kDa domain of DNA polymerase beta.. Biochemical and biophysical research communications, 350 ((1)): (7-16). [PMID:16996474]
29. Todd E Fox,Maria C Bewley,Kellee A Unrath,Michelle M Pedersen,Robert E Anderson,Dae Young Jung,Leonard S Jefferson,Jason K Kim,Sarah K Bronson,John M Flanagan,Mark Kester. (2010-11-12) Circulating sphingolipid biomarkers in models of type 1 diabetes.. Journal of lipid research, 52 ((3)): (509-517). [PMID:21068007]
30. Jie Cheng, Yuling Li, Yunjun Wang, Jing Zhang, Tuanqi Sun, Li Zhang, Yinlong Guo. (2022) Quaterization Derivatization with Bis(Pyridine) Iodine Tetrafluoroboride: High-Sensitivity Mass Spectrometric Analysis of Unsaturated Fatty Acids in Human Thyroid Tissues. ANALYTICAL CHEMISTRY, 94 (32): (11185–11191). [PMID:35916214] [10.1021/acs.analchem.2c01519]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

=

浓度

x

体积

x

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

x

体积 1 (V1)

=

浓度 2 (C2)

x

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

=

质量（小瓶）

÷

所需的复溶浓度

货号 (SKU)	包装规格	是否现货
N141402-250mg	250mg	现货
N141402-1g	1g	现货
N141402-5g	5g	现货
N141402-10g	10g	现货

神经酸

库存信息

库存信息

库存信息

库存信息

基本描述

作用机制

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

显示更多⌵

此产品的引用文献

引用文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器