| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M647781-5mg |
5mg |
期货  |
|
| 别名 | 莫拉辛O |
|---|---|
| 英文别名 | DTXSID201317614 | 1,3-Benzenediol, 5-[(6R)-5,6-dihydro-6-(1-hydroxy-1-methylethyl)benzo[1,2-b:5,4-b']difuran-2-yl]- | MoracinO | 5-[(6R)-6-(2-hydroxypropan-2-yl)-5,6-dihydrofuro[3,2-f][1]benzofuran-2-yl]benzene-1,3-diol | BDBM50346796 | Moracin O | (-)-Mo |
| 规格或纯度 | ≥99% |
| 英文名称 | Moracin O |
| 生化机理 | Moracin O 是一种从桑树中分离出来的 2-芳基苯并呋喃。Moracin O 在体外对缺氧诱导因子（HIF-1）有很强的抑制活性。Moracin O 可减少氧-葡萄糖剥夺（OGD）诱导的活性氧（ROS）。 |
| 储存温度 | 2-8°C储存,避光 |
| 运输条件 | 冰袋运输 |
| 作用类型 | 抑制剂 |
| 产品介绍 |
Moracin O is a 2-arylbenzofuran isolated from the Morus alba Linn.. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects . In Vitro Moracin O enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC 50 value of 12.6 μM. Moracin O reduces ROS production in OGD-induced cell death (IC 50 value of 0.3 μM). Moracin O protects neuronal cell death against the oxidative stress induced by OGD. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| 纯度 | ≥99% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| EC号 | 826-029-6 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 5-[(6R)-6-(2-hydroxypropan-2-yl)-5,6-dihydrofuro[3,2-f][1]benzofuran-2-yl]benzene-1,3-diol |
| INCHI | 1S/C19H18O5/c1-19(2,22)18-7-11-3-10-6-15(23-16(10)9-17(11)24-18)12-4-13(20)8-14(21)5-12/h3-6,8-9,18,20-22H,7H2,1-2H3/t18-/m1/s1 |
| InChi Key | HMTMYIWMPJSCAZ-GOSISDBHSA-N |
| Smiles | CC(C)(C1CC2=C(O1)C=C3C(=C2)C=C(O3)C4=CC(=CC(=C4)O)O)O |
| Isomeric SMILES | CC(C)([C@H]1CC2=C(O1)C=C3C(=C2)C=C(O3)C4=CC(=CC(=C4)O)O)O |
| 关联CAS | 123702-97-6 |
| PubChem CID | 42604718 |
| MeSH Entry Terms | moracin O |
| 分子量 | 326.34 |
| 分子量 | 326.300 g/mol |
|---|---|
| XLogP3 | 3.300 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 2 |
| 精确质量Exact Mass | 326.115 Da |
| 单同位素质量Monoisotopic Mass | 326.115 Da |
| 拓扑极表面积Topological Polar Surface Area | 83.100 Ų |
| 重原子数Heavy Atom Count | 24 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 457.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 1 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
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