| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| M424450-1ml |
1ml |
现货  |
|
| 英文别名 | 1H,5H,10H-DIPYRIDO(2,1-F:3',2',1'-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AS,13AR,13BR,13CS)- | alpha-Matrine | N390W430AC | 5-24-02-00301 (Beilstein Handbook Reference) | MATRINE [WHO-DD] | UNII-N390W430AC | a-Matrine | CVE73CZ65H | M2120 | Matriniu |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Matrine |
| 生化机理 | 说明：IC50 值：540 μg/ml（抑制胃癌细胞株 MNK45，MTT）[1]马钱子碱是一种存在于槐属植物中的生物碱。它具有多种药理作用，包括抗癌作用，以及作为卡巴阿片受体和γ-受体激动剂的作用：MTT 试验表明，马钱子碱能以剂量依赖的方式抑制胃癌细胞株 MNK45。抑制 50%所需的浓度（IC50）为 540 μg/ml。这种抗肿瘤功能是通过调节细胞株 MNK45 中 NF-κB、XIAP、CIAP 和 p-ERK 蛋白的表达实现的。麻黄碱能诱导人NSCLC细胞凋亡，抗凋亡因子受到抑制，并依赖于caspase活性。此外，我们还发现，松脂酸能增加 p38 的磷酸化，但不能增加其总蛋白，而用 SB202190 抑制 p38 通路能部分防止松脂酸诱导的细胞凋亡。此外，马钱子碱还能从洋槐中提取活性生物碱。具有多种药理作用，包括抗肿瘤、抗纤维化、抗炎和抗肿瘤活性。通过破坏线粒体膜电位诱导细胞凋亡。抑制 C． |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IIUPAC Name | (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one |
| INCHI | 1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 |
| InChi Key | ZSBXGIUJOOQZMP-JLNYLFASSA-N |
| Smiles | C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1 |
| Isomeric SMILES | C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1 |
| 分子量 | 248.36 |
| Reaxy-Rn | 102206 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=102206&ln= |
| 比旋光度 | 33 ° (C=1, EtOH) |
|---|---|
| 熔点 | 85°C |
| 分子量 | 248.360 g/mol |
| XLogP3 | 1.600 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 0 |
| 精确质量Exact Mass | 248.189 Da |
| 单同位素质量Monoisotopic Mass | 248.189 Da |
| 拓扑极表面积Topological Polar Surface Area | 23.600 Ų |
| 重原子数Heavy Atom Count | 18 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 356.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 4 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | 警告 |
| 危险声明 |
H302: 吞食有害 H319: 引起严重眼睛刺激 |
| 预防措施声明 |
P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P330: 漱口 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| WGK Germany | 3 |
| Merck Index | 5759 |
| 1. Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang. (2023) In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection. JOURNAL OF FISH DISEASES, 46 (9): (977-986). [PMID:37294673] [10.1111/jfd.13818] |
| 2. Mi Wang, Zhenyuan Wang, Jichuan Zhang, Liguo Zhang, Wei Wang, Jingbo Zhan, Ya Liao, Chengyu Wu, Wen Yu, Jiaheng Zhang. (2023) A matrine-based supramolecular ionic salt that enhances the water solubility, transdermal delivery, and bioactivity of salicylic acid. CHEMICAL ENGINEERING JOURNAL, 468 (143480). [10.1016/j.cej.2023.143480] |
| 3. Kai Zhou, Hua Chen, Xiao-yu Wang, Yan-mei Xu, Yu-feng Liao, Yuan-yuan Qin, Xue-wan Ge, Ting-ting Zhang, Zhong-lin Fang, Bei-bei Fu, Qing-Zhong Xiao, Feng-qin Zhu, Si-rui Chen, Xue-sheng Liu, Qi-chao Luo, Shan Gao. (2022) Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury. BIOMEDICINE & PHARMACOTHERAPY, 155 (113792). [PMID:36271569] [10.1016/j.biopha.2022.113792] |
| 4. Jia Liu, Hui Du, Tao Liu, Cheng Chen, Ying Yan, Tianqiang Liu, Lei Liu, Erlong Wang. (2022) Accurate reflection of hepatopancreas antioxidation and detoxification in Procambarus clarkii during virus infection and drug treatment: Reference gene selection, evaluation and expression analysis. AQUACULTURE, 556 (738283). [10.1016/j.aquaculture.2022.738283] |
