| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M477446-100mg |
100mg |
现货  |
|
| 别名 | 2-氨基-3-(1H-吲哚-3-基)-2-甲基丙酸 |
|---|---|
| 英文别名 | DL-alpha-Methyltryptophan | 2-amino-3-(1H-indol-3-yl)-2-methylpropanoic acid | alpha-Methyl-DL-tryptophan | alpha-methyl-D,L-tryptophan |
| 规格或纯度 | ≥98% |
| 英文名称 | α-Methyl-DL-tryptophan |
| 生化机理 | α-甲基-DL-色氨酸是ATBo的阻滞剂，ATBo是一种氨基酸转运蛋白，其表达在癌症中上调。 |
| 储存温度 | 2-8°C储存,避光,充氩 |
| 运输条件 | 冰袋运输 |
| 纯度 | ≥98% |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| PubChem SID | 504756268 |
|---|---|
| 分子类型 | 小分子 |
| IIUPAC Name | 2-amino-3-(1H-indol-3-yl)-2-methylpropanoic acid |
| INCHI | 1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16) |
| InChi Key | ZTTWHZHBPDYSQB-UHFFFAOYSA-N |
| Smiles | CC(CC1=CNC2=CC=CC=C21)(C(=O)O)N |
| Isomeric SMILES | CC(CC1=CNC2=CC=CC=C21)(C(=O)O)N |
| 关联CAS | 153-91-3,13510-08-2 |
| NSC Number | 9948 |
| MeSH Entry Terms | alpha-(11C)methyl-L-tryptophan;alpha-(14C)methyl-tryptophan;alpha-methyl-L-tryptophan;alpha-methyltryptophan;alpha-methyltryptophan, (+)-isomer;alpha-methyltryptophan, (-)-isomer;alpha-methyltryptophan, (D)-isomer;alpha-methyltryptophan, (DL)-isomer;alpha |
| 分子量 | 218.25 |
| Reaxy-Rn | 190962 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=190962&ln= |
| 敏感性 | 对光线敏感 |
|---|---|
| 分子量 | 218.250 g/mol |
| XLogP3 | -0.900 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 3 |
| 可旋转键计数Rotatable Bond Count | 3 |
| 精确质量Exact Mass | 218.106 Da |
| 单同位素质量Monoisotopic Mass | 218.106 Da |
| 拓扑极表面积Topological Polar Surface Area | 79.100 Ų |
| 重原子数Heavy Atom Count | 16 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 282.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 信号词 | 警告 |
|---|---|
| 危险声明 |
H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P271: 仅在室外或通风良好的地方使用。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P363: 再次使用之前，请清洗受污染的衣物。 P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P501: 将内容物/容器处理到。。。 |
| 1. Karunakaran S, Umapathy NS, Thangaraju M, Hatanaka T, Itagaki S, Munn DH, Prasad PD, Ganapathy V. (2008) Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy.. Biochem J, 414 (3): (343-55). [PMID:18522536] |
| 2. Elisabeth Perreau-Linck,Mario Beauregard,Paul Gravel,Vincent Paquette,Jean-Paul Soucy,Mirko Diksic,Chawki Benkelfat. (2007-11-29) In vivo measurements of brain trapping of C-labelled alpha-methyl-L-tryptophan during acute changes in mood states.. Journal of psychiatry & neuroscience : JPN, 32 ((6)): (430-434). [PMID:18043767] |
| 3. Masami Nishikawa,Mirko Diksic,Yojiro Sakai,Hiroaki Kumano,Dara Charney,Jorge Palacios-Boix,Juan Negrete,Kathryn Gill. (2008-11-04) Alterations in brain serotonin synthesis in male alcoholics measured using positron emission tomography.. Alcoholism, clinical and experimental research, 33 ((2)): (233-239). [PMID:18976348] |
| 4. Huixi Zou,Xiaodong Zheng,Shu-Ming Li. (2008-12-31) Substrate promiscuity of the cyclic dipeptide prenyltransferases from Aspergillus fumigatus ( section sign).. Journal of natural products, 72 ((1)): (44-52). [PMID:19113967] |
| 5. Csaba Juhász,Otto Muzik,Xin Lu,M Salik Jahania,Ayman O Soubani,Majid Khalaf,Fangyu Peng,Thomas J Mangner,Pulak K Chakraborty,Diane C Chugani. (2009-02-19) Quantification of tryptophan transport and metabolism in lung tumors using PET.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 50 ((3)): (356-363). [PMID:19223408] |
| 6. Anita S D Saporta,Harry T Chugani,Csaba Juhász,Malek I Makki,Otto Muzik,Benjamin J Wilson,Michael E Behen. (2009-09-15) Multimodality neuroimaging in Tourette syndrome: alpha-[11C] methyl-L-tryptophan positron emission tomography and diffusion tensor imaging studies.. Journal of child neurology, 25 ((3)): (336-342). [PMID:19749182] |
