| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M427157-1ml |
1ml |
期货  |
|
| 英文别名 | meropenem | 96036-03-2 | Merrem | Meropenem anhydrous | Meropenemum | Antibiotic SM 7338 | MERONEM | Merrem I.V. | MEPM | 119478-56-7 | Meropenem [INN] | CHEBI:43968 | SM 7338 | Meropenem, anhydrous | UNII-YOP6PX0BAO | YOP6PX0BAO | SM-7338 | Meropenemum [INN-Latin] | (4r,5s,6s)-3-{[(3s,5s)- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Meropenem |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (4R,5S,6S)-3-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| INCHI | 1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)/t7-,8-,9+,10+,11-,12-/m1/s1 |
| InChi Key | DMJNNHOOLUXYBV-PQTSNVLCSA-N |
| Smiles | CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O |
| Isomeric SMILES | C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1S[C@H]3C[C@H](NC3)C(=O)N(C)C)C(=O)O)[C@@H](C)O |
| 分子量 | 383.47 |
| Reaxy-Rn | 24950258 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24950258&ln= |
| 闪点(℃) | 333.2ºC |
|---|---|
| 沸点 | 627.4ºC |
| 分子量 | 383.500 g/mol |
| XLogP3 | -2.400 |
| 氢键供体数Hydrogen Bond Donor Count | 3 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 5 |
| 精确质量Exact Mass | 383.151 Da |
| 单同位素质量Monoisotopic Mass | 383.151 Da |
| 拓扑极表面积Topological Polar Surface Area | 135.000 Ų |
| 重原子数Heavy Atom Count | 26 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 679.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 6 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07, GHS08 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H315: 引起皮肤刺激 H317: 可能引起皮肤过敏反应 H319: 引起严重眼睛刺激 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H335: 可能引起呼吸道刺激 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P272: 被污染的工作服不允许离开工作场所 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P284: 如果通风不良，请佩戴呼吸防护装置。 P321: 特殊处理（请参阅此标签上的...）。 P302+P352: 如皮肤沾染：用水充分清洗。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P405: 密闭存放 P403+P233: 存放在通风良好的地方。保持容器密闭。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 P342+P316: 如果出现呼吸道症状：立即寻求急救。 |
| 1. Jingzhi Yang, Yami Ran, Shaopeng Liu, Chenhao Ren, Yuntian Lou, Pengfei Ju, Guoliang Li, Xiaogang Li, Dawei Zhang. (2023) Synergistic D-Amino Acids Based Antimicrobial Cocktails Formulated via High-Throughput Screening and Machine Learning. Advanced Science, 11 (9): (2307173). [PMID:38126652] [10.1002/advs.202307173] |
| 2. Yexuan Mao, Yichao Fan, Ran Yang, Youyi Wang, Qingyue Li, Meng Dang, Xianqing Huang, Lianjun Song, Pingan Zhang, Miao Song, Liang Liu, Linli Wang, Shun Yu, Qiuyan Zhao, Xiya Zhang. (2023) A highly sensitive electrochemical sensor derived from peptide amphiphilic inspired self-assembled, ordered gold nanoparticles for determination of 22 β-lactams. ELECTROCHIMICA ACTA, 461 (142669). [10.1016/j.electacta.2023.142669] |
| 3. Xuan Ma, Yue Wang, Wenting Wang, Jake Heinlein, Lisa D. Pfefferle, Xuemeng Tian. (2023) Strategic preparation of porous magnetic molecularly imprinted polymers via a simple and green method for high-performance adsorption and removal of meropenem. TALANTA, 258 (124419). [PMID:36893497] [10.1016/j.talanta.2023.124419] |
| 4. Yan Wang, Lanyu Liu, Qiping Wu, Qiufen Yin, Feifan Xie. (2022) Defining Exposure Predictors of Meropenem That Are Associated with Improved Survival for Severe Bacterial Infection: A Preclinical PK/PD Study in Sepsis Rat Model. Antibiotics-Basel, 11 (11): (1660). [PMID:36421304] [10.3390/antibiotics11111660] |
| 5. Suo Decheng, Fan Xia, Xiao Zhiming, Liyang, Wang Peilong. (2022) Simultaneous determination of eight carbapenems in milk by modified QuEChERS and ultra high performance liquid chromatography coupled with high-field quadrupole-orbitrap high-resolution mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1670 (462979). [PMID:35349916] [10.1016/j.chroma.2022.462979] |
| 6. Lan Sugui, Li Zhirong, Su Aiqiu, Peng Yanhong, Liao Yanke, Liu Xuemei, Tan Qiang. (2021) Study on the mechanisms of the cross-resistance to TET, PIP, and GEN in Staphylococcus aureus mediated by the Rhizoma Coptidis extracts. JOURNAL OF ANTIBIOTICS, 74 (5): (330-336). [PMID:33500562] [10.1038/s41429-021-00407-4] |
| 7. Zhimin Lu, Xiaonan Wang, Licai Ma, Leina Dou, Xiangjun Zhao, Jin Tao, Yang Wang, Shaolin Wang, Dejun Liu, Yingbo Shen, Xuezhi Yu, Wenbo Yu, Liangxi Jia, Zhanhui Wang, Jianzhong Shen, Kai Wen. (2024) Carba PBP: a novel penicillin-binding protein-based lateral flow assay for rapid phenotypic detection of carbapenemase-producing Enterobacterales. JOURNAL OF CLINICAL MICROBIOLOGY, 62 (2): (2024 Jan;62(2)). [PMID:38284761] [10.1128/jcm.00120-23] |
| 8. Jianxu Bao, Shifan Chen, Xianda Liu, Ziyue Ling, Chunji Jiang, Zhaoxi Han, Wenjie Wang, Ran Wei, Changsheng Zhao, Weifeng Zhao. (2025) Electrospun groove shaped fibers with excellent hemocompatibility and highly selective capture of live bacteria from blood. CHEMICAL ENGINEERING JOURNAL, 509 (161250). [10.1016/j.cej.2025.161250] |
| 9. Cheng Wenhui, Zhang Yuejuan, Chen Cheng, Gao Lei, Lv Yuwei, Yu Dian, Chen Bin, Wan Yi. (2024) Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48. MEDICINAL CHEMISTRY RESEARCH, (1-10). [10.1007/s00044-023-03185-w] |
| 10. Xiaonan Zhang, Yan Wang, Sanwang Li, Feifan Xie, Hanxi Yi. (2024) Simulated drug disposition in critically ill patients to evaluate effective PK/PD targets for combating Pseudomonas aeruginosa resistance to meropenem. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 68 (3): (2024 Feb;68(3)). [PMID:38319075] [10.1128/aac.01541-23] |
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