| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M656496-1ml |
1ml |
期货  |
|
| 规格或纯度 | 10mM in Ethanol |
|---|---|
| 英文名称 | MZP-54 |
| 生化机理 | MZP-54 是一种与 von Hippel-Lindau 和 BRD3/4 配体相连的 PROTAC，对 Brd4 BD2 的 K d 为 4 nM。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
MZP-54 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4 , with a K d of 4 nM for Brd4 BD2 . In Vitro MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a K d of 4 nM for Brd4 BD2 . MZP-54 binds to VHL-EloC-EloB protein (VCB) with a K d of 105 ± 24 nM. MZP-54 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC 50 s of 7.08 ± 0.05 and 6.37 ± 0.03, respectively. MZP-54 also exhibits high depletion of cMyc levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:VHL BRD4 BD2 4 nM (Kd) |
| 分子类型 | 小分子 |
|---|---|
| Isomeric SMILES | C[C@H]1C[C@H](C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)NC7=CC=C(C=C7)Cl |
| 关联CAS | 2010159-47-2 |
| PubChem CID | 122551841 |
| 分子量 | 1036.67 |
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