| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M656113-1ml |
1ml |
期货  |
|
| 别名 | 米萨科拉特 |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Mizacorat |
| 生化机理 | Mizacorat（AZD9567；化合物 15）是一种强效的口服活性非甾体选择性糖皮质激素受体调节剂（SGRM），IC 50 为 3.8 nM。在链球菌细胞壁（SCW）再活化关节炎模型中表现出卓越的疗效 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 调节剂 |
| 产品介绍 |
Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM) , with an IC 50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation In Vivo Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW . Dosage: 15 mg/kg/day. Administration: Oral gavage daily for 8 days. Result: Inhibited ankle swelling in the rat SCW model. IC50& Target:IC50: 3.8 nM (Glucocorticoid receptor) |
| Isomeric SMILES | CC(C)[C@@H]([C@@H](C1=CC=CC=C1)OC2=CC3=C(C=C2)N(N=C3)C4=CN(C(=O)C=C4)C)NC(=O)C(C)(F)F |
|---|---|
| 关联CAS | 1893415-00-3 |
| PubChem CID | 121248172 |
| MeSH Entry Terms | AZD-9567;AZD9567 |
| 分子量 | 494.53 |
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