| 7. Benicio N Frey,Ivan Skelin,Yojiro Sakai,Masami Nishikawa,Mirko Diksic. (2010-07-16) Gender differences in alpha-[(11)C]MTrp brain trapping, an index of serotonin synthesis, in medication-free individuals with major depressive disorder: a positron emission tomography study.. Psychiatry research, 183 ((2)): (157-166). [PMID:20630715] |
| 8. Sujatha Kannan,Fadoua Saadani-Makki,Bindu Balakrishnan,Hui Dai,Pulak K Chakraborty,James Janisse,Otto Muzik,Roberto Romero,Diane C Chugani. (2010-09-10) Decreased cortical serotonin in neonatal rabbits exposed to endotoxin in utero.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 31 ((2)): (738-749). [PMID:20827261] |
| 9. Alexandre Berney,Marco Leyton,Paul Gravel,Igor Sibon,Debbie Sookman,Pedro Rosa Neto,Mirko Diksic,Akio Nakai,Gilbert Pinard,Christo Todorov,Hidehiko Okazawa,Pierre Blier,Thomas Edward Nordahl,Chawki Benkelfat. (2011-03-09) Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder.. Archives of general psychiatry, 68 ((7)): (732-741). [PMID:21383250] |
| 10. Harry T Chugani,Ajay Kumar,William Kupsky,Eishi Asano,Sandeep Sood,Csaba Juhász. (2011-05-17) Clinical and histopathologic correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy.. Epilepsia, 52 ((9)): (1692-1698). [PMID:21569023] |
| 11. Diane C Chugani. (2011-10-19) α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.. Biomarkers in medicine, 5 ((5)): (567-575). [PMID:22003905] |
| 12. Ajay Kumar,Eishi Asano,Harry T Chugani. (2011-10-19) α-[¹¹C]-methyl-L-tryptophan PET for tracer localization of epileptogenic brain regions: clinical studies.. Biomarkers in medicine, 5 ((5)): (577-584). [PMID:22003906] |
| 13. Mario L Muscedere,Natalie Johnson,Brendan C Gillis,J Frances Kamhi,James F A Traniello. (2011-12-03) Serotonin modulates worker responsiveness to trail pheromone in the ant Pheidole dentata.. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 198 ((3)): (219-227). [PMID:22134381] |
| 14. Csaba Juhász,Zeina Nahleh,Ian Zitron,Diane C Chugani,Majid Z Janabi,Sudeshna Bandyopadhyay,Rouba Ali-Fehmi,Thomas J Mangner,Pulak K Chakraborty,Sandeep Mittal,Otto Muzik. (2012-03-27) Tryptophan metabolism in breast cancers: molecular imaging and immunohistochemistry studies.. Nuclear medicine and biology, 39 ((7)): (926-932). [PMID:22444239] |
| 15. Csaba Juhász,Diane C Chugani,Geoffrey R Barger,William J Kupsky,Pulak K Chakraborty,Otto Muzik,Sandeep Mittal. (2012-08-15) Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity.. Clinical nuclear medicine, 37 ((9)): (838-842). [PMID:22889771] |
| 16. Linda Booij,Jean-Paul Soucy,Simon N Young,Martine Regoli,Paul Gravel,Mirko Diksic,Marco Leyton,Robert O Pihl,Chawki Benkelfat. (2014-07-22) Brain serotonin synthesis in MDMA (ecstasy) polydrug users: an alpha-[(11) C]methyl-l-tryptophan study.. Journal of neurochemistry, 131 ((5)): (634-644). [PMID:25041501] |
| 17. Daniel B Schwab,Keeley D Newsom,Armin P Moczek. (2020-09-23) Serotonin signaling suppresses the nutrition-responsive induction of an alternate male morph in horn polyphenic beetles.. Journal of experimental zoology. Part A, Ecological and integrative physiology, 333 ((9)): (660-669). [PMID:32959988] |
| 18. Deanna N Edwards,Verra M Ngwa,Ariel L Raybuck,Shan Wang,Yoonha Hwang,Laura C Kim,Sung Hoon Cho,Yeeun Paik,Qingfei Wang,Siyuan Zhang,H Charles Manning,Jeffrey C Rathmell,Rebecca S Cook,Mark R Boothby,Jin Chen. (2020-12-16) Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer.. The Journal of clinical investigation, 131 ((4)): [PMID:33320840] |