| 5. Chengfei Song, Jinyu Zhao, Ruirui Zheng, Chi Hao, Xizhong Yan. (2022) Chemical composition and bioactivities of thirteen non-host plant essential oils against Plutella xylostella L. (Lepidoptera: Plutellidae). JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, 25 (101881). [10.1016/j.aspen.2022.101881] |
| 6. Yu Haipeng, Zhu Bolan, Yang Wan, Zhang Qian, Wang Wei, Zhai Weichun, Lu Lixia, Zheng Ying, Dang Zheng, Li Bin, Li Chuyi, Liang Bin, Zhang Jiucong, Yu Xiaohui. (2020) Matrine inhibits proliferation and migration of HepG2 cells by downregulating ERK1/2 signaling pathways. Journal of Cancer Research and Therapeutics, 16 (2): (209). [PMID:32474503] [10.4103/jcrt.JCRT_331_19] |
| 7. Quanliang Li, Shuya Zhang, Mingyu Wang, Shouguang Dong, Yan Wang, Song Liu, Tiancheng Lu, Yuqin Fu, Xiuran Wang, Guihong Chen. (2019) Downregulated miR‑21 mediates matrine‑induced apoptosis via the PTEN/Akt signaling pathway in FTC‑133 human follicular thyroid cancer cells. Oncology Letters, 18 (4): (3553-3560). [PMID:31579406] [10.3892/ol.2019.10693] |
| 8. Zhang Peng, Wang Junqian, Ding Xuanwei, Lin Jun, Jiang Hao, Zhou Hongjun, Lu Yuan. (2019) Exploration of the Tolerance Ability of a Cell-Free Biosynthesis System to Toxic Substances. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 189 (4): (1096-1107). [PMID:31161383] [10.1007/s12010-019-03039-5] |
| 9. Wei Zhou, Yikun Liu, Xiaoyan Liao, Zilin Chen. (2019) Capillary electrophoresis-mass spectrometry using robust poly(ether ether ketone) capillary for tolerance to high content of organic solvents. JOURNAL OF CHROMATOGRAPHY A, 1593 (156). [PMID:30718059] [10.1016/j.chroma.2019.01.070] |
| 10. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, 1568 (123). [PMID:30005943] [10.1016/j.chroma.2018.07.031] |
| 11. Junping Zhang, Yanchun Wang, Wei Zheng. (2017) Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens. MOLECULES, 22 (4): (575). [PMID:28368325] [10.3390/molecules22040575] |
| 12. Yongsheng Yang, Qiumei Dong, Rongheng Li. (2017) Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 39 (2): (307-316). [PMID:28035365] [10.3892/ijmm.2016.2843] |
| 13. Qing Wang, Ling Tong, Lin Yao, Peng Zhang, Li Xu. (2016) Fingerprinting of traditional Chinese medicines on the C18-Diol mixed-mode column in online or offline two-dimensional liquid chromatography on the single column modes. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 125 (205). [PMID:27031576] [10.1016/j.jpba.2016.03.033] |
| 14. Jun Xiang, Yugang Jiang. (2013) Antiepileptic Potential of Matrine via Regulation the Levels of Gamma-Aminobutyric Acid and Glutamic Acid in the Brain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 14 (12): (23751-23761). [PMID:24317434] [10.3390/ijms141223751] |
| 15. Juan Zhang, Zilin Chen. (2013) Determination of Matrine and Oxymatrine in Sophora Flavescens by Nonaqueous Capillary Electrophoresis-Electrospray Ionization-Ion Trap-Mass Spectrometry. ANALYTICAL LETTERS, [10.1080/00032719.2012.726684] |
