| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M475321-100g |
100g |
期货  |
|
| 英文别名 | AKOS016352717 | DTXCID8020547 | FT-0633931 | Hemoklot | Sepisol | 2-Methyl-1,4-naphthochinon-natrium-bisulfit trihydrat | Menadione bisulfite sodium | Menadione sodium bisulfite [INN] | SHB 264AB | 1,2,3,4-Tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfon |
|---|---|
| 规格或纯度 | BioReagent, 用于细胞培养, ≥95%(TLC) |
| 英文名称 | Menadione sodium bisulfite |
| 储存温度 | -20°C储存 |
| 运输条件 | 超低温冰袋运输 |
| 备注 | 水溶性维生素 K3。 |
| 产品介绍 |
应用 用在细胞培养中诱导氧化应激，用于机理研究。 Description Use in cell culture to induce oxidative stress for mechanistic studies. |
| 纯度 | ≥95%(TLC) |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | sodium;2-methyl-1,4-dioxo-3H-naphthalene-2-sulfonate |
| INCHI | 1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1 |
| InChi Key | XDPFHGWVCTXHDX-UHFFFAOYSA-M |
| Smiles | CC1(CC(=O)C2=CC=CC=C2C1=O)S(=O)(=O)[O-].[Na+] |
| Isomeric SMILES | CC1(CC(=O)C2=CC=CC=C2C1=O)S(=O)(=O)[O-].[Na+] |
| 分子量 | 276.24 |
| Reaxy-Rn | 3922400 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3922400&ln= |
| 溶解性 | 水：可溶50mg/mL，清澈，无色至淡黄色 |
|---|---|
| 熔点 | 121-124°C |
| 分子量 | 276.240 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 5 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 276.007 Da |
| 单同位素质量Monoisotopic Mass | 276.007 Da |
| 拓扑极表面积Topological Polar Surface Area | 99.700 Ų |
| 重原子数Heavy Atom Count | 18 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 466.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| 象形图 | GHS07, GHS09 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H372: 通过长时间或反复暴露对器官造成损害 H410: 对水生生物有剧毒并具有长期持续影响 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P391: 收集溢出物 P302+P352: 如皮肤沾染：用水充分清洗。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 |
| 1. Irina Baran,Constanta Ganea,Agata Scordino,Francesco Musumeci,Vincenza Barresi,Salvatore Tudisco,Simona Privitera,Rosaria Grasso,Daniele F Condorelli,Ioan Ursu,Virgil Baran,Eva Katona,Maria-Magdalena Mocanu,Marisa Gulino,Raluca Ungureanu,Mihaela Surcel,Cornel Ursaciuc. (2010-08-11) Effects of menadione, hydrogen peroxide, and quercetin on apoptosis and delayed luminescence of human leukemia Jurkat T-cells.. Cell biochemistry and biophysics, 58 ((3)): (169-179). [PMID:20697976] |
| 2. Laetitia G Garcia,Sandrine Lemaire,Barbara C Kahl,Karsten Becker,Richard A Proctor,Paul M Tulkens,Françoise Van Bambeke. (2012-09-25) Intracellular forms of menadione-dependent small-colony variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to β-lactams in a THP-1 cell model due to cooperation between vacuolar acidic pH and oxidant species.. The Journal of antimicrobial chemotherapy, 67 ((12)): (2873-2881). [PMID:23002174] |
| 3. Fernanda Luna da Silva,Eduardo Coelho Cerqueira,Mônica Santos de Freitas,Daniela Leão Gonçalves,Lilian Terezinha Costa,Cristian Follmer. (2012-10-16) Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein.. Neurochemistry international, 62 ((1)): (103-112). [PMID:23064431] |
| 4. Catherine L Bladen,David J Kozlowski,William S Dynan. (2012-10-25) Effects of low-dose ionizing radiation and menadione, an inducer of oxidative stress, alone and in combination in a vertebrate embryo model.. Radiation research, 178 ((5)): (499-503). [PMID:23092554] |
| 5. Chunyan Yu,Xiaowei Huang,Ye Xu,Hongyan Li,Jing Su,Jiateng Zhong,Jinsong Kang,Yuhe Liu,Liankun Sun. (2012-11-06) Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in Hela cells.. Anatomical record (Hoboken, N.J. : 2007), 296 ((1)): (31-39). [PMID:23125185] |
