| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M424874-1ml |
1ml |
现货  |
|
| 别名 | 十六烷基磷酰胆碱 |
|---|---|
| 英文别名 | Miltefosine | 58066-85-6 | Hexadecylphosphocholine | Miltex | Impavido | HDPC | Hexadecylphosphorylcholine | Miltefosina | Miltefosinum | n-Hexadecylphosphorylcholine | Miltefos | 1-Hexadecylphosphorylcholine | hexadecyl 2-(trimethylazaniumyl)ethyl phosphate | n-hexadecylphosphoch |
| 规格或纯度 | Moligand™, 10mM in Water |
| 英文名称 | Miltefosine |
| 生化机理 | 烷基磷酸胆碱PI 3-激酶和Akt抑制剂。阻断IgE受体依赖性肥大细胞活化。在体内口服具有抗寄生虫作用（IC 50 = 260 nM，利什曼原虫），并具有抗肿瘤作用。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | AKT 血清/苏氨酸激酶 1 抑制剂 |
| ALogP | 6.7 |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | hexadecyl 2-(trimethylazaniumyl)ethyl phosphate |
| INCHI | 1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3 |
| InChi Key | PQLXHQMOHUQAKB-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C |
| Isomeric SMILES | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C |
| 分子量 | 407.57 |
| Reaxy-Rn | 3690495 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3690495&ln= |
| 敏感性 | 对热敏感 |
|---|---|
| 熔点 | 216 °C(dec.) |
| 分子量 | 407.600 g/mol |
| XLogP3 | 6.700 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 20 |
| 精确质量Exact Mass | 407.316 Da |
| 单同位素质量Monoisotopic Mass | 407.316 Da |
| 拓扑极表面积Topological Polar Surface Area | 58.600 Ų |
| 重原子数Heavy Atom Count | 27 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 363.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS06 |
|---|---|
| 信号词 | 危险 |
| 危险声明 |
H301: 吞咽会中毒 H361: 怀疑破坏生育力或未出生的孩子 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P330: 漱口 P301+P310: 如误吞咽：立即呼叫急救中心/医生。 P308+P313: 如接触到或有疑虑：求医/就诊。 |
| WGK Germany | 3 |
| RTECS | KH2890000 |
| Merck Index | 6198 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
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| 2. Zheng Pei-Yao, Zhang Ping, Sun Zhi-Wei, Zhu Chen-Hui, An Quan-Fu. (2018) Nanostructured polyelectrolyte-surfactant complex pervaporation membranes for ethanol recovery: the relationship between the membrane structure and separation performance. CHINESE JOURNAL OF POLYMER SCIENCE, 36 (1): (25-33). [10.1007/s10118-018-2006-1] |
| 3. Qian Zhou, Youxiu Lin, Yuping Lin, Qiaohua Wei, Guonan Chen, Dianping Tang. (2016) Highly sensitive electrochemical sensing platform for lead ion based on synergetic catalysis of DNAzyme and Au–Pd porous bimetallic nanostructures. BIOSENSORS & BIOELECTRONICS, 78 (236). [PMID:26615514] [10.1016/j.bios.2015.11.055] |
| 4. Jie-Ning Zheng, Shan-Shan Li, Fang-Yi Chen, Ning Bao, Ai-Jun Wang, Jian-Rong Chen, Jiu-Ju Feng. (2014) Facile synthesis of platinum–ruthenium nanodendrites supported on reduced graphene oxide with enhanced electrocatalytic properties. JOURNAL OF POWER SOURCES, 266 (259). [10.1016/j.jpowsour.2014.04.128] |
| 5. Lifen Zhang, Yao Yu, Qi Wang, Xi Huang, Zheng Feng, Zhi Li. (2024) Oridonin Loaded Peptide Nanovesicles Alleviate Nonalcoholic Fatty Liver Disease in Mice. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, [PMID:38327230] [10.1080/10837450.2024.2315460] |
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