| 16. Fangyuan Zhao, Le Wang, Yanling Liu, Ge Song, Fei Wang, Baoxian Ye. (2012) Determination of Matrine Using a New Voltammetric Sensor Based on L-Cysteine/Graphene Oxide-Chitosan Composite Film Modified Electrode. ELECTROANALYSIS, 24 (3): (691-698). [10.1002/elan.201100594] |
| 17. Liyun Ma,Si-Min Liu,Lin Yao,Li Xu. (2014-12-22) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica.. Journal of chromatography. A, 1376 (64-73). [PMID:25528071] |
| 18. Shaoqi Qu, Shuo Yang, Qingjun Xu, Mengying Zhang, Feng Gao, Yongning Wu, Lin Li. (2024) A Milk Extracellular Vesicle-Based Nanoplatform Enhances Combination Therapy Against Multidrug-Resistant Bacterial Infections. Advanced Science, (2406496). [PMID:39721033] [10.1002/advs.202406496] |
| 19. Dimei Hu, Lulu Yu, Zijian Wei, Lingpeng Zhan, Peiqi Luo. (2024) B4C-Assisted Paper Spray Ionization Mass Spectrometry. JOURNAL OF MASS SPECTROMETRY, 59 (11): (e5098). [PMID:39397358] [10.1002/jms.5098] |
| 20. Kaigang An, Xin Li, Jia Chen, Shuang Zhang, Jing Xiao, Qing Wang, Hongdeng Qiu. (2024) Deep eutectic solvent-assisted synthesis of La–Ce hybrid nanorods for the colorimetric determination of tetracycline in foods. Analytical Methods, 16 (22): (3551-3561). [PMID:38780040] [10.1039/D4AY00412D] |
| 21. Yi Wang, Wanxin Liu, Ziwei Chen, Kaixin Zheng, Xianliang Yi, Jiao Wang, Xiaochen Chen, Xianhua Liu. (2025) Distinct responses of Caenorhabditis elegans to polyethylene microplastics and plant secondary metabolites. ENVIRONMENTAL POLLUTION, 372 (126051). [PMID:40086784] [10.1016/j.envpol.2025.126051] |
| 22. Lingxiao He, Ning Ma, Zhengyun Liang, Sidan Zhao, Jiaming Yan, Hanchen Lin, Chaoqun You, Lingchao Cai, Fei Wang. (2024) Fabrication of sulfonated cellulose nanocrystals/sodium alginate beads for adsorbents of matrine. MICROCHEMICAL JOURNAL, 203 (110766). [10.1016/j.microc.2024.110766] |
| 23. Min-Hui Zhang, Shu-Yu Bao, Ke Zheng, Hai-Li Sun, Ye-Jia Li, Xi-Can Li, Quan-Zhou Wu, Jian-Feng He. (2025) Highly specific molecularly imprinted microspheres prepared based on dopamine/polyethyleneimine coating and carboxyl-functionalized POSS supports for selective separation of cepharanthine. SEPARATION AND PURIFICATION TECHNOLOGY, 364 (132375). [10.1016/j.seppur.2025.132375] |
| 24. Aimin Qiao, Meiqing Pan, Yue Zeng, Ying Gong, Yunfeng Zhang, Xiucai Lan, Lei Tang, Weizhang Jia. (2025) Matrine Inhibits High-Glucose-Diet-Induced Fat Accumulation and Aβ-Mediated Lipid Metabolic Disorder via AAK-2/NHR-49 Pathway in Caenorhabditis elegans. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 26 (7): (3048). [10.3390/ijms26073048] |
| 25. Lanfei Wang, Nianfeng Qiu, Suyuan Tong, Yan Yu, Shuhua Xi, Fei Wang. (2024) Matrine Suppresses Arsenic-Induced Malignant Transformation of SV-HUC-1 Cells via NOX2. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (16): (8878). [PMID:39201564] [10.3390/ijms25168878] |
| 26. Yanhui Ge, Liuyang Ding, Yubo Liu, Xiong Li. (2024) Synthesis, characterization and evaluation of a pH-responsive molecular imprinted polymer for Matrine as an intelligent drug delivery system. E-POLYMERS, 24 (1): [10.1515/epoly-2023-0184] |
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