| 6. James L Kalabus,Qiuying Cheng,Javier G Blanco. (2012-11-08) MicroRNAs differentially regulate carbonyl reductase 1 (CBR1) gene expression dependent on the allele status of the common polymorphic variant rs9024.. PloS one, 7 ((11)): (e48622-e48622). [PMID:23133646] |
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| 8. Tereza Hartmanová,Vojtěch Tambor,Juraj Lenčo,Claudia A Staab-Weijnitz,Edmund Maser,Vladimír Wsól. (2013-01-09) S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity.. Chemico-biological interactions, 202 ((1-3)): (136-145). [PMID:23295225] |
| 9. Guilherme Maranhão Chaves,Walicyranison Plinio da Silva. (2013-01-09) Superoxide dismutases and glutaredoxins have a distinct role in the response of Candida albicans to oxidative stress generated by the chemical compounds menadione and diamide.. Memorias do Instituto Oswaldo Cruz, 107 ((8)): (998-1005). [PMID:23295749] |
| 10. Golnar Karimian,Manon Buist-Homan,Bojana Mikus,Robert H Henning,Klaas Nico Faber,Han Moshage. (2013-01-10) Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis.. PloS one, 7 ((12)): (e52647-e52647). [PMID:23300732] |
| 11. R J Aitken,T B Smith,T Lord,L Kuczera,A J Koppers,N Naumovski,H Connaughton,M A Baker,G N De Iuliis. (2013-01-15) On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid.. Andrology, 1 ((2)): (192-205). [PMID:23316012] |
| 12. Kaja Kasemets,Sandra Suppi,Kai Künnis-Beres,Anne Kahru. (2013-01-24) Toxicity of CuO nanoparticles to yeast Saccharomyces cerevisiae BY4741 wild-type and its nine isogenic single-gene deletion mutants.. Chemical research in toxicology, 26 ((3)): (356-367). [PMID:23339633] |
| 13. Natalie Gleyzer,Richard C Scarpulla. (2013-02-01) Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence.. The Journal of biological chemistry, 288 ((12)): (8004-8015). [PMID:23364789] |
| 14. Abul Hasan Sardar,Sudeep Kumar,Ashish Kumar,Bidyut Purkait,Sushmita Das,Abhik Sen,Manish Kumar,Kislay Kumar Sinha,Dharmendra Singh,Asif Equbal,Vahab Ali,Pradeep Das. (2013-02-05) Proteome changes associated with Leishmania donovani promastigote adaptation to oxidative and nitrosative stresses.. Journal of proteomics, 81 (185-199). [PMID:23376486] |
| 15. (2013-02-06) A non-classical LysR-type transcriptional regulator PA2206 is required for an effective oxidative stress response in Pseudomonas aeruginosa.. PloS one, 8 ((1)): (e54479-e54479). [PMID:23382903] |
| 16. Shiro Yamashoji,Naoko Yoshikawa,Masayuki Kirihara,Toshihiro Tsuneyoshi. (2013-03-19) Screening test for rapid food safety evaluation by menadione-catalysed chemiluminescent assay.. Food chemistry, 138 ((4)): (2146-2151). [PMID:23497869] |
| 17. Rachel P Wilkie-Grantham,Shu-Ichi Matsuzawa,John C Reed. (2013-03-23) Novel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP protein.. The Journal of biological chemistry, 288 ((18)): (12777-12790). [PMID:23519470] |
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| 19. Yu-Ran Na,Ki-Cheol Han,Hyunsung Park,Eun Gyeong Yang. (2013-04-27) Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300.. Biochemical and biophysical research communications, 434 ((4)): (879-884). [PMID:23618863] |
| 20. Ghada S Hassan. (2013-05-15) Menadione.. Profiles of drug substances, excipients, and related methodology, 38 (227-313). [PMID:23668406] |