| 19. Alexandre Berney,Masami Nishikawa,Chawki Benkelfat,Guy Debonnel,Gabriella Gobbi,Mirko Diksic. (2007-10-12) An index of 5-HT synthesis changes during early antidepressant treatment: alpha-[11C]methyl-L-tryptophan PET study.. Neurochemistry international, 52 ((4-5)): (701-708). [PMID:17928105] |
| 20. Jun Natsume,Neda Bernasconi,Yahya Aghakhani,Yoshitaka Kumakura,Masami Nishikawa,Marco Fedi,Lahbib Soualmi,François Dubeau,Frederick Andermann,Andrea Bernasconi,Mirko Diksic. (2008-03-28) Alpha-[11C]methyl-L-tryptophan uptake in patients with periventricular nodular heterotopia and epilepsy.. Epilepsia, 49 ((5)): (826-831). [PMID:18363710] |
| 21. Benicio N Frey,Pedro Rosa-Neto,Stuart Lubarsky,Mirko Diksic. (2008-06-28) Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study.. NeuroImage, 42 ((2)): (850-857). [PMID:18583156] |
| 22. Kazuya Kanemaru,Shu Hasegawa,Kyoko Nishi,Mirko Diksic. (2008-08-05) Acute citalopram has different effects on regional 5-HT synthesis in FSL, FRL, and SDP rats: an autoradiographic evaluation.. Brain research bulletin, 77 ((4)): (214-220). [PMID:18674602] |
| 23. Hiroyuki Wakamoto,Diane C Chugani,Csaba Juhász,Otto Muzik,William J Kupsky,Harry T Chugani. (2008-08-30) Alpha-methyl-l-tryptophan positron emission tomography in epilepsy with cortical developmental malformations.. Pediatric neurology, 39 ((3)): (181-188). [PMID:18725063] |
| 24. Kazuya Kanemaru,Kyoko Nishi,Mirko Diksic. (2009-05-26) AGN-2979, an inhibitor of tryptophan hydroxylase activation, does not affect serotonin synthesis in Flinders Sensitive Line rats, a rat model of depression, but produces a significant effect in Flinders Resistant Line rats.. Neurochemistry international, 55 ((7)): (529-535). [PMID:19463878] |
| 25. Nela Pivac,Mirko Diksic. (2011-03-19) The lumped constant of α-methyl-l-tryptophan is not influenced by drugs acting through serotonergic system.. Neurochemistry international, 58 ((7)): (826-832). [PMID:21414366] |
| 26. Bálint Alkonyi,Sandeep Mittal,Ian Zitron,Diane C Chugani,William J Kupsky,Otto Muzik,Harry T Chugani,Sandeep Sood,Csaba Juhász. (2011-11-04) Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors.. Journal of neuro-oncology, 107 ((2)): (365-372). [PMID:22048879] |
| 27. Linda Booij,Chawki Benkelfat,Marco Leyton,Frank Vitaro,Paul Gravel,Mélissa L Lévesque,Louise Arseneault,Mirko Diksic,Richard E Tremblay. (2012-01-20) Perinatal effects on in vivo measures of human brain serotonin synthesis in adulthood: a 27-year longitudinal study.. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 22 ((6)): (419-423). [PMID:22257439] |
| 28. Bálint Alkonyi,Geoffrey R Barger,Sandeep Mittal,Otto Muzik,Diane C Chugani,Gautam Bahl,Natasha L Robinette,William J Kupsky,Pulak K Chakraborty,Csaba Juhász. (2012-06-02) Accurate differentiation of recurrent gliomas from radiation injury by kinetic analysis of α-11C-methyl-L-tryptophan PET.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53 ((7)): (1058-1064). [PMID:22653792] |
| 29. Ivan Skelin,Maraki Fikre-Merid,Mirko Diksic. (2012-10-23) Both acute and subchronic treatments with pindolol, a 5-HT(1A) and β₁ and β₂ adrenoceptor antagonist, elevate regional serotonin synthesis in the rat brain: an autoradiographic study.. Neurochemistry international, 61 ((8)): (1417-1423). [PMID:23084984] |
| 30. Paul Cumming. (2014-08-27) Measuring effects of MDMA (ecstasy) abuse on the rate of cerebral serotonin synthesis.. Journal of neurochemistry, 131 ((5)): (541-545). [PMID:25156194] |
首页
400-620-6333
F2305625