| 21. Sanjeev Kumar,Satyendra Gautam,Arun Sharma. (2013-05-22) Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones.. Mutation research, 755 ((1)): (30-41). [PMID:23688616] |
| 22. Yu Jiang,Jingbo Yang,Chunhui Yang,Fanmin Meng,Yongfeng Zhou,Bo Yu,Muhammad Khan,Hong Yang. (2013-07-24) Vitamin K4 induces tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway.. Die Pharmazie, 68 ((6)): (442-448). [PMID:23875252] |
| 23. Yoshihisa Hirota,Naoko Tsugawa,Kimie Nakagawa,Yoshitomo Suhara,Kiyoshi Tanaka,Yuri Uchino,Atsuko Takeuchi,Natsumi Sawada,Maya Kamao,Akimori Wada,Takashi Okitsu,Toshio Okano. (2013-10-03) Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats.. The Journal of biological chemistry, 288 ((46)): (33071-33080). [PMID:24085302] |
| 24. Melissa A Dean,Randall J Olsen,S Wesley Long,Adriana E Rosato,James M Musser. (2014-01-24) Identification of point mutations in clinical Staphylococcus aureus strains that produce small-colony variants auxotrophic for menadione.. Infection and immunity, 82 ((4)): (1600-1605). [PMID:24452687] |
| 25. Irina Baran,Diana Ionescu,Alexandru Filippi,Maria Magdalena Mocanu,Adrian Iftime,Ramona Babes,Ioana Teodora Tofolean,Ruxandra Irimia,Alexandru Goicea,Valentin Popescu,Alexandru Dimancea,Andrei Neagu,Constanta Ganea. (2014-05-28) Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells.. Leukemia research, 38 ((7)): (836-849). [PMID:24862793] |
| 26. Dmytro V Gospodaryov,Oleh V Lushchak,Bohdana M Rovenko,Natalia V Perkhulyn,Mike Gerards,Tea Tuomela,Howard T Jacobs. (2014-08-16) Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila.. Biochimica et biophysica acta, 1837 ((11)): (1861-1869). [PMID:25124484] |
| 27. Maya Berg,Raquel García-Hernández,Bart Cuypers,Manu Vanaerschot,José I Manzano,José A Poveda,José A Ferragut,Santiago Castanys,Jean-Claude Dujardin,Francisco Gamarro. (2015-02-04) Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.. Antimicrobial agents and chemotherapy, 59 ((4)): (2242-2255). [PMID:25645828] |
| 28. James A Bynum,Ashish Rastogi,Salomon A Stavchansky,Phillip D Bowman. (2015-05-01) Cytoprotection of human endothelial cells from oxidant stress with CDDO derivatives: network analysis of genes responsible for cytoprotection.. Pharmacology, 95 ((3-4)): (181-192). [PMID:25926128] |
| 29. Muhammad Khurram,Linda A Lawton,Christine Edwards,Marcello Iriti,Abdul Hameed,Murad A Khan,Farman A Khan,Shafiq Ur Rahman. (2015-09-08) Rapid Bioassay-Guided Isolation of Antibacterial Clerodane Type Diterpenoid from Dodonaea viscosa (L.) Jaeq.. International journal of molecular sciences, 16 ((9)): (20290-20307). [PMID:26343638] |
| 30. Pranita K Kabadi,Marguerite M Vantangoli,April L Rodd,Elizabeth Leary,Samantha J Madnick,Jeffrey R Morgan,Agnes Kane,Kim Boekelheide. (2015-11-12) Into the depths: Techniques for in vitro three-dimensional microtissue visualization.. BioTechniques, 59 ((5)): (279-286). [PMID:26554505] |
| 31. Valentina Sica,Jose Manuel Bravo-San Pedro,Valentina Izzo,Jonathan Pol,Sandra Pierredon,David Enot,Sylvère Durand,Noélie Bossut,Alexis Chery,Sylvie Souquere,Gerard Pierron,Evangelia Vartholomaiou,Naoufal Zamzami,Thierry Soussi,Allan Sauvat,Laura Mondragón,Oliver Kepp,Lorenzo Galluzzi,Jean-Claude Martinou,Holger Hess-Stumpp,Karl Ziegelbauer,Guido Kroemer,Maria Chiara Maiuri. (2019-04-18) Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.. Cell reports, 27 ((3)): (820-834). [PMID:30995479] |
| 32. Takashi Miyai,Shivakumar Vasanth,Geetha Melangath,Neha Deshpande,Varun Kumar,Anne-Sophie Benischke,Yuming Chen,Marianne O Price,Francis W Price,Ula V Jurkunas. (2019-07-31) Activation of PINK1-Parkin-Mediated Mitophagy Degrades Mitochondrial Quality Control Proteins in Fuchs Endothelial Corneal Dystrophy.. The American journal of pathology, 189 ((10)): (2061-2076). [PMID:31361992] |
| 33. Joshua T Kowalczyk,Xiaolin Wan,Edjay R Hernandez,Ruibai Luo,Gaelyn C Lyons,Kelli M Wilson,Devorah C Gallardo,Kristine A Isanogle,Christina M Robinson,Arnulfo Mendoza,Christine M Heske,Jinqui-Qiu Chen,Xiaoling Luo,Alexander E Kelly,Simone Difilippantinio,Robert W Robey,Craig J Thomas,Dan L Sackett,Deborah K Morrison,Paul A Randazzo,Lisa M Miller Jenkins,Marielle E Yohe. (2020-11-08) Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma.. Molecular cancer therapeutics, 20 ((2)): (307-319). [PMID:33158997] |
| 34. Joonhoon Kim,Samuel T Coradetti,Young-Mo Kim,Yuqian Gao,Junko Yaegashi,Jeremy D Zucker,Nathalie Munoz,Erika M Zink,Kristin E Burnum-Johnson,Scott E Baker,Blake A Simmons,Jeffrey M Skerker,John M Gladden,Jon K Magnuson. (2021-02-16) Multi-Omics Driven Metabolic Network Reconstruction and Analysis of Lignocellulosic Carbon Utilization in Rhodosporidium toruloides.. Frontiers in bioengineering and biotechnology, 8 (612832-612832). [PMID:33585414] |
| 35. Kenneth W Olsen,Vladimir Bantseev,Vivan Choh. (2011-02-02) Menadione degrades the optical quality and mitochondrial integrity of bovine crystalline lenses.. Molecular vision, 17 (270-278). [PMID:21283527] |
| 36. Tomokazu Souma,Michiaki Abe,Takashi Moriguchi,Jun Takai,Noriko Yanagisawa-Miyazawa,Eisuke Shibata,Yasutoshi Akiyama,Takafumi Toyohara,Takehiro Suzuki,Masayuki Tanemoto,Takaaki Abe,Hiroshi Sato,Masayuki Yamamoto,Sadayoshi Ito. (2011-03-05) Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells.. Journal of the American Society of Nephrology : JASN, 22 ((4)): (635-648). [PMID:21372211] |
| 37. Marco Tomasetti,Linda Nocchi,Jiri Neuzil,Jacob Goodwin,Maria Nguyen,Lanfeng Dong,Nicola Manzella,Sara Staffolani,Claudio Milanese,Beatrice Garrone,Renata Alleva,Battista Borghi,Lory Santarelli,Roberto Guerrieri. (2012-12-29) Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death.. PloS one, 7 ((12)): (e52263-e52263). [PMID:23272231] |
| 38. Arto Heiskanen,Vasile Coman,Natalie Kostesha,David Sabourin,Nick Haslett,Keith Baronian,Lo Gorton,Martin Dufva,Jenny Emnéus. (2013-02-02) Bioelectrochemical probing of intracellular redox processes in living yeast cells--application of redox polymer wiring in a microfluidic environment.. Analytical and bioanalytical chemistry, 405 ((11)): (3847-3858). [PMID:23371527] |
| 39. Chun-Ru Yang,Wei-Siang Liao,Ya-Hui Wu,Kaliyappan Murugan,Chinpiao Chen,Jui-I Chao. (2013-10-17) CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction.. Toxicology and applied pharmacology, 273 ((3)): (611-622). [PMID:24128853] |
| 40. Pedro Miramón,Christine Dunker,Lydia Kasper,Ilse D Jacobsen,Dagmar Barz,Oliver Kurzai,Bernhard Hube. (2014-03-15) A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans.. Medical mycology, 52 ((3)): (223-239). [PMID:24625675] |
| 41. Y Sanada,S Asai,A Ikemoto,T Moriwaki,N Nakamura,M Miyaji,Q-M Zhang-Akiyama. (2014-05-29) Oxidation resistance 1 is essential for protection against oxidative stress and participates in the regulation of aging in Caenorhabditis elegans.. Free radical research, 48 ((8)): (919-928). [PMID:24865925